The Integrin LFA-1 Is Constitutively Expressed on the Surface of Resting

Multiple Choice

The integrin LFA-1 is constitutively expressed on the surface of resting T cells. Yet, integrin-dependent T cell adhesion to antigen-presenting cells increases substantially following TCR stimulation. This increased integrin-dependent adhesion is mediated in part by:

A) Increased synthesis of the LFA-1 protein
B) Increased transport of intracellular pools of LFA-1 to the cell surface
C) LFA-1 conversion to a high affinity binding state
D) Increased phosphorylation of the LFA-1 cytoplasmic tail
E) Activation of cdc42 and WASp