Question 1

In phase 1 metabolism, ethanol is converted to acetaldehyde by what enzyme?

Accepted Answer

A)  CYP450 
B)  alcohol oxidase 
C)  alcohol dehydrogenase 
D)  aldehyde deoxidase 
E)  none of the above 
A)  CYP450 
B)  alcohol oxidase 
C)  alcohol dehydrogenase 
D)  aldehyde deoxidase 
E)  none of the above C

Question 2

Given the following data:
R/Vd = 0.70L/kg (men) 0.60L/kg (women)
Beta = 0.02 g/dL per hour
Standard drink = 14g
Calculate the BACmax (g/dL) for a man (100kg) who drinks two shots of tequila and ingests 29 g of ethanol

Accepted Answer

A)  0.07 
B)  0.04 
C)  0.68 
D)  0.4 
E)  none of the above 
A)  0.07 
B)  0.04 
C)  0.68 
D)  0.4 
E)  none of the above B

Question 3

A pint (16 fluid ounces) of a strong beer (9.3% alcohol) is the equivalent of how many standard drinks? The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams.

Accepted Answer

A)  2.7 
B)  1.5 
C)  1 
D)  3 
E)  none of the above 
A)  2.7 
B)  1.5 
C)  1 
D)  3 
E)  none of the above A

Question 4

Phenytoin is a weakly acidic drug with a pKa of 8.3. Assume that the urine has a pH of 6.2. To what degree will phenytoin be ion trapped in the urine?

Accepted Answer

A)  extensive ion trapping 
B)  moderate ion trapping 
C)  no ion trapping 
D)  insufficient data provided 
E)  none of the above 
A)  extensive ion trapping 
B)  moderate ion trapping 
C)  no ion trapping 
D)  insufficient data provided 
E)  none of the above

Question 5

The novel basic drug methcathinone has a pKa of 8. OF is collected from a driver stopped for possible DUI and is tested in a forensic toxicology laboratory. Assuming the blood is at physiological pH and the OF has a pH of 6.5, the concentration detected in the OF is likely to be _________ than the plasma concentration.

Accepted Answer

A)  less than 
B)  essentially the same 
C)  higher 
D)  much less 
E)  none of the above 
A)  less than 
B)  essentially the same 
C)  higher 
D)  much less 
E)  none of the above

Question 6

Why is vitreous fluid considered to be valuable as a matrix in post-mortem testing?

Accepted Answer

A)  There is plenty of it to work with 
B)  concentrations of drugs and metabolites are preserved longer than in other tissues 
C)  It concentrates the lipophilic drugs and metabolites 
D)  It decomposes into simple components 
E)  none of the above 
A)  There is plenty of it to work with 
B)  concentrations of drugs and metabolites are preserved longer than in other tissues 
C)  It concentrates the lipophilic drugs and metabolites 
D)  It decomposes into simple components 
E)  none of the above

Question 7

Immunoassays are used for what purpose in forensic toxicology?

Accepted Answer

A)  identification of NPSs 
B)  screening for selected drug classes 
C)  screening for new variants of opioids 
D)  quantifying opioids 
E)  none of the above 
A)  identification of NPSs 
B)  screening for selected drug classes 
C)  screening for new variants of opioids 
D)  quantifying opioids 
E)  none of the above

Question 8

The central blood collected at autopsy comes from the

Accepted Answer

A)  stomach 
B)  liver 
C)  heart 
D)  femoral artery 
E)  none of the above 
A)  stomach 
B)  liver 
C)  heart 
D)  femoral artery 
E)  none of the above

Question 9

The femoral artery/vein is the place that ________ blood is collected at autopsy

Accepted Answer

A)  central 
B)  peripheral 
C)  redistributed 
D)  separated 
E)  none of the above 
A)  central 
B)  peripheral 
C)  redistributed 
D)  separated 
E)  none of the above

Question 10

Which body fluids are considered filtrates of the blood?

Accepted Answer

A)  oral fluid and urine 
B)  urine and bile 
C)  bile and oral fluid 
D)  vitreous fluid and urine 
E)  none of the above 
A)  oral fluid and urine 
B)  urine and bile 
C)  bile and oral fluid 
D)  vitreous fluid and urine 
E)  none of the above

Question 11

Anabolic agent steroids (AAS) compounds are used in sports because

Accepted Answer

A)  the increase the red blood cell count 
B)  they improve the oxygen capacity of hemoglobin 
C)  they provide a long-term enhancement of adrenaline capacity 
D)  they promote development of male characteristics 
E)  none of the above 
A)  the increase the red blood cell count 
B)  they improve the oxygen capacity of hemoglobin 
C)  they provide a long-term enhancement of adrenaline capacity 
D)  they promote development of male characteristics 
E)  none of the above

Question 12

What type of reactions are utilized in immunoassay tests?

Accepted Answer

A)  acid-base 
B)  oxidation-reduction 
C)  antigen-antibody 
D)  enzyme-substrate 
E)  none of the above 
A)  acid-base 
B)  oxidation-reduction 
C)  antigen-antibody 
D)  enzyme-substrate 
E)  none of the above

Question 13

An analyst collects hair from a victim of a drug faciliated sexual assault. After cleaning, they cut it into 0.5cm segments and analyze these segments and find flunitrazepam at measurable concentrations. When the data is plotted as drug concentration on the y-axis and concentration on the x-axis, the points form a roughly linear pattern sloping downward. The indicates that

Accepted Answer

A)  the dose was relatively recent 
B)  the dose was several days or weeks in the past 
C)  the dose has not yet undergone metabolism 
D)  the drug does not metabolize 
E)  none of the above 
A)  the dose was relatively recent 
B)  the dose was several days or weeks in the past 
C)  the dose has not yet undergone metabolism 
D)  the drug does not metabolize 
E)  none of the above

Question 14

Which of these fluids is considered to be anatomically isolated?

Accepted Answer

A)  oral fluid 
B)  bile 
C)  urine 
D)  vitreous fluid 
E)  none of the above 
A)  oral fluid 
B)  bile 
C)  urine 
D)  vitreous fluid 
E)  none of the above

Question 15

Given the following data:
R/Vd = 0.70L/kg (men) 0.60L/kg (women)
Beta = 0.02 g/dL per hour
Standard drink = 14g
Estimate the number of standard drinks consumed by a woman (75kg) whose BACmax is the legal limit of 0.08g/dL

Accepted Answer

A)  less than one 
B)  2.6 
C)  3.0 
D)  1.3 
E)  none of the above 
A)  less than one 
B)  2.6 
C)  3.0 
D)  1.3 
E)  none of the above

Question 16

The limits established for BAC are set by

Accepted Answer

A)  public health services 
B)  law enforcement 
C)  legislation 
D)  local data 
E)  none of the above 
A)  public health services 
B)  law enforcement 
C)  legislation 
D)  local data 
E)  none of the above

Question 17

A man downs two shots (1.5 fluid ounces each) of a liquor that is listed as 72 proof. The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams. How many grams of ethanol did he ingest?

Accepted Answer

A)  75 
B)  14 
C)  35 
D)  27 
E)  none of the above 
A)  75 
B)  14 
C)  35 
D)  27 
E)  none of the above

Question 18

The descriptor rho used in blood alcohol calculations is the same as the

Accepted Answer

A)  logP 
B)  pKa 
C)  Vd 
D)  bioavailability F 
E)  none of the above 
A)  logP 
B)  pKa 
C)  Vd 
D)  bioavailability F 
E)  none of the above

Question 19

A woman drinks a large glass of wine (11.0 fluid ounces) that is listed as 13% alcohol. The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams. How many grams of ethanol did she ingest?

Accepted Answer

A)  312 
B)  36 
C)  3 
D)  46 
E)  none of the above 
A)  312 
B)  36 
C)  3 
D)  46 
E)  none of the above

Question 20

According to Henry's Law, the concentration of ethanol in the blood is about _____ times that in exhaled air

Accepted Answer

A)  100 
B)  2100 
C)  1000 
D)  1500 
E)  none of the above 
A)  100 
B)  2100 
C)  1000 
D)  1500 
E)  none of the above

In phase 1 metabolism, ethanol is converted to acetaldehyde by what enzyme?

Given the following data: R/V_d = 0.70L/kg (men) 0.60L/kg (women) Beta = 0.02 g/dL per hour Standard drink = 14g Calculate the BACmax (g/dL) for a man (100kg) who drinks two shots of tequila and ingests 29 g of ethanol

A pint (16 fluid ounces) of a strong beer (9.3% alcohol) is the equivalent of how many standard drinks? The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams.

Phenytoin is a weakly acidic drug with a pKa of 8.3. Assume that the urine has a pH of 6.2. To what degree will phenytoin be ion trapped in the urine?

Why is vitreous fluid considered to be valuable as a matrix in post-mortem testing?

Immunoassays are used for what purpose in forensic toxicology?

The central blood collected at autopsy comes from the

The femoral artery/vein is the place that ________ blood is collected at autopsy

Which body fluids are considered filtrates of the blood?

Anabolic agent steroids (AAS) compounds are used in sports because

What type of reactions are utilized in immunoassay tests?

Which of these fluids is considered to be anatomically isolated?

Given the following data: R/V_d = 0.70L/kg (men) 0.60L/kg (women) Beta = 0.02 g/dL per hour Standard drink = 14g Estimate the number of standard drinks consumed by a woman (75kg) whose BAC_max is the legal limit of 0.08g/dL

The limits established for BAC are set by

A man downs two shots (1.5 fluid ounces each) of a liquor that is listed as 72 proof. The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams. How many grams of ethanol did he ingest?

The descriptor rho used in blood alcohol calculations is the same as the

A woman drinks a large glass of wine (11.0 fluid ounces) that is listed as 13% alcohol. The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams. How many grams of ethanol did she ingest?

According to Henry's Law, the concentration of ethanol in the blood is about _____ times that in exhaled air

Making Good Measurements

Assuring Good Measurements

Chemical Fundamentals

Chromatography and Mass Spectrometry

Spectroscopy

Overview of Drug Analysis

Novel Psychoactive Substances

Fundamentals of Toxicology

Overview of Combustion Chemistry

Fire Investigation and Fire Debris Analysis

Explosives

Firearms and Firearms Discharge Residue

Forensic Chemistry and Trace Evidence Analysis

Filters

Exam 9: Applications of Forensic Toxicology

In phase 1 metabolism, ethanol is converted to acetaldehyde by what enzyme?

Given the following data: R/Vd = 0.70L/kg (men) 0.60L/kg (women) Beta = 0.02 g/dL per hour Standard drink = 14g Calculate the BACmax (g/dL) for a man (100kg) who drinks two shots of tequila and ingests 29 g of ethanol

A pint (16 fluid ounces) of a strong beer (9.3% alcohol) is the equivalent of how many standard drinks? The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams.

Phenytoin is a weakly acidic drug with a pKa of 8.3. Assume that the urine has a pH of 6.2. To what degree will phenytoin be ion trapped in the urine?

Why is vitreous fluid considered to be valuable as a matrix in post-mortem testing?

Immunoassays are used for what purpose in forensic toxicology?

The central blood collected at autopsy comes from the

The femoral artery/vein is the place that ________ blood is collected at autopsy

Which body fluids are considered filtrates of the blood?

Anabolic agent steroids (AAS) compounds are used in sports because

What type of reactions are utilized in immunoassay tests?

Which of these fluids is considered to be anatomically isolated?

Given the following data: R/Vd = 0.70L/kg (men) 0.60L/kg (women) Beta = 0.02 g/dL per hour Standard drink = 14g Estimate the number of standard drinks consumed by a woman (75kg) whose BACmax is the legal limit of 0.08g/dL

The limits established for BAC are set by

A man downs two shots (1.5 fluid ounces each) of a liquor that is listed as 72 proof. The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams. How many grams of ethanol did he ingest?

The descriptor rho used in blood alcohol calculations is the same as the

A woman drinks a large glass of wine (11.0 fluid ounces) that is listed as 13% alcohol. The density of ethanol is 0.88 ounces per fluid ounce and one ounce is 28.35 grams. How many grams of ethanol did she ingest?

According to Henry's Law, the concentration of ethanol in the blood is about _____ times that in exhaled air

Making Good Measurements

Assuring Good Measurements

Chemical Fundamentals

Chromatography and Mass Spectrometry

Spectroscopy

Overview of Drug Analysis

Novel Psychoactive Substances

Fundamentals of Toxicology

Overview of Combustion Chemistry

Fire Investigation and Fire Debris Analysis

Explosives

Firearms and Firearms Discharge Residue

Forensic Chemistry and Trace Evidence Analysis

Filters

Given the following data: R/V_d = 0.70L/kg (men) 0.60L/kg (women) Beta = 0.02 g/dL per hour Standard drink = 14g Calculate the BACmax (g/dL) for a man (100kg) who drinks two shots of tequila and ingests 29 g of ethanol

Given the following data: R/V_d = 0.70L/kg (men) 0.60L/kg (women) Beta = 0.02 g/dL per hour Standard drink = 14g Estimate the number of standard drinks consumed by a woman (75kg) whose BAC_max is the legal limit of 0.08g/dL