Exam 3: Antigen Processing and Presentation to T Lymphocytes

Many vaccines now in development will include highly purified, recombinant, or synthetic peptide antigens. These vaccine antigens are expected to stimulate highly specific immune responses, but they are less immunogenic than vaccines containing intact killed or live microbes. Adjuvants are substances added to such vaccines to enhance their ability to elicit T cell immune responses. Which of the following statements about adjuvants is NOT correct?

A helper T cell response to a protein antigen requires the participation of antigen-presenting cells that express which of the following types of molecules?

Antigen-presenting cells (APCs) perform which of the following functions in adaptive immune responses?

Match the description in questions with the lettered item (A-I) related to antigen-presentation pathways. -Required for proteolytic generation of class I MHC-binding peptides

Match the description in questions with the lettered item (A-I) related to antigen-presentation pathways. -The molecule that binds to the final product of the class II antigen-presenting pathway

Match the description in questions with the lettered item (A-I) related to antigen-presentation pathways. -Site of peptide loading of class I MHC molecules

The cell type shown below is found between follicles in lymph nodes and expresses B₇-1, B₇-2, and class II MHC. What type of cell is this?

A child who suffers from a persistent viral infection is found to have a deficiency in lymphocyte production and very few T and B cells. Other bone marrow-derived cells are produced in normal numbers, and MHC molecule expression on cells appears normal. Transfusion of mature T cells from an unrelated donor who had recovered from a previous infection by the same virus would not be expected to help the child clear his infection. Which one of the following is a reasonable explanation for why this therapeutic approach would fail?

Match the description in questions with the lettered item (A-I) related to antigen-presentation pathways. -Site of peptide loading of class II MHC molecules

Match the description in questions with the lettered item (A-I) related to antigen-presentation pathways. -Site of proteolysis of antigens in the class II MHC pathway