Question 1

Beta-glucuronidase is found in which subcellular fraction of the liver?

Accepted Answer

A)  Total microsomes 
B)  Lysosomes 
C)  Golgi apparatus 
D)  Mitochondria 
E)  Cytosol 
A)  Total microsomes 
B)  Lysosomes 
C)  Golgi apparatus 
D)  Mitochondria 
E)  Cytosol B

Question 2

The enzymes responsible for the degradation of sphingolipids are localized in which subcellular structure?

Accepted Answer

A)  Peroxisomes 
B)  Mitochondria 
C)  Lysosomes 
D)  Smooth endoplasmic reticulum 
E)  Rough endoplasmic reticulum 
A)  Peroxisomes 
B)  Mitochondria 
C)  Lysosomes 
D)  Smooth endoplasmic reticulum 
E)  Rough endoplasmic reticulum C

Question 3

Which type of organelle is most likely to contain a set of enzymes devoted mainly to catabolism?

Accepted Answer

A)  rough endoplasmic reticulum 
B)  smooth endoplasmic reticulum 
C)  storage granule 
D)  lysosome 
E)  Golgi apparatus 
A)  rough endoplasmic reticulum 
B)  smooth endoplasmic reticulum 
C)  storage granule 
D)  lysosome 
E)  Golgi apparatus D

Question 4

Which of the following is not true regarding water as a solvent?

Accepted Answer

A)  involves covalent interactions with the solute 
B)  water can dissolve uncharged polar molecules 
C)  hydrophilic substances readily dissolve in water 
D)  amphipathic substances have conflicting tendencies in water 
E)  water can dissolve ionic species 
A)  involves covalent interactions with the solute 
B)  water can dissolve uncharged polar molecules 
C)  hydrophilic substances readily dissolve in water 
D)  amphipathic substances have conflicting tendencies in water 
E)  water can dissolve ionic species

Question 5

Peroxisomes produce much hydrogen peroxide. How are they protected from damage by this reactive oxygen species precursor?

Accepted Answer

A)  Catalase 
B)  Glutathione peroxidase 
C)  Rapid export from the peroxisome 
D)  Rapid synthesis of new peroxisomes 
E)  Superoxide dismutase 
A)  Catalase 
B)  Glutathione peroxidase 
C)  Rapid export from the peroxisome 
D)  Rapid synthesis of new peroxisomes 
E)  Superoxide dismutase

Question 6

What is the pH of a solution of 0.01M acetic acid, 1M Na acetate? (pKa of acetic acid = 4.75)

Accepted Answer

A)  4.75 
B)  5.75 
C)  3.75 
D)  6.75 
E)  2.75 
A)  4.75 
B)  5.75 
C)  3.75 
D)  6.75 
E)  2.75

Question 7

Which of the following statements regarding pH is not true?

Accepted Answer

A)  pH = log[H+] 
B)  a ten fold change in [H+] alters the pH by 1 unit 
C)  the pH of pure water is 7 
D)  many physiological reactions are sensitive to pH 
E)  in a buffer the pH changes little with addition of small amounts of strong acid or base 
A)  pH = log[H+] 
B)  a ten fold change in [H+] alters the pH by 1 unit 
C)  the pH of pure water is 7 
D)  many physiological reactions are sensitive to pH 
E)  in a buffer the pH changes little with addition of small amounts of strong acid or base

Question 8

What is the pH of a solution in which [H+] = 10x10-9 M?

Accepted Answer

A)  6 
B)  7 
C)  8 
D)  9 
E)  1 
A)  6 
B)  7 
C)  8 
D)  9 
E)  1

Question 9

What is the ratio of protonated to unprotonated lactic acid in a 0.1 M solution of lactic acid at pH 5.86? (pKa of lactic acid is 3.86)

Accepted Answer

A)  1:100 
B)  1:10 
C)  1:1 
D)  10:1 
E)  (1:1) 
A)  1:100 
B)  1:10 
C)  1:1 
D)  10:1 
E)  (1:1)

Question 10

What is the cause of I cell disease?

Accepted Answer

A)  Failure of targeting of enzymes to lysosomes 
B)  Impermeability of lysosomal membranes 
C)  Import of extracellular hydrolytic enzymes 
D)  Lack of primary lysosomes 
E)  Products of lysosomal hydrolysis accumulate in lysosomes 
A)  Failure of targeting of enzymes to lysosomes 
B)  Impermeability of lysosomal membranes 
C)  Import of extracellular hydrolytic enzymes 
D)  Lack of primary lysosomes 
E)  Products of lysosomal hydrolysis accumulate in lysosomes

Question 11

Which of the following membrane systems are responsible for the bulk of cellular protein and lipid synthesis?

Accepted Answer

A)  Plasma membrane 
B)  Microbodies 
C)  Lysosomes 
D)  Endoplasmic reticulum 
E)  Golgi complex 
A)  Plasma membrane 
B)  Microbodies 
C)  Lysosomes 
D)  Endoplasmic reticulum 
E)  Golgi complex

Question 12

The principal type of reaction carried out by lysosomal enzymes is

Accepted Answer

A)  phosphorolysis. 
B)  dehydration. 
C)  dehydrogenation. 
D)  hydroxylation. 
E)  hydrolysis. 
A)  phosphorolysis. 
B)  dehydration. 
C)  dehydrogenation. 
D)  hydroxylation. 
E)  hydrolysis.

Question 13

What is required for the formation of a hydrogen bond?

Accepted Answer

A)  A carboxyl group as acceptor 
B)  A hydrogen attached to an electronegative atom 
C)  A hydrogen in the proximity of a nitrogen atom 
D)  A hydrogen that is a part of a double bond 
E)  A hydrogen that is part of an aliphatic compound 
A)  A carboxyl group as acceptor 
B)  A hydrogen attached to an electronegative atom 
C)  A hydrogen in the proximity of a nitrogen atom 
D)  A hydrogen that is a part of a double bond 
E)  A hydrogen that is part of an aliphatic compound

Question 14

To make an acetate buffer at pH 3.7, what is the required ratio of sodium acetate to acetic acid? (pKa of acetic acid is 4.7)

Accepted Answer

A)  100:1 
B)  10:1 
C)  1:1 
D)  1:10 
E)  (1:1) 
A)  100:1 
B)  10:1 
C)  1:1 
D)  1:10 
E)  (1:1)

Exam 1: Eukaryotic Cell Structure

Beta-glucuronidase is found in which subcellular fraction of the liver?

The enzymes responsible for the degradation of sphingolipids are localized in which subcellular structure?

Which type of organelle is most likely to contain a set of enzymes devoted mainly to catabolism?

Which of the following is not true regarding water as a solvent?

Peroxisomes produce much hydrogen peroxide. How are they protected from damage by this reactive oxygen species precursor?

What is the pH of a solution of 0.01M acetic acid, 1M Na acetate? (pKa of acetic acid = 4.75)

Which of the following statements regarding pH is not true?

What is the pH of a solution in which [H+] = 10x10-9 M?

What is the ratio of protonated to unprotonated lactic acid in a 0.1 M solution of lactic acid at pH 5.86? (pKa of lactic acid is 3.86)

What is the cause of I cell disease?

Which of the following membrane systems are responsible for the bulk of cellular protein and lipid synthesis?

The principal type of reaction carried out by lysosomal enzymes is

What is required for the formation of a hydrogen bond?

To make an acetate buffer at pH 3.7, what is the required ratio of sodium acetate to acetic acid? (pKa of acetic acid is 4.7)

DNA and RNA: Composition and Structure

Protein I: Composition and Structure

DNA Replication, Recombination, and Repair

RNA: Transcription and Rna Processing

Protein Synthesis: Translation and Posttranslational Modifications

Recombinant Dna and Biotechnology

Regulation of Gene Expression

Protein II: Structure-Function Relationships in Protein Families

Enzymes: Classification, Kinetics, and Control

The Cytochromes P450 and Nitric Oxide Synthases

Biological Membranes: Structure and Membrane Transport

Fundamentals of Signal Transduction

Bioenergetics and Oxidative Metabolism

Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control

Carbohydrate Metabolism II: Special Pathways and Glycoconjugates

Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols

Lipid Metabolism II: Pathways of Metabolism of Special Lipids

Amino Acid Metabolism

Purine and Pyrimidine Nucleotide Metabolism

Metabolic Interrelationships

Biochemistry of Hormones

Molecular Cell Biology

Cell Cycle, Programmed Cell Death, and Cancer

Digestion and Absorption of Basic Nutritional Constituents

Digestion and Absorption of Basic Nutritional Constituents

Principles of Nutrition I and II

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