Exam 12: Naturally Occurring and Synthetic Opiates and Their Antagonists

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What are three features of narcotics that distinguish them pharmacologically from other drugs with sedative-hypnotic properties, such as barbiturates and benzodiazepines?

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Narcotics (opiates) bind stereospecifically to endorphin/enkephalin receptors, produce profound analgesia without inducing sleep, and their effects are blocked with naloxone or naltrexone. Barbiturates and benzodiazepines induce actions via non-opioid receptors, and their effects are not blocked with naloxone or naltrexone. Barbiturates only produce significant analgesia with anesthetic-sleep, and benzodiazepines are not analgesics, nor can they produce a state of surgical anesthesia when used alone

Which of these drugs would successfully reverse the effects of narcotics in an acute overdose?

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C

Opioid antagonists have been found to be useful in

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D

Briefly describe the system the British presently use in dealing with heroin addiction.

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The Harrison Act of 1914 made it illegal in the U.S.to

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Opioid antagonists have been found to be useful in

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Which of the following would narcotic addicts being treated for their addiction most likely to continue taking on a maintenance basis?

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With chronic exposure, which of these opioids will result in tolerance to many of its effects?

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What factors account for the majority of deaths associated with heroin use?

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What are three pharmacological characteristics that distinguish morphine from cocaine?

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Compare and contrast the relative efficacy of methadone (Dolophine) and naltrexone (ReVia) in the treatment of heroin addiction.

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Buprenorphine (Suboxone, Subutex)

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The abstinence syndrome associated with opiate withdrawal

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Naltrexone (ReVia) is not likely going to be a very common treatment for heroin addiction because

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The abstinence syndrome associated with withdrawal from chronic heroin use is generally ________________________ with methadone withdrawal.

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The FDA has recently approved the use of Suboxone, which is a combination of buprenorphine and naloxone, in the treatment of opiate addiction.The addition of naloxone to buprenorphine

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Most of the deaths attributed to narcotic use are the result of

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The use of heroin under sterile conditions has been associated with lesions and/or cell death in the

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Which of the following narcotics has the longest duration of effect?

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Which of the following is NOT a feature of the way heroin addiction is dealt with in the United Kingdom?

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