Outline a Synthesis for the Transformation Using the Indicated Starting

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The Answer is Working backward, the product has added a carbon to the starting material. The product is an amide, so the precursor might have been a carboxylic acid. The precursor to a carboxylic acid could have been a Grignard with CO₂. The Grignard would come from an alkyl halide, which could come from the addition of HBr to the starting alkene.

Working backward, the product has added a carbon to the starting material. The product is an amide, so the precursor might have been a carboxylic acid. The precursor to a carboxylic acid could have been a Grignard with CO<sub>2</sub>. The Grignard would come from an alkyl halide, which could come from the addition of HBr to the starting alkene. Note that the starting material contains a carbonyl that is not changed throughout the synthesis, but would be reactive with the Grignard reagent, so it needs to be protected. The synthesis in the forward direction would be:

Note that the starting material contains a carbonyl that is not changed throughout the synthesis, but would be reactive with the Grignard reagent, so it needs to be protected. The synthesis in the forward direction would be:

Outline a Synthesis for the Transformation Using the Indicated Starting

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Outline a Synthesis for the Transformation Using the Indicated Starting

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Correct Answer:
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