Exam 6: Mendelian Genetics in Populations I: Selection and Mutation

Cystic fibrosis is one of the most common genetic diseases among individuals of European ancestry,and affects one newborn in approximately how many?

In experiments with laboratory populations of Drosophila melanogaster,Mukai and Burdick (1959)observed that a lethal allele maintained a higher than expected frequency.The explanation for this observation is that,at equilibrium,the selective advantage of the lethal allele when it occurs in heterozygotes balances the disadvantage of the allele in homozygotes,and is termed ________.

The Hardy-Weinberg equilibrium principle is known as the null hypothesis.List the five assumptions that are required for a population to be in Hardy-Weinberg equilibrium.

In the mating of an Aa female and an Aa male,the genotypic outcome predicted by a Punnett square is ________.

Explain the consequence of overdominance in maintaining a deleterious allele in a population as it relates to genetic diversity.

Explain the significance of the experiments of Mukai and Burdick (1959)with laboratory populations of Drosophila melanogaster using the V (viable)and L (lethal)alleles.Be sure to explain their observation that a lethal allele was maintained at a higher than expected frequency,and the evolutionary significance of overdominance in these populations.

Cystic fibrosis is caused by a recessive loss-of-function mutation that encodes a protein called the ________.

The Hardy-Weinberg equilibrium principle is often referred to as the ________,[two words] which indicates that if a population is in Hardy-Weinberg equilibrium,that population is not evolving.

In biallelic populations,where allelic frequencies are indicated by p and q,the resultant genotype frequencies are indicated by what algebraic formula?

The point at which the rate that a deleterious allele is being eliminated from a population by natural selection is in equilibrium with the rate at which the deleterious allele is being replaced by a new mutation is termed ________.