Question 1

Which of the following are responsible for Alzheimer's disease?

Accepted Answer

A) polyglutamine aggregates 
B) neurofibrillary tangles of polymeric microtubule-binding protein tau 
C) extracellular deposits of amyloid-b and intracellular neurofibrillary tangles of microtubule-binding protein tau 
D) mutations in the huntingtin gene 
A) polyglutamine aggregates 
B) neurofibrillary tangles of polymeric microtubule-binding protein tau 
C) extracellular deposits of amyloid-b and intracellular neurofibrillary tangles of microtubule-binding protein tau 
D) mutations in the huntingtin gene

Question 2

In which of the following macromolecular structures is protein degradation compartmentalized?

Accepted Answer

A) ribosomes and endoplasmic reticulum 
B) ribosomes and Golgi 
C) proteasomes and mitochondria 
D) proteasomes and lysosomes 
A) ribosomes and endoplasmic reticulum 
B) ribosomes and Golgi 
C) proteasomes and mitochondria 
D) proteasomes and lysosomes

Question 3

Which of the following are the primary driving forces for protein folding?

Accepted Answer

A) hydrogen bonds 
B) van der Waals interactions 
C) hydrophobic interactions 
D) electrostatic interactions 
A) hydrogen bonds 
B) van der Waals interactions 
C) hydrophobic interactions 
D) electrostatic interactions

Question 4

Which of the following is a part of the folding cycle in the GroES-GroEL complex of E.coli?

Accepted Answer

A) GroES promotes GTP hydrolysis,and a-subunits undergo a conformational change that buries the hydrophobic patches. 
B) GroES associates to the complex. 
C) Partially folded,protein hydrophilic residues bind GroEL. 
D) GroES is recruited to GroEL. 
A) GroES promotes GTP hydrolysis,and a-subunits undergo a conformational change that buries the hydrophobic patches. 
B) GroES associates to the complex. 
C) Partially folded,protein hydrophilic residues bind GroEL. 
D) GroES is recruited to GroEL.

Question 5

Which of the following is NOT a characteristic of the mammalian translocon?

Accepted Answer

A) It has Sec61 complex at the core. 
B) It is a transmembrane,protein-conducting channel. 
C) BiP carries out ATP-dependent protein folding. 
D) It is composed of a single transmembrane-spanning (TMS)protein. 
A) It has Sec61 complex at the core. 
B) It is a transmembrane,protein-conducting channel. 
C) BiP carries out ATP-dependent protein folding. 
D) It is composed of a single transmembrane-spanning (TMS)protein.

Question 6

Which of the following is NOT correct regarding the protein degradation process involving ubiquitin?

Accepted Answer

A) The modified protein is degraded by an ATP-dependent protease complex. 
B) The ubiquitin binding to the protein to be degraded leads to a novel branched protein. 
C) The ubiquitin is covalently attached to a cysteine residue in the protein to be degraded. 
D) Three additional proteins (E1,E2,and E3)are involved in the ligation of ubiquitin to the protein. 
A) The modified protein is degraded by an ATP-dependent protease complex. 
B) The ubiquitin binding to the protein to be degraded leads to a novel branched protein. 
C) The ubiquitin is covalently attached to a cysteine residue in the protein to be degraded. 
D) Three additional proteins (E1,E2,and E3)are involved in the ligation of ubiquitin to the protein.

Question 7

Which of the following is the most common form of posttranslational processing?

Accepted Answer

A) carbohydrate addition 
B) proteolytic cleavage 
C) lipid addition 
D) phosphorylation 
A) carbohydrate addition 
B) proteolytic cleavage 
C) lipid addition 
D) phosphorylation

Question 8

Which of the following describes the functional role of the 19S cap in proteasome?

Accepted Answer

A) disposal 
B) regulatory 
C) ubiquitination complex 
D) electron transport 
A) disposal 
B) regulatory 
C) ubiquitination complex 
D) electron transport

Exam 32: Completing the Protein Life Cycle: Folding, processing, and Degradation

Which of the following are responsible for Alzheimer's disease?

In which of the following macromolecular structures is protein degradation compartmentalized?

Which of the following are the primary driving forces for protein folding?

Which of the following is a part of the folding cycle in the GroES-GroEL complex of E.coli?

Which of the following is NOT a characteristic of the mammalian translocon?

Which of the following is NOT correct regarding the protein degradation process involving ubiquitin?

Which of the following is the most common form of posttranslational processing?

Which of the following describes the functional role of the 19S cap in proteasome?

The Facts of Life: Chemistry Is the Logic of Biological Phenomena

Water: the Medium of Life

Thermodynamics of Biological Systems

Amino Acids

Proteins: Their Primary Structure and Biological Functions

Proteins: Secondary, tertiary, and Quaternary Structure

Carbohydrates and the Glycoconjugates of Cell Surfaces

Lipids

Lipid Biosynthesis

Membranes and Membrane Transport

The Reception and Transmission of Extracellular Information

Enzymes Kinetics and Specificity

Mechanisms of Enzyme Action

Enzyme Regulation

Molecular Motors

Nutrition and the Organization of Metabolism

Glycolysis

The Tricarboxylic Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Gluconeogenesis, glycogen Metabolism, and the Pentose Phosphate Pathway

Fatty Acid Catabolism

Nitrogen Acquisition and Amino Acid Metabolism

Nucleotides and Nucleic Acids

Structure of Nucleic Acids

Synthesis and Degradation of Nucleotides

Recombinant Dna: Cloning and Creation of Chimeric Genes

DNA Metabolism: Replication, recombination, and Repair

Transcription and the Regulation of Gene Expression

Protein Synthesis

Post-Transcriptional Regulation of Gene Expression

Metabolic Integration and Organ Specialization

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