Human Patients with Genetic Defects That Result in a Failure

Multiple Choice

Human patients with genetic defects that result in a failure to produce the calcium channel protein ORAI1, or the ER calcium sensor protein STIM1, have severe immunodeficiency diseases. An immunosuppressive drug that would most closely mimic these primary immunodeficiencies is:

A) Rituximab, a drug that depletes B cells
B) Cyclosporin A, a calcineurin inhibitor
C) Rapamycin, an mTOR inhibitor
D) Tysabri, an inhibitor of integrin binding
E) Enbrel or Humira that inhibit TNF