Exam 1: Pathology

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Increased generation of oxygen free radicals from parenchymal and endothelial cells and from infiltrating leukocytes would cause damage in which of the following cell injury mechanisms?

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Which of the following would NOT cause mitochondrial damage?

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Some energy producing processes produce reactive oxygen species (free radicals) that can cause damage to cells. Which of the following is NOT a mechanism of free Radical generation?

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Which of the following is NOT involved in free radical neutralization?

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Which of the following describes hyperplasia?

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Cytokine activation of endothelium (with neutrophils) involves which of the following?

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Acute and Chronic Inflammation -Acute inflammation may be triggered by infections, trauma, physical or chemical agents, tissue necrosis, foreign bodies, and immune reactions. Which of the following is NOT seen in acute inflammation?

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Which of the following is associated with cachexia, seen in patients with chronic Inflammatory diseases and cancer?

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Match the endothelial molecule (leukocyte adhesion molecule) with its major role: -Rolling (neutrophils, monocytes, lymphocytes)

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Which of the following is NOT a mechanism by which free radicals cause cell injury?

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Match the abnormality which results in intracellular accumulations in nonneoplatics cells with the resultant disease: -Deficiencies in critical enzymes

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Match the cellular response normally seen in cells with the stimuli (description): -Reduced oxygen supply, chemical injury, infection

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CCl4 is converted by P-450 to which highly reactive toxic free radical?

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Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other -Leukocytes, mast cells + +, broncoconstrict, leukocyte prime

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Depletion of ATP to <5% to 10% of normal levels has widespread effects on many critical cellular systems. Which of the following is NOT a condition which may lead to Depletion of ATP?

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Which of the following is NOT a principle relevant to most forms of cell injury?

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When blood flow is restored to cells that have been previously made ischemic but have not died, injury is often exacerbated and proceeds at an accelerated pace.

(True/False)
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Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other -Macrophages, other -+ , acute-phase reactions

(Multiple Choice)
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Nitric oxide (NO) is synthesized from what amino acid by the enzyme nitric oxide synthase (NOS) ?

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Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other -Leukocytes +-, endothelial damage, tissue damage

(Multiple Choice)
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