Exam 21: Toxicity to Neuroendocrine Organs and Endocrine Disruption

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The adrenal effects could just be a stress response. How can a scientist differentiate between stress and endocrine disruption in this organ?

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Lesions are not stress nor are cancers. Some agents such as short-chain aliphatics produce lipidosis. Mitochondrial poisons affect adrenal function and vacuolar or granular degeneration ormay result from exposure of mitochondria in the adrenal to α-[1,4-dioxido-3-methylquinoxalin-2-yl]-N-methylnitrone. Chronic damage yields atrophy, fibrosis, and nodular hyperplasia.

Why is vitellogenin expression a measure of endocrine disruption?

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This yolk protein should not be present in males and should not be overproduced in females. Feminization is a sign of estrogenic endocrine disruption.

What is a good model of thyroid disruption?

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Frog metamorphosis as thyroid disruptors make for large tadpoles who don't metamorphose into frogs.

What discontinued persistent chlorinated pesticide affected GnRH?

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