Question 1

A patient experiencing compensated hemolytic disease would show which of the following lab results?

Accepted Answer

A)  RBC count: 2.8 × 1012/L 
B)  MCV: 73 fL 
C)  MCHC: 28 g/dL 
D)  Hb 15.4 g/dL 
A)  RBC count: 2.8 × 1012/L 
B)  MCV: 73 fL 
C)  MCHC: 28 g/dL 
D)  Hb 15.4 g/dL

Question 2

Blood flow adaptations to anemia are achieved by increasing the respiration rate and:

Accepted Answer

A)  Increasing the circulation rate 
B)  Decreasing 2,3-BPG 
C)  Decreasing cardiac output 
D)  Increasing blood viscosity 
A)  Increasing the circulation rate 
B)  Decreasing 2,3-BPG 
C)  Decreasing cardiac output 
D)  Increasing blood viscosity

Question 3

Explain how the sensitivity and specificity of a laboratory test can be used to screen and confirm a differential diagnosis of anemia.

Accepted Answer

A highly sensitive test would likely be

Question 4

A 34-year-old woman has severe anemia. She complains of a feeling of fullness and splenomegaly. This diagnosis and clinical symptoms indicate:

Accepted Answer

A)  a chronic hemolytic process 
B)  an acute hemolytic anemia 
C)  intravascular hemolysis 
D)  extravascular hemolysis 
A)  a chronic hemolytic process 
B)  an acute hemolytic anemia 
C)  intravascular hemolysis 
D)  extravascular hemolysis

Question 5

How would you classify an anemic patient whose reticulocyte count is 0.5%?

Accepted Answer

A)  Hypoproliferative 
B)  Extravascular hemolytic 
C)  Maturation defect 
D)  Survival defect 
A)  Hypoproliferative 
B)  Extravascular hemolytic 
C)  Maturation defect 
D)  Survival defect

Question 6

Microcytic hypochromic anemias are associated with which functional abnormality?

Accepted Answer

A)  Defective folate utilization 
B)  Bone marrow hypoplasia 
C)  Fibrotic bone marrow 
D)  Defective hemoglobin synthesis 
A)  Defective folate utilization 
B)  Bone marrow hypoplasia 
C)  Fibrotic bone marrow 
D)  Defective hemoglobin synthesis

Question 7

Normal hematocrit is 45%. What is the RPI for this patient with a reticulocyte count of 5% and hematocrit of 25%?

Accepted Answer

A)  2.39 
B)  2.59 
C)  1.39 
D)  4.50 
A)  2.39 
B)  2.59 
C)  1.39 
D)  4.50

Question 8

An increased IRF is not seen in which of the following?

Accepted Answer

A)  Erythropoietin therapy 
B)  Iron therapy in iron deficient patients 
C)  Bone marrow recovery post-transplant 
D)  Aplastic anemia 
A)  Erythropoietin therapy 
B)  Iron therapy in iron deficient patients 
C)  Bone marrow recovery post-transplant 
D)  Aplastic anemia

Question 9

Which of the following laboratory tests could be used to help identify the cause of an anemia?

Accepted Answer

A)  Platelet count 
B)  Haptoglobin concentration 
C)  RBC count 
D)  Absolute lymphocyte count 
A)  Platelet count 
B)  Haptoglobin concentration 
C)  RBC count 
D)  Absolute lymphocyte count

Question 10

All of the following are classic signs of anemia except:

Accepted Answer

A)  Fatigue 
B)  Pallor 
C)  Shortness of breath 
D)  Nosebleeds 
A)  Fatigue 
B)  Pallor 
C)  Shortness of breath 
D)  Nosebleeds

Question 11

An apparent pancytopenia is noted in a patient's CBC results. A bone marrow aspirate is performed, and the M:E results are 2:1. Do these results make sense? Why or why not?

Accepted Answer

Yes, these results make sense. The M:E r

Question 12

A patient experiencing intravascular hemolysis would likely show which of the following:

Accepted Answer

A)  Leukocytosis 
B)  Decreased reticulocyte count 
C)  Hemosiderinuria 
D)  Negative DAT 
A)  Leukocytosis 
B)  Decreased reticulocyte count 
C)  Hemosiderinuria 
D)  Negative DAT

Question 13

Which of the following is best to measure RBC survival?

Accepted Answer

A)  Using conjugated bilirubin 
B)  Using urine hemoglobin 
C)  Monitoring 51Cr labeled RBCs 
D)  Using reticulocyte count 
A)  Using conjugated bilirubin 
B)  Using urine hemoglobin 
C)  Monitoring 51Cr labeled RBCs 
D)  Using reticulocyte count

Question 14

Patient results indicate an RPI of 1.8 and an MCV of 109 fl. Do these results make sense? Why or why not?

Accepted Answer

Yes, these results make sense. This is t

Exam 11: Introduction to Anemia

A patient experiencing compensated hemolytic disease would show which of the following lab results?

Blood flow adaptations to anemia are achieved by increasing the respiration rate and:

Explain how the sensitivity and specificity of a laboratory test can be used to screen and confirm a differential diagnosis of anemia.

A 34-year-old woman has severe anemia. She complains of a feeling of fullness and splenomegaly. This diagnosis and clinical symptoms indicate:

How would you classify an anemic patient whose reticulocyte count is 0.5%?

Microcytic hypochromic anemias are associated with which functional abnormality?

Normal hematocrit is 45%. What is the RPI for this patient with a reticulocyte count of 5% and hematocrit of 25%?

An increased IRF is not seen in which of the following?

Which of the following laboratory tests could be used to help identify the cause of an anemia?

All of the following are classic signs of anemia except:

An apparent pancytopenia is noted in a patient's CBC results. A bone marrow aspirate is performed, and the M:E results are 2:1. Do these results make sense? Why or why not?

A patient experiencing intravascular hemolysis would likely show which of the following:

Which of the following is best to measure RBC survival?

Patient results indicate an RPI of 1.8 and an MCV of 109 fl. Do these results make sense? Why or why not?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters