Exam 1: Activation of T Lymphocytes

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -This molecule is a transcription factor involved in the expression of several T cell activation genes activated when its bound inhibitor is phosphorylated.

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -This is a transcription factor that exists in the phosphorylated form within the nucleus.

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -Immunosuppressive therapy with the drugs cyclosporine and FK506 inhibits T cell activation by blocking the protein phosphatase activity of this molecule.

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -This molecule becomes an active transcription factor on dephosphorylation.

Which one of the following statements about MHC-TCR interactions is NOT true?

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -Binding of this molecule to Jun is needed for transcriptional activation of the IL-2 gene.

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -This molecule has the same downstream effect as addition of the drug phorbol myristate acetate (PMA) to T cells.

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -This protein is a well-characterized proto-oncogene product that on mutation to a constitutively active form has been associated with multiple neoplasms.

For each of the descriptions in questions , choose the T cell signaling molecule that best matches it from the list below (A-O). -This molecule binds to a receptor on the endoplasmic reticulum and stimulates release of calcium into the cytosol.

All of the following protein-protein interactions are involved in activation of naive helper T cells by antigen-presenting cells (APCs) EXCEPT binding of: