Exam 1: A Case for Evolutionary Thinking: Understanding HIV

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In what region of the world is the incidence of infection with HIV highest?

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In which of the following regions has AIDS killed the largest number of individuals?

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What is the function of the product of the viral gene vpu in human infections of HIV?

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The proteins that enable the HIV virus to bind to cells are typically CD4 and CCR5.On what type of cells are these proteins typically observed?

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Tetherin is an important protein produced by the host.What is the function of tetherin in protecting a host cell from HIV?

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Originally,HIV was thought to be restricted to transmission during homosexual contact between gay men.List other ways in which HIV is currently known to be transmitted.

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Following long periods of infection with HIV,an X4 strain often evolves.What evolutionary advantage does the X4 strain confer on the viral population,and what specific protein does this strain interact with?

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Antibodies and killer T cells recognize HIV or HIV-infected cells by binding to short pieces of viral proteins displayed on the virus or the infected host cell.These short pieces of viral proteins are called ________.

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What is the effect of the ∆32 allele of CCR5 on HIV binding?

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When AZT is used to treat HIV infections,why does resistance to AZT usually develop?

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