Exam 16: Hypoproliferative Anemias

A 3-month-old infant is exhibiting pallor and fatigue. The pediatrician orders a CBC, which displays a low RBC count, H&H, and normal WBC and PLT counts. EPO levels are increased. BM aspirate shows prominent erythroid hypoplasia. Cytogenetic analysis reveals the presence of RPS19 mutation. Based on these findings, what is the patient most likely suffering from?

Hypoproliferative anemia is defined as:

Which of the following is among the diagnostic criteria for aplastic anemia?

Which of the following contributes to the production of hypocellular bone marrow?

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not? Susceptible individuals have:

Patients with renal disease are at risk for developing megaloblastic anemia because of:

What CBC parameter would help differentiate Fanconi's syndrome from Diamond-Blackfan anemia?

Fanconi's syndrome is an example of:

Correlate the prognosis associated with the following treatments for aplastic anemia. a. Bone marrow transplant b. Cytokine therapy c. Stem cell transplant d. Immunosuppression therapy

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages. What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia. What is the most probable defect causing this rare disorder?