Question 1

Show where the 2′-OH group is located on the NTP below. What role does the 2′-OH play in a hammerhead ribozyme?
‪

Accepted Answer

The answer of Show where the 2′-OH group is located...

Question 2

Compare and contrast small ribozymes and large ribozymes.

Accepted Answer

Similarities: Both are RNA catalysts, an

Question 3

Which statement about a pseudoknot motif is not true?

Accepted Answer

A)  Pseudoknot motifs have only been characterized in plant RNA viruses. 
B)  A highly conserved pseudoknot is required for telomerase activity. 
C)  Coaxial stacking of base-paired stems forms a quasicontinuous double helix. 
D)  A single-stranded loop base pairs with a complementary sequence outside this loop. 
A)  Pseudoknot motifs have only been characterized in plant RNA viruses. 
B)  A highly conserved pseudoknot is required for telomerase activity. 
C)  Coaxial stacking of base-paired stems forms a quasicontinuous double helix. 
D)  A single-stranded loop base pairs with a complementary sequence outside this loop.

Question 4

Which of the following is not a critical cellular role for non-coding RNAs?

Accepted Answer

A)  mRNA splicing 
B)  Ribosome function 
C)  DNA replication 
D)  Regulation of gene expression 
A)  mRNA splicing 
B)  Ribosome function 
C)  DNA replication 
D)  Regulation of gene expression

Question 5

Which statement is true?

Accepted Answer

A)  All proteins are enzymes. 
B)  All proteins are enzymes, and some RNA molecules also are catalytic. 
C)  All enzymes are proteins. 
D)  Most enzymes are proteins, but some RNA molecules also are catalytic. 
A)  All proteins are enzymes. 
B)  All proteins are enzymes, and some RNA molecules also are catalytic. 
C)  All enzymes are proteins. 
D)  Most enzymes are proteins, but some RNA molecules also are catalytic.

Question 6

A retrovirus, such as HIV-1,

Accepted Answer

A)  uses non-coding RNAs to package its genome into a capsid 
B)  stores its genome as an RNA sequence 
C)  uses host cell ribozymes to process its genome 
D)  converts its DNA genome to an RNA once inside the host cell 
A)  uses non-coding RNAs to package its genome into a capsid 
B)  stores its genome as an RNA sequence 
C)  uses host cell ribozymes to process its genome 
D)  converts its DNA genome to an RNA once inside the host cell

Question 7

Give an example of a common noncanonical base pair in RNA and discuss the functional significance of this type of base pair.

Accepted Answer

A common noncanonical base pair in RNA i

Question 8

Give an example of a common base modification in RNA and discuss the functional significance of base modifications.

Accepted Answer

One common base modification in RNA is t

Question 9

A particular RNA chain

Accepted Answer

A)  always folds into the same secondary structure. 
B)  can fold into many different secondary structures and still be functional. 
C)  can misfold into different secondary structures by incorrect base-pairing, but will stillalways form the same tertiary structure. 
D)  can misfold and become trapped in a misfolded structure in the absence of RNAchaperones. 
A)  always folds into the same secondary structure. 
B)  can fold into many different secondary structures and still be functional. 
C)  can misfold into different secondary structures by incorrect base-pairing, but will stillalways form the same tertiary structure. 
D)  can misfold and become trapped in a misfolded structure in the absence of RNAchaperones.

Question 10

You have discovered an RNA that you think is a self-splicing ribozyme. You also have evidence that it requires a pseudoknot for catalytic activity. Briefly outline an experiment you could perform to test these two hypotheses.

Accepted Answer

To test the hypothesis that the RNA is a

Question 11

Subviral RNA particles such as viroids and satellite RNAs differ from viruses in that

Accepted Answer

A)  subviral RNA particles usually do not encode proteins 
B)  subviral RNA particles can only infect plant cells 
C)  subviral RNA particles usually do not cause disease 
D)  the infectious form of subviral RNA particles are usually encased by proteins 
A)  subviral RNA particles usually do not encode proteins 
B)  subviral RNA particles can only infect plant cells 
C)  subviral RNA particles usually do not cause disease 
D)  the infectious form of subviral RNA particles are usually encased by proteins

Question 12

Make up an RNA sequence that will form a hairpin with a 9 bp stem and a 7 bp loop. Draw both the primary structure and the secondary structure.

Accepted Answer

One of the many possible seque

Question 13

Hairpin loops, base-paired stems, and bulges make up what part of RNA's structure?

Accepted Answer

A)  primary 
B)  secondary 
C)  tertiary 
D)  quaternary 
A)  primary 
B)  secondary 
C)  tertiary 
D)  quaternary

Question 14

Which of the following is not an example of a tertiary RNA structure?

Accepted Answer

A)  tetraloop 
B)  kink-turn 
C)  base-paired stem 
D)  ribose zipper 
A)  tetraloop 
B)  kink-turn 
C)  base-paired stem 
D)  ribose zipper

Question 15

There is a tremendous versatility of functional RNA products involved in a wide range of
Cellular processes. One of the key contributing factors to this versatility is

Accepted Answer

A)  the ability of RNA to form unique 3D structures that act similarly to proteins 
B)  the ability of RNA to cleave phosphodiester bonds in other nucleic acids 
C)  the ability of RNA to be copied into DNA 
D)  the ability of RNA to serve as a messenger during protein synthesis 
A)  the ability of RNA to form unique 3D structures that act similarly to proteins 
B)  the ability of RNA to cleave phosphodiester bonds in other nucleic acids 
C)  the ability of RNA to be copied into DNA 
D)  the ability of RNA to serve as a messenger during protein synthesis

Question 16

You are characterizing a novel ribozyme. Describe an experiment to analyze the folding kinetics of the ribozyme.

Accepted Answer

To analyze the folding kinetics of the n

Question 17

Many ribozymes

Accepted Answer

A)  are autocatalytic 
B)  are metalloenzymes 
C)  cleave phosphodiester bonds 
D)  all of the above 
A)  are autocatalytic 
B)  are metalloenzymes 
C)  cleave phosphodiester bonds 
D)  all of the above

Question 18

Which of the following statements about tRNA is not true?

Accepted Answer

A)  In general, tRNAs contain more than 50 modified bases, such as pseudouridine. 
B)  tRNA loops each have a separate function. 
C)  Base-paired stems are often involved in long-range interactions with other stems bycoaxial stacking. 
D)  The three-dimensional structure of tRNA is referred to as a "cloverleaf." 
A)  In general, tRNAs contain more than 50 modified bases, such as pseudouridine. 
B)  tRNA loops each have a separate function. 
C)  Base-paired stems are often involved in long-range interactions with other stems bycoaxial stacking. 
D)  The three-dimensional structure of tRNA is referred to as a "cloverleaf."

Question 19

The term ribozyme describes what property of RNA molecules?

Accepted Answer

A)  they are single-stranded 
B)  they can be catalytic 
C)  their shape 
D)  the formation of hairpin loops 
A)  they are single-stranded 
B)  they can be catalytic 
C)  their shape 
D)  the formation of hairpin loops

Show where the 2′-OH group is located on the NTP below. What role does the 2′-OH play in a hammerhead ribozyme? ‪

Compare and contrast small ribozymes and large ribozymes.

Which statement about a pseudoknot motif is not true?

Which of the following is not a critical cellular role for non-coding RNAs?

Which statement is true?

A retrovirus, such as HIV-1,

Give an example of a common noncanonical base pair in RNA and discuss the functional significance of this type of base pair.

Give an example of a common base modification in RNA and discuss the functional significance of base modifications.

A particular RNA chain

You have discovered an RNA that you think is a self-splicing ribozyme. You also have evidence that it requires a pseudoknot for catalytic activity. Briefly outline an experiment you could perform to test these two hypotheses.

Subviral RNA particles such as viroids and satellite RNAs differ from viruses in that

Make up an RNA sequence that will form a hairpin with a 9 bp stem and a 7 bp loop. Draw both the primary structure and the secondary structure.

Hairpin loops, base-paired stems, and bulges make up what part of RNA's structure?

Which of the following is not an example of a tertiary RNA structure?

There is a tremendous versatility of functional RNA products involved in a wide range of Cellular processes. One of the key contributing factors to this versatility is

You are characterizing a novel ribozyme. Describe an experiment to analyze the folding kinetics of the ribozyme.

Many ribozymes

Which of the following statements about tRNA is not true?

The term ribozyme describes what property of RNA molecules?

The Beginnings of Molecular Biology

The Structure of DNA

Protein Structure and Folding

Genome Organization and Evolution

DNA Replication and Telomere Maintenance

DNA Repair Pathways

Recombinant Dna Technology and Molecular Cloning

Tools for Analyzing Gene Expression

Transcription in Bacteria

Transcription in Eukaryotes

Epigenetic Mechanisms of Gene Regulation

RNA Processing and Post-Transcriptional Gene Regulation

The Mechanism of Translation

Genetically Modified Organisms: Use in Basic and Applied Research

Genome Analysis: DNA Typing, Genomics, and Beyond

Medical Molecular Biology

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Exam 3: The Versatility of RNA

Show where the 2′-OH group is located on the NTP below. What role does the 2′-OH play in a hammerhead ribozyme? ‪

Compare and contrast small ribozymes and large ribozymes.

Which statement about a pseudoknot motif is not true?

Which of the following is not a critical cellular role for non-coding RNAs?

Which statement is true?

A retrovirus, such as HIV-1,

Give an example of a common noncanonical base pair in RNA and discuss the functional significance of this type of base pair.

Give an example of a common base modification in RNA and discuss the functional significance of base modifications.

A particular RNA chain

You have discovered an RNA that you think is a self-splicing ribozyme. You also have evidence that it requires a pseudoknot for catalytic activity. Briefly outline an experiment you could perform to test these two hypotheses.

Subviral RNA particles such as viroids and satellite RNAs differ from viruses in that

Make up an RNA sequence that will form a hairpin with a 9 bp stem and a 7 bp loop. Draw both the primary structure and the secondary structure.

Hairpin loops, base-paired stems, and bulges make up what part of RNA's structure?

Which of the following is not an example of a tertiary RNA structure?

There is a tremendous versatility of functional RNA products involved in a wide range of Cellular processes. One of the key contributing factors to this versatility is

You are characterizing a novel ribozyme. Describe an experiment to analyze the folding kinetics of the ribozyme.

Many ribozymes

Which of the following statements about tRNA is not true?

The term ribozyme describes what property of RNA molecules?

The Beginnings of Molecular Biology

The Structure of DNA

Protein Structure and Folding

Genome Organization and Evolution

DNA Replication and Telomere Maintenance

DNA Repair Pathways

Recombinant Dna Technology and Molecular Cloning

Tools for Analyzing Gene Expression

Transcription in Bacteria

Transcription in Eukaryotes

Epigenetic Mechanisms of Gene Regulation

RNA Processing and Post-Transcriptional Gene Regulation

The Mechanism of Translation

Genetically Modified Organisms: Use in Basic and Applied Research

Genome Analysis: DNA Typing, Genomics, and Beyond

Medical Molecular Biology

Filters