Question 1

Explain why patients undergoing gastric bypass surgery are prone to developing pernicious anemia.

Accepted Answer

Gastric bypass involves resection of the

Question 2

Predict the levels of MMA and homocysteine in patients with Vitamin B12 deficiency.

Accepted Answer

A)  Both will be normal. 
B)  Both will be decreased. 
C)  Both will be increased. 
D)  MMA will be increased and homocysteine will be normal. 
A)  Both will be normal. 
B)  Both will be decreased. 
C)  Both will be increased. 
D)  MMA will be increased and homocysteine will be normal.

Question 3

The reason that lack of vitamin B12 causes megaloblastic changes is that vitamin B12:

Accepted Answer

A)  Is needed for the formation of nucleotide bases 
B)  Is needed for the conversion of methionine to SAM 
C)  Initiates mitosis 
D)  Is needed for synthesis of intrinsic factor 
A)  Is needed for the formation of nucleotide bases 
B)  Is needed for the conversion of methionine to SAM 
C)  Initiates mitosis 
D)  Is needed for synthesis of intrinsic factor

Question 4

Neurological symptoms are prevalent in Vitamin B12 deficiency because of:

Accepted Answer

A)  Antibodies to intrinsic factor 
B)  Decreased secretion of intrinsic factor 
C)  Improper fatty acid metabolism 
D)  Improper metabolism of methionine 
A)  Antibodies to intrinsic factor 
B)  Decreased secretion of intrinsic factor 
C)  Improper fatty acid metabolism 
D)  Improper metabolism of methionine

Question 5

What would be the results of vitamin B12 and/or folate levels in a diagnosis of pernicious anemia?

Accepted Answer

A)  Increased folate 
B)  Increased vitamin B12 
C)  Decreased vitamin B12 
D)  Decreased folate and vitamin B12  
A)  Increased folate 
B)  Increased vitamin B12 
C)  Decreased vitamin B12 
D)  Decreased folate and vitamin B12

Question 6

Which test is a better indicator of folate status in the body over the past month?

Accepted Answer

A)  Folate level 
B)  RBC folate level 
C)  Vitamin B12 level 
D)  MMA 
A)  Folate level 
B)  RBC folate level 
C)  Vitamin B12 level 
D)  MMA

Question 7

It is much easier to become folate-deficient than B12-deficient because:

Accepted Answer

A)  The body utilizes folate more quickly than it does vitamin B12 
B)  The body has larger vitamin B12 stores than folate stores 
C)  The body has a greater need for folate than for vitamin B12 
D)  It has not been determined why the body needs folate more than vitamin B12 
A)  The body utilizes folate more quickly than it does vitamin B12 
B)  The body has larger vitamin B12 stores than folate stores 
C)  The body has a greater need for folate than for vitamin B12 
D)  It has not been determined why the body needs folate more than vitamin B12

Question 8

What can falsely elevate the serum folate level?

Accepted Answer

A)  Hemolysis of the serum sample 
B)  Recent low dietary intake 
C)  Vitamin B12 deficiency 
D)  Recent alcohol consumption 
A)  Hemolysis of the serum sample 
B)  Recent low dietary intake 
C)  Vitamin B12 deficiency 
D)  Recent alcohol consumption

Question 9

The majority of PA patients have antibodies against what component necessary for vitamin B12 absorption?

Accepted Answer

A)  Parietal cells 
B)  Vitamin B12 
C)  Intrinsic factor 
D)  Blocking antibody 
A)  Parietal cells 
B)  Vitamin B12 
C)  Intrinsic factor 
D)  Blocking antibody

Question 10

Deficiencies in folic acid lead to which of the following?

Accepted Answer

A)  Nuclear cytoplasmic asynchrony 
B)  Absence of nuclear division 
C)  Excessive proliferation of myeloid precursors 
D)  Decreased proliferation of erythroid precursors 
A)  Nuclear cytoplasmic asynchrony 
B)  Absence of nuclear division 
C)  Excessive proliferation of myeloid precursors 
D)  Decreased proliferation of erythroid precursors

Question 11

Pernicious anemia is a disorder characterized by:

Accepted Answer

A)  Antivitamin B12 antibodies 
B)  Lack of IF 
C)  Improper dietary intake of vitamin B12 
D)  Increased absorption of vitamin B12 
A)  Antivitamin B12 antibodies 
B)  Lack of IF 
C)  Improper dietary intake of vitamin B12 
D)  Increased absorption of vitamin B12

Question 12

The nuclear cytoplasmic asynchronous morphology in megaloblastosis is best characterized by:

Accepted Answer

A)  Nuclear immaturity with cytoplasmic maturity 
B)  Nuclear maturity with cytoplasmic immaturity 
C)  Nuclear maturity with abundant cytoplasm 
D)  Normal nuclear and cytoplasmic maturity 
A)  Nuclear immaturity with cytoplasmic maturity 
B)  Nuclear maturity with cytoplasmic immaturity 
C)  Nuclear maturity with abundant cytoplasm 
D)  Normal nuclear and cytoplasmic maturity

Question 13

Explain why peripheral neuropathy is a common finding in vitamin B12 deficiency is.

Accepted Answer

In vitamin B₁₂ deficiency, there is a defe

Exam 15: Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Explain why patients undergoing gastric bypass surgery are prone to developing pernicious anemia.

Predict the levels of MMA and homocysteine in patients with Vitamin B12 deficiency.

The reason that lack of vitamin B12 causes megaloblastic changes is that vitamin B12:

Neurological symptoms are prevalent in Vitamin B12 deficiency because of:

What would be the results of vitamin B12 and/or folate levels in a diagnosis of pernicious anemia?

Which test is a better indicator of folate status in the body over the past month?

It is much easier to become folate-deficient than B12-deficient because:

What can falsely elevate the serum folate level?

The majority of PA patients have antibodies against what component necessary for vitamin B12 absorption?

Deficiencies in folic acid lead to which of the following?

Pernicious anemia is a disorder characterized by:

The nuclear cytoplasmic asynchronous morphology in megaloblastosis is best characterized by:

Explain why peripheral neuropathy is a common finding in vitamin B12 deficiency is.

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters

Predict the levels of MMA and homocysteine in patients with Vitamin B₁₂ deficiency.

The reason that lack of vitamin B₁₂ causes megaloblastic changes is that vitamin B₁₂:

Neurological symptoms are prevalent in Vitamin B₁₂ deficiency because of:

What would be the results of vitamin B₁₂ and/or folate levels in a diagnosis of pernicious anemia?

It is much easier to become folate-deficient than B₁₂-deficient because:

The majority of PA patients have antibodies against what component necessary for vitamin B₁₂ absorption?