Exam 5: The Integumentary System Unit Ii: Principles of Support and Movement

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John has lost approximately 27% of his skin's surface area (according to the Rule of Nines),which leads to severe systemic effects.The epidermis,dermis,subcutaneous layer and associated structures have been destroyed.Sensory function is lost.Loss of epidermis (and so,lost keratin and Langerhans cells)makes John susceptible to microbial invasion.Loss of keratinized structures and lamellar granules allows for extreme loss of water,plasma,and plasma proteins,which causes shock;leading to dehydration,reduced blood volume and circulation,decreased urine output and diminished immune responses.
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