Exam 8: Congenital and Acquired Immunodeficiencies

Matching Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in B cell maturation at the pre-B cell stage caused by mutations in the gene encoding the B cell tyrosine kinase (Btk), resulting in undetectable levels of serum Ig

Match the descriptions in questions with the associated HIV gene (A-G). -Late gene product; encodes reverse transcriptase, integrase, protease

Matching Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in lymphocyte activation due to mutations in the gene encoding the SAP adapter protein required for inhibition of signaling by the SLAM molecule. Lack of SAP results in uncontrolled B cell proliferation, hypogammaglobulinemia, and B cell lymphoma in the setting of Epstein-Barr virus (EBV) infection.

All of the following may result in an acquired immunodeficiency EXCEPT:

Matching Match each of the following descriptions in questions with the appropriate disease (A-G). -Impaired CD4+ T cell development and activation due to lack of class II MHC expression, resulting in defective cell-mediated immunity and impaired T cell-dependent humoral immunity

Match the descriptions in questions with the associated HIV gene (A-G). -Late gene product; encodes nucleocapsid core and matrix proteins

A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses, as described in question 3, is called:

Which one of the following is typically NOT associated with T cell immunodeficiencies?

Match the descriptions in questions with the associated HIV gene (A-G). -Early gene product; required for elongation of viral transcripts

Matching Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in leukocyte adhesion-dependent functions, resulting from mutations in the gene encoding the CD18 integrin β chain, and leading to recurrent bacterial and fungal infections

In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH) response to a Candida antigen skin challenge?

Match the descriptions in questions with the associated HIV gene (A-G). -Late gene product; encodes coat proteins gp120 and gp41

Matching Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in phagocyte microbicidal activity as a result of defective production of reactive oxygen intermediates, most commonly from a mutation in the gene encoding cytochrome b558