Question 1

The euphorigenic properties of opiates like morphine are believed to be due to their activity at which type of receptor?

Accepted Answer

A) mu 
B) kappa 
C) sigma 
D) 5-HT 
A) mu 
B) kappa 
C) sigma 
D) 5-HT

Question 2

A key property of opioid drugs which underlies their addiction liability is their ability to indirectly activate _________________________ neurons projecting to the nucleus accumbens.

Accepted Answer

A) cholinergic 
B) serotonergic 
C) noradrenergic 
D) dopaminergic 
A) cholinergic 
B) serotonergic 
C) noradrenergic 
D) dopaminergic

Question 3

In the treatment of heroin addiction, the narcotic agonist LAAM (Orlamm) and the mixed agonist-antagonist buprenorphine (Suboxone, Subutex) have advantages over methadone in terms of

Accepted Answer

A) suppressing the addicts' use of heroin 
B) effectiveness in withdrawal detoxification 
C) blocking the effects of heroin 
D) their considerably longer durations of action 
A) suppressing the addicts' use of heroin 
B) effectiveness in withdrawal detoxification 
C) blocking the effects of heroin 
D) their considerably longer durations of action

Question 4

Which of these is the most potent and short-acting narcotic?

Accepted Answer

A) morphine 
B) heroin 
C) fentanyl 
D) methadone 
A) morphine 
B) heroin 
C) fentanyl 
D) methadone

Question 5

Which of the following has NOT been associated with the legal restrictions resulting from the Harrison Narcotic Act of 1914?

Accepted Answer

A) increased use of intravenous narcotic use 
B) decreased narcotic related crime 
C) increased price of illicit narcotics 
D) increased toxicity and lethality associated with using illicit narcotics 
A) increased use of intravenous narcotic use 
B) decreased narcotic related crime 
C) increased price of illicit narcotics 
D) increased toxicity and lethality associated with using illicit narcotics

Question 6

Ultrarapid opioid detoxification utilizes a procedure that involves administering to an opiate dependent person

Accepted Answer

A) frequent, high doses of methadone 
B) narcotic antagonists while he/she is anesthesized or heavily sedated for 24 - 48 hours 
C) morphine and naltrexone together for several hours 
D) endogenous antiopioid peptides for 24 to 48 hours 
A) frequent, high doses of methadone 
B) narcotic antagonists while he/she is anesthesized or heavily sedated for 24 - 48 hours 
C) morphine and naltrexone together for several hours 
D) endogenous antiopioid peptides for 24 to 48 hours

Question 7

The receptors upon which opiates act

Accepted Answer

A) vary in terms of their types and distribution throughout the CNS 
B) are found only in the midbrain and medulla 
C) are different from those receptors which are acted on by endogenous opioid peptides 
D) are also those for which cocaine is an agonist 
A) vary in terms of their types and distribution throughout the CNS 
B) are found only in the midbrain and medulla 
C) are different from those receptors which are acted on by endogenous opioid peptides 
D) are also those for which cocaine is an agonist

Question 8

The narcotic antagonists naloxone and naltrexone

Accepted Answer

A) will block virtually all the effects of narcotics like morphine and heroin 
B) will induce an opiate-like abstinence syndrome if taken chronically 
C) will decrease the craving for narcotics in people who have been dependent on narcotics 
D) all of the above 
A) will block virtually all the effects of narcotics like morphine and heroin 
B) will induce an opiate-like abstinence syndrome if taken chronically 
C) will decrease the craving for narcotics in people who have been dependent on narcotics 
D) all of the above

Question 9

Heroin differs from morphine primarily with respect to its

Accepted Answer

A) neuropharmacological effects 
B) relative ability to cross the blood brain barrier 
C) degree of analgesia when taken orally 
D) molecular structure 
A) neuropharmacological effects 
B) relative ability to cross the blood brain barrier 
C) degree of analgesia when taken orally 
D) molecular structure

Question 10

Newborns of narcotic dependent women

Accepted Answer

A) tend to have lower birth weights and are more excitable and irritable than normal babies 
B) show the same physical abnormalities as the fetal alcohol syndrome 
C) generally don't show any abnormal problems at birth 
D) none of the above 
A) tend to have lower birth weights and are more excitable and irritable than normal babies 
B) show the same physical abnormalities as the fetal alcohol syndrome 
C) generally don't show any abnormal problems at birth 
D) none of the above

Question 11

Chronic exposure to endorphins may result in

Accepted Answer

A) tolerance to many of their effects 
B) physical dependence 
C) opiate receptor desensitization 
D) all of these 
A) tolerance to many of their effects 
B) physical dependence 
C) opiate receptor desensitization 
D) all of these

Question 12

Which of the following is not a common effect of opiates?

Accepted Answer

A) pupillary dilation 
B) constipation 
C) decreased sex drive 
D) decreased rate of respiration 
A) pupillary dilation 
B) constipation 
C) decreased sex drive 
D) decreased rate of respiration

Question 13

Methadone is

Accepted Answer

A) more potent than heroin or morphine 
B) less potent than heroin or morphine 
C) neither a nor b because methadone is a narcotic antagonist 
D) either a or b could be true depending upon the route of administration and what the drugs are taken for 
A) more potent than heroin or morphine 
B) less potent than heroin or morphine 
C) neither a nor b because methadone is a narcotic antagonist 
D) either a or b could be true depending upon the route of administration and what the drugs are taken for

Question 14

Both methadone (Dolophine) and naltrexone (ReVia), drugs with very difference pharmacological properties, have been used in the treatment of heroin addiction.What is/are the rationales for the use of methadone and naltrexone in this problem?

Accepted Answer

Methadone and naltrexone are both orally

Question 15

Which of the following are narcotic antagonists?

Accepted Answer

A) naloxone and naltrexone 
B) methadone and LAAM 
C) clonidine and buprenorphine 
D) all of these 
A) naloxone and naltrexone 
B) methadone and LAAM 
C) clonidine and buprenorphine 
D) all of these

Question 16

Opiates have the greatest clinical efficacy in reducing ________________________.

Accepted Answer

A) sharp, fast onset pain induced by a noxious stimulus 
B) dull, aching pain that persists after a noxious stimulus has been applied 
C) both sharp, fast onset and dull, aching pain to a comparable degree 
D) non-emotional pain 
A) sharp, fast onset pain induced by a noxious stimulus 
B) dull, aching pain that persists after a noxious stimulus has been applied 
C) both sharp, fast onset and dull, aching pain to a comparable degree 
D) non-emotional pain

Question 17

Why is clonidine believed to be useful in the treatment of opiate withdrawal?

Accepted Answer

A) it reduces the hyperactivity in the locus ceruleus that accompanies opiate withdrawal 
B) it blocks opiate craving 
C) it acts at mu opiate receptors 
D) it acts on delta opiate receptors 
A) it reduces the hyperactivity in the locus ceruleus that accompanies opiate withdrawal 
B) it blocks opiate craving 
C) it acts at mu opiate receptors 
D) it acts on delta opiate receptors

Question 18

Which of the following is NOT a common effect of opiate administration?

Accepted Answer

A) analgesia 
B) constipation 
C) enhanced sex drive 
D) respiratory depression 
A) analgesia 
B) constipation 
C) enhanced sex drive 
D) respiratory depression

Question 19

A primary advantage to the use of methadone over most other narcotics like morphine and heroin

Accepted Answer

A) is its ability to be reliably absorbed when taken orally 
B) is its relatively long duration of action 
C) is its more gradual and stable effects 
D) all of the above 
A) is its ability to be reliably absorbed when taken orally 
B) is its relatively long duration of action 
C) is its more gradual and stable effects 
D) all of the above

Question 20

What are three pharmacological characteristics of buprenorphine (Suboxone, Subutex) or LAAM (Orlamm) that would make them potentially useful in the treatment of heroin addiction?

Accepted Answer

Buprenorphine is a mixed opiate agonist-

The euphorigenic properties of opiates like morphine are believed to be due to their activity at which type of receptor?

A key property of opioid drugs which underlies their addiction liability is their ability to indirectly activate _________________________ neurons projecting to the nucleus accumbens.

In the treatment of heroin addiction, the narcotic agonist LAAM (Orlamm) and the mixed agonist-antagonist buprenorphine (Suboxone, Subutex) have advantages over methadone in terms of

Which of these is the most potent and short-acting narcotic?

Which of the following has NOT been associated with the legal restrictions resulting from the Harrison Narcotic Act of 1914?

Ultrarapid opioid detoxification utilizes a procedure that involves administering to an opiate dependent person

The receptors upon which opiates act

The narcotic antagonists naloxone and naltrexone

Heroin differs from morphine primarily with respect to its

Newborns of narcotic dependent women

Chronic exposure to endorphins may result in

Which of the following is not a common effect of opiates?

Methadone is

Both methadone (Dolophine) and naltrexone (ReVia), drugs with very difference pharmacological properties, have been used in the treatment of heroin addiction.What is/are the rationales for the use of methadone and naltrexone in this problem?

Which of the following are narcotic antagonists?

Opiates have the greatest clinical efficacy in reducing ________________________.

Why is clonidine believed to be useful in the treatment of opiate withdrawal?

Which of the following is NOT a common effect of opiate administration?

A primary advantage to the use of methadone over most other narcotics like morphine and heroin

What are three pharmacological characteristics of buprenorphine (Suboxone, Subutex) or LAAM (Orlamm) that would make them potentially useful in the treatment of heroin addiction?

Psychopharmacology in Perspective

Drug Classification and Behavioral Assessment

Basic Principles of Pharmacology

Excitability and Chemical Signaling in Nerve Cells

Synaptic Transmission, Drugs, and Chemical Neuroanatomy

Tolerance, Sensitization, Dependence, and Addiction

Psychomotor Stimulants and Antiparkinsonian Drugs

Antipsychotic Drugs and Neurochemical Hypotheses of Schizophrenia

Antidepressants and Mood Stabilizers

Sedative-Hypnotics, Anxiolytics, and Anticonvulsants

Drug Treatment of Cognitive Dysfunction

Dissociative Anesthetics

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Exam 12: Naturally Occurring and Synthetic Opiates and Their Antagonists

The euphorigenic properties of opiates like morphine are believed to be due to their activity at which type of receptor?

A key property of opioid drugs which underlies their addiction liability is their ability to indirectly activate _________________________ neurons projecting to the nucleus accumbens.

In the treatment of heroin addiction, the narcotic agonist LAAM (Orlamm) and the mixed agonist-antagonist buprenorphine (Suboxone, Subutex) have advantages over methadone in terms of

Which of these is the most potent and short-acting narcotic?

Which of the following has NOT been associated with the legal restrictions resulting from the Harrison Narcotic Act of 1914?

Ultrarapid opioid detoxification utilizes a procedure that involves administering to an opiate dependent person

The receptors upon which opiates act

The narcotic antagonists naloxone and naltrexone

Heroin differs from morphine primarily with respect to its

Newborns of narcotic dependent women

Chronic exposure to endorphins may result in

Which of the following is not a common effect of opiates?

Methadone is

Both methadone (Dolophine) and naltrexone (ReVia), drugs with very difference pharmacological properties, have been used in the treatment of heroin addiction.What is/are the rationales for the use of methadone and naltrexone in this problem?

Which of the following are narcotic antagonists?

Opiates have the greatest clinical efficacy in reducing ________________________.

Why is clonidine believed to be useful in the treatment of opiate withdrawal?

Which of the following is NOT a common effect of opiate administration?

A primary advantage to the use of methadone over most other narcotics like morphine and heroin

What are three pharmacological characteristics of buprenorphine (Suboxone, Subutex) or LAAM (Orlamm) that would make them potentially useful in the treatment of heroin addiction?

Psychopharmacology in Perspective

Drug Classification and Behavioral Assessment

Basic Principles of Pharmacology

Excitability and Chemical Signaling in Nerve Cells

Synaptic Transmission, Drugs, and Chemical Neuroanatomy

Tolerance, Sensitization, Dependence, and Addiction

Psychomotor Stimulants and Antiparkinsonian Drugs

Antipsychotic Drugs and Neurochemical Hypotheses of Schizophrenia

Antidepressants and Mood Stabilizers

Sedative-Hypnotics, Anxiolytics, and Anticonvulsants

Drug Treatment of Cognitive Dysfunction

Dissociative Anesthetics

Filters