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Exam 17: Lymphocyte Maturation and Expression of Antigen Receptor Genes

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Exam 1: Activation of T Lymphocytes10 Questionsadd course
Exam 2: Antibodies and Antigens10 Questionsadd course
Exam 3: Antigen Processing and Presentation to T Lymphocytes10 Questionsadd course
Exam 4: Antigen Receptors and Accessory Molecules of T Lymphocytes14 Questionsadd course
Exam 5: B Cell Activation and Antibody Production11 Questionsadd course
Exam 6: Effector Mechanisms of Cell-Mediated Immunity10 Questionsadd course
Exam 7: Cells and Tissues of the Immune System10 Questionsadd course
Exam 8: Congenital and Acquired Immunodeficiencies13 Questionsadd course
Exam 9: Cytokines14 Questionsadd course
Exam 10: Diseases Caused by Immune Responses: Hypersensitivity and Autoimmunity10 Questionsadd course
Exam 11: General Properties of Immune Response6 Questionsadd course
Exam 12: The Major Histocompatibility Complex9 Questionsadd course
Exam 13: Effector Mechanisms of Humoral Immunity10 Questionsadd course
Exam 14: Immediate Hypersensitivity10 Questionsadd course
Exam 15: Innate Immunity12 Questionsadd course
Exam 16: Immunologic Tolerance10 Questionsadd course
Exam 17: Lymphocyte Maturation and Expression of Antigen Receptor Genes11 Questionsadd course
Exam 18: Immunity to Microbes10 Questionsadd course
Exam 19: Transplantation Immunology10 Questionsadd course
Exam 20: Immunity to Tumors14 Questionsadd course
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The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . -Encodes the isotype of antibodies made by naive B cells -Encodes the isotype of antibodies made by naive B cells

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Question 1
Correct Answer:
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D
Naive B cells produce IgM and IgD antibody isotypes
The IgM isotype is a characteristic of the heavy chain constant region, encoded by the Cm gene segment.

Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?

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Question 2
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A

Matching The block in the stage of lymphocyte development described in questions , will be caused by a mutation in which of the genes listed (A-F)? -Stem cell to committed B or T lineage precursor

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Question 3
Correct Answer:
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B

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . -Homologous segments of this type of gene segment that encode part of the third complementarity determining region (CDR3) of Ig heavy chains and TCR b chains but not Ig light chains or TCR a chains -Homologous segments of this type of gene segment that encode part of the third complementarity determining region (CDR3) of Ig heavy chains and TCR b chains but not Ig light chains or TCR a chains

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Question 4

Which of the following statements about negative selection during lymphocyte development is most accurate?

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Question 5

Matching The block in the stage of lymphocyte development described in questions , will be caused by a mutation in which of the genes listed (A-F)? -Pro-B cell to pre-B cell

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Question 6

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . -A segment that encodes Ig-like domains that form part of the antigen-binding region of an Ig molecule -A segment that encodes Ig-like domains that form part of the antigen-binding region of an Ig molecule

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Question 7

Which of the following is NOT a required step in B and T lymphocyte maturation?

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Question 8

Matching The block in the stage of lymphocyte development described in questions , will be caused by a mutation in which of the genes listed (A-F)? -CD4+CD8+ thymocyte to single positive CD8+ thymocyte

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Question 9

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14. Choose the lettered label on the figure (A-E) that best matches the description in questions . -A type of gene segment involved in somatic recombination events in Ig heavy chain and light chain as well as TCR a and b chain gene loci -A type of gene segment involved in somatic recombination events in Ig heavy chain and light chain as well as TCR a and b chain gene loci

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Question 10

Which of the following is NOT a property of the V(D)J recombinase?

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Question 11
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