Question 1

A patient has a serum iron of 10 g/dL and a total iron-binding capacity (TIBC)of 490 g/dL.What is the percent saturation of transferrin?

Accepted Answer

A) 2% 
B) 25% 
C) 40% 
D) 60% 
A) 2% 
B) 25% 
C) 40% 
D) 60% A

Question 2

What is the plasma carrier protein for iron?

Accepted Answer

A) apoferritin 
B) apotransferrin 
C) albumin 
D) hemosiderin 
A) apoferritin 
B) apotransferrin 
C) albumin 
D) hemosiderin B

Question 3

Which two organs are the major storage sites for iron in a normal individual?

Accepted Answer

A) lymph nodes and muscle 
B) bone marrow and pancreas 
C) spleen and heart 
D) liver and spleen 
A) lymph nodes and muscle 
B) bone marrow and pancreas 
C) spleen and heart 
D) liver and spleen D

Question 4

Acute (24-hour)assessment of the amount of iron that is available for hemoglobin production is best identified by measuring the

Accepted Answer

A) sTfR levels on the cell membrane. 
B) amount of hemoglobin in reticulocytes. 
C) amount of hemosiderin with Prussian blue stain. 
D) zinc protoporphyrin levels in red blood cells. 
A) sTfR levels on the cell membrane. 
B) amount of hemoglobin in reticulocytes. 
C) amount of hemosiderin with Prussian blue stain. 
D) zinc protoporphyrin levels in red blood cells.

Question 5

Which of the following is true for apotransferrin?

Accepted Answer

A) It can bind two molecules of ferric iron. 
B) It binds to a ferritin receptor found on the cell membrane. 
C) It is synthesized in the kidney. 
D) It is normally about 50% saturated with iron. 
A) It can bind two molecules of ferric iron. 
B) It binds to a ferritin receptor found on the cell membrane. 
C) It is synthesized in the kidney. 
D) It is normally about 50% saturated with iron.

Question 6

The serum iron and TIBC results given in Question 7 are consistent with:

Accepted Answer

A) iron overload. 
B) iron toxicity. 
C) iron deficiency. 
D) acute infection. 
A) iron overload. 
B) iron toxicity. 
C) iron deficiency. 
D) acute infection.

Question 7

What is the mechanism for iron toxicity if iron is present in excess amounts?

Accepted Answer

A) acts as a catalyst in forming hydroxyl (free) radicals 
B) impedes hematopoiesis 
C) reduces hemoglobin to methemoglobin 
D) interferes with globin synthesis 
A) acts as a catalyst in forming hydroxyl (free) radicals 
B) impedes hematopoiesis 
C) reduces hemoglobin to methemoglobin 
D) interferes with globin synthesis

Question 8

Where is the largest percentage of iron in the body located?

Accepted Answer

A) stored in the bone marrow 
B) stored in the liver 
C) attached to hemoglobin in erythrocytes 
D) in the cytoplasm of macrophages 
A) stored in the bone marrow 
B) stored in the liver 
C) attached to hemoglobin in erythrocytes 
D) in the cytoplasm of macrophages

Question 9

The serum ferritin is used more often than bone marrow or liver biopsies to assess iron stores because it is

Accepted Answer

A) a more direct measurement. 
B) more accurate. 
C) more precise. 
D) less invasive. 
A) a more direct measurement. 
B) more accurate. 
C) more precise. 
D) less invasive.

Question 10

Select the condition where an acute increase in ferritin levels can be detected without a specific increase in the amount of systemic body iron?

Accepted Answer

A) myocardial infarction 
B) bacterial infection 
C) malignancy 
D) liver disease 
A) myocardial infarction 
B) bacterial infection 
C) malignancy 
D) liver disease

Question 11

Heme is composed of iron and

Accepted Answer

A) globin chains. 
B) oxygen. 
C) methemoglobin. 
D) protoporphyrin IX. 
A) globin chains. 
B) oxygen. 
C) methemoglobin. 
D) protoporphyrin IX.

Question 12

Good dietary sources of iron include all except

Accepted Answer

A) meat. 
B) fruit. 
C) fortified flour. 
D) legumes. 
A) meat. 
B) fruit. 
C) fortified flour. 
D) legumes.

Question 13

Soluble transferrin receptor (sTfR)levels increase when intracellular iron levels are

Accepted Answer

A) decreased. 
B) elevated. 
C) constant. 
D) both a and b. 
A) decreased. 
B) elevated. 
C) constant. 
D) both a and b.

Question 14

Which of the following stains blue with the Prussian blue stain?

Accepted Answer

A) ferritin 
B) hemosiderin 
C) transferrin 
D) both ferritin and hemosiderin 
A) ferritin 
B) hemosiderin 
C) transferrin 
D) both ferritin and hemosiderin

Exam 11: Iron Kinetics and Laboratory Assessment

A patient has a serum iron of 10 g/dL and a total iron-binding capacity (TIBC)of 490 g/dL.What is the percent saturation of transferrin?

What is the plasma carrier protein for iron?

Which two organs are the major storage sites for iron in a normal individual?

Acute (24-hour)assessment of the amount of iron that is available for hemoglobin production is best identified by measuring the

Which of the following is true for apotransferrin?

The serum iron and TIBC results given in Question 7 are consistent with:

What is the mechanism for iron toxicity if iron is present in excess amounts?

Where is the largest percentage of iron in the body located?

The serum ferritin is used more often than bone marrow or liver biopsies to assess iron stores because it is

Select the condition where an acute increase in ferritin levels can be detected without a specific increase in the amount of systemic body iron?

Heme is composed of iron and

Good dietary sources of iron include all except

Soluble transferrin receptor (sTfR)levels increase when intracellular iron levels are

Which of the following stains blue with the Prussian blue stain?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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