Question 1

Which cells are responsible for antibody production?

Accepted Answer

A) macrophages 
B) monocytes 
C) neutrophils 
D) plasma cells 
A) macrophages 
B) monocytes 
C) neutrophils 
D) plasma cells D

Question 2

Mature mast cells are

Accepted Answer

A) leukocytes. 
B) tissue effector cells. 
C) progenitor cells. 
D) cytokines. 
A) leukocytes. 
B) tissue effector cells. 
C) progenitor cells. 
D) cytokines. B

Question 3

A segmented neutrophil performs all of the following except

Accepted Answer

A) chemotaxis. 
B) phagocytosis. 
C) mitosis. 
D) pinocytosis. 
A) chemotaxis. 
B) phagocytosis. 
C) mitosis. 
D) pinocytosis. C

Question 4

Response to parasitic infections is associated with an increase of which type of granulocyte?

Accepted Answer

A) promyelocytes 
B) band neutrophils 
C) segmented neutrophils 
D) eosinophils 
A) promyelocytes 
B) band neutrophils 
C) segmented neutrophils 
D) eosinophils

Question 5

Which of the following neutrophils is capable of chemotaxis?

Accepted Answer

A) stem cell 
B) progenitor cell 
C) myelocyte 
D) segmented neutrophil 
A) stem cell 
B) progenitor cell 
C) myelocyte 
D) segmented neutrophil

Question 6

Which of the following is a feature of a normal segmented neutrophil?

Accepted Answer

A) basophilic cytoplasm 
B) round nucleus with fine chromatin 
C) small pink-lilac granules 
D) prominent primary granules 
A) basophilic cytoplasm 
B) round nucleus with fine chromatin 
C) small pink-lilac granules 
D) prominent primary granules

Question 7

What pools of neutrophils are included in the marginal neutrophil pool (MNP)?

Accepted Answer

A) all neutrophils inside the blood vessels 
B) only freely circulating neutrophils 
C) only cells loosely localized to the vessel walls 
D) all leukocytes in the body 
A) all neutrophils inside the blood vessels 
B) only freely circulating neutrophils 
C) only cells loosely localized to the vessel walls 
D) all leukocytes in the body

Question 8

What is the earliest stage of maturation where a neutrophil can be distinguished from an eosinophil?

Accepted Answer

A) myeloblast 
B) CFU-GEMM 
C) metamyelocyte 
D) myelocyte 
A) myeloblast 
B) CFU-GEMM 
C) metamyelocyte 
D) myelocyte

Question 9

Which cells are normally produced in multiple sites including the bone marrow,thymus,and spleen?

Accepted Answer

A) monocytes 
B) lymphocytes 
C) eosinophils 
D) basophils 
A) monocytes 
B) lymphocytes 
C) eosinophils 
D) basophils

Question 10

What is the last granulocyte in the maturation sequence able to undergo mitosis?

Accepted Answer

A) myeloblast 
B) promyelocyte 
C) myelocyte 
D) band 
A) myeloblast 
B) promyelocyte 
C) myelocyte 
D) band

Question 11

B cells and T cells are subgroups of what cell type?

Accepted Answer

A) monocytes 
B) lymphocytes 
C) macrophages 
D) plasma cells 
A) monocytes 
B) lymphocytes 
C) macrophages 
D) plasma cells

Question 12

A cell having a round nucleus with delicate chromatin,two to four prominent nucleoli,and a high N:C ratio of 8:1 with scant basophilic cytoplasm is an accurate description of a

Accepted Answer

A) myeloblast. 
B) myelocyte. 
C) metamyelocyte. 
D) band. 
A) myeloblast. 
B) myelocyte. 
C) metamyelocyte. 
D) band.

Question 13

Select the correct maturation sequence for granulocytes starting with youngest.

Accepted Answer

A) promyelocyte, myeloblast, metamyelocyte, myelocyte, segmented 
B) myeloblast, promyelocyte, myelocyte, metamyelocyte, band, segmented 
C) segmented, band, metamyelocyte, myelocyte, promyelocyte, myeloblast 
D) CFU-GEMM, promyelocyte, metamyelocyte, myelocyte, segmented 
A) promyelocyte, myeloblast, metamyelocyte, myelocyte, segmented 
B) myeloblast, promyelocyte, myelocyte, metamyelocyte, band, segmented 
C) segmented, band, metamyelocyte, myelocyte, promyelocyte, myeloblast 
D) CFU-GEMM, promyelocyte, metamyelocyte, myelocyte, segmented

Question 14

What is the primary function of the neutrophils?

Accepted Answer

A) antibody production 
B) phagocytosis 
C) kill parasites 
D) respond to allergens 
A) antibody production 
B) phagocytosis 
C) kill parasites 
D) respond to allergens

Question 15

Which of the following cells is described as a large cell with abundant blue-grey cytoplasm containing minute granules,lacy or stringy chromatin,and an indented or folded nucleus?

Accepted Answer

A) monocyte 
B) macrophage 
C) lymphocyte 
D) basophil 
A) monocyte 
B) macrophage 
C) lymphocyte 
D) basophil

Question 16

Why is the bone marrow (storage)pool of granulocytes so large compared with the total number found in peripheral blood?

Accepted Answer

A) They prefer bone marrow to peripheral blood. 
B) They can be quickly released when needed to fight bacterial infection. 
C) It enhances their ability to function. 
D) It prolongs their lifespan in circulation. 
A) They prefer bone marrow to peripheral blood. 
B) They can be quickly released when needed to fight bacterial infection. 
C) It enhances their ability to function. 
D) It prolongs their lifespan in circulation.

Question 17

What directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow?

Accepted Answer

A) erythropoietin. 
B) the number of stem cells. 
C) the number of mature cells in the peripheral circulation. 
D) colony-stimulating factor cytokines. 
A) erythropoietin. 
B) the number of stem cells. 
C) the number of mature cells in the peripheral circulation. 
D) colony-stimulating factor cytokines.

Question 18

When monocytes reside in the tissues they are referred to as

Accepted Answer

A) mast cells. 
B) T cells. 
C) plasma cells. 
D) macrophages. 
A) mast cells. 
B) T cells. 
C) plasma cells. 
D) macrophages.

Question 19

Which of the following has the most controversial morphologic identification system?

Accepted Answer

A) progenitor cells 
B) stem cells 
C) promyelocytes 
D) bands 
A) progenitor cells 
B) stem cells 
C) promyelocytes 
D) bands

Question 20

What is the earliest morphologically identifiable cell in the granulocyte maturation sequence?

Accepted Answer

A) hematopoietic stem cell 
B) colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM) 
C) myeloblast 
D) myelocyte 
A) hematopoietic stem cell 
B) colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM) 
C) myeloblast 
D) myelocyte

Exam 12: Leukocyte Development, Kinetics, and Functions

Which cells are responsible for antibody production?

Mature mast cells are

A segmented neutrophil performs all of the following except

Response to parasitic infections is associated with an increase of which type of granulocyte?

Which of the following neutrophils is capable of chemotaxis?

Which of the following is a feature of a normal segmented neutrophil?

What pools of neutrophils are included in the marginal neutrophil pool (MNP)?

What is the earliest stage of maturation where a neutrophil can be distinguished from an eosinophil?

Which cells are normally produced in multiple sites including the bone marrow,thymus,and spleen?

What is the last granulocyte in the maturation sequence able to undergo mitosis?

B cells and T cells are subgroups of what cell type?

A cell having a round nucleus with delicate chromatin,two to four prominent nucleoli,and a high N:C ratio of 8:1 with scant basophilic cytoplasm is an accurate description of a

Select the correct maturation sequence for granulocytes starting with youngest.

What is the primary function of the neutrophils?

Which of the following cells is described as a large cell with abundant blue-grey cytoplasm containing minute granules,lacy or stringy chromatin,and an indented or folded nucleus?

Why is the bone marrow (storage)pool of granulocytes so large compared with the total number found in peripheral blood?

What directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow?

When monocytes reside in the tissues they are referred to as

Which of the following has the most controversial morphologic identification system?

What is the earliest morphologically identifiable cell in the granulocyte maturation sequence?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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