Question 1

In glycoproteins, the terminal position in the oligosaccharide is most commonly occupied by:

Accepted Answer

A) N-acetylglucosamine. 
B) Glucose. 
C) Mannose. 
D) Iduronic acid. 
E) N-acetylneuraminic acid. 
A) N-acetylglucosamine. 
B) Glucose. 
C) Mannose. 
D) Iduronic acid. 
E) N-acetylneuraminic acid. E

Question 2

Misfolded proteins accumulate in some age-related degenerative diseases.Normally, however, misfolded proteins are escorted to the proteosome for destruction.This process begins with the covalent attachment of the protein:

Accepted Answer

A) Ubiquitin. 
B) Adaptin. 
C) Clathrin. 
D) Tubulin. 
E) Dolichol. 
A) Ubiquitin. 
B) Adaptin. 
C) Clathrin. 
D) Tubulin. 
E) Dolichol. A

Question 3

The most promising gene therapy strategy for I-cell disease is to:

Accepted Answer

A) Introduce an intact copy of the a-L-iduronidase gene. 
B) Replace a normal copy of the iduronate sulfatase gene with one containing a nuclear localization signal. 
C) Replace the N-acetyl-galactosamine transferase gene with one containing a lysosomal localization signal. 
D) Replace a faulty copy of the mannose-6-phosphate transferase gene with a functional copy. 
E) Replace all lysosomal enzyme genes. 
A) Introduce an intact copy of the a-L-iduronidase gene. 
B) Replace a normal copy of the iduronate sulfatase gene with one containing a nuclear localization signal. 
C) Replace the N-acetyl-galactosamine transferase gene with one containing a lysosomal localization signal. 
D) Replace a faulty copy of the mannose-6-phosphate transferase gene with a functional copy. 
E) Replace all lysosomal enzyme genes. D

Question 4

The first step in the post-translational processing of secreted proteins in eukaryotes is:

Accepted Answer

A) Proteolytic removal of the first two or three amino acid residues from the amino terminus by the signal recognition particle. 
B) Attachment of a mannose-rich oligopeptide to asparagine side chains. 
C) Attachment of mannose-6-phosphate to the protein. 
D) Proteolytic cleavage by signal peptidase. 
E) Formation of disulfide bonds. 
A) Proteolytic removal of the first two or three amino acid residues from the amino terminus by the signal recognition particle. 
B) Attachment of a mannose-rich oligopeptide to asparagine side chains. 
C) Attachment of mannose-6-phosphate to the protein. 
D) Proteolytic cleavage by signal peptidase. 
E) Formation of disulfide bonds.

In glycoproteins, the terminal position in the oligosaccharide is most commonly occupied by:

Misfolded proteins accumulate in some age-related degenerative diseases.Normally, however, misfolded proteins are escorted to the proteosome for destruction.This process begins with the covalent attachment of the protein:

The most promising gene therapy strategy for I-cell disease is to:

The first step in the post-translational processing of secreted proteins in eukaryotes is:

Introduction to Biomolecules

Introduction to Protein Structure

Oxygen Transporters: Hemoglobin and Myoglobin

Enzymatic Reactions

Coenzymes

DNA, RNA, and Protein Synthesis

The Human Genome

Introduction to Genetic Diseases

Viruses

DNA Technology

Biological Membranes

The Cytoskeleton

The Extracellular Matrix

Plasma Proteins

Extracellular Messengers

Intracellular Messengers

Cellular Growth Control and Cancer

Digestive Enzymes

Introduction to Metabolic Pathways

Glycolysis, Tricarboxylic Acid Cycle, and Oxidative Phosphorylation

Carbohydrate Metabolism

The Metabolism of Fatty Acids and Triglycerides

The Metabolism of Membrane Lipids

Lipid Transport

Amino Acid Metabolism

Heme Metabolism

The Metabolism of Purines and Pyrimidines

Vitamins and Minerals

Integration of Metabolism

Filters

Exam 8: Protein Targeting

In glycoproteins, the terminal position in the oligosaccharide is most commonly occupied by:

Misfolded proteins accumulate in some age-related degenerative diseases.Normally, however, misfolded proteins are escorted to the proteosome for destruction.This process begins with the covalent attachment of the protein:

The most promising gene therapy strategy for I-cell disease is to:

The first step in the post-translational processing of secreted proteins in eukaryotes is:

Introduction to Biomolecules

Introduction to Protein Structure

Oxygen Transporters: Hemoglobin and Myoglobin

Enzymatic Reactions

Coenzymes

DNA, RNA, and Protein Synthesis

The Human Genome

Introduction to Genetic Diseases

Viruses

DNA Technology

Biological Membranes

The Cytoskeleton

The Extracellular Matrix

Plasma Proteins

Extracellular Messengers

Intracellular Messengers

Cellular Growth Control and Cancer

Digestive Enzymes

Introduction to Metabolic Pathways

Glycolysis, Tricarboxylic Acid Cycle, and Oxidative Phosphorylation

Carbohydrate Metabolism

The Metabolism of Fatty Acids and Triglycerides

The Metabolism of Membrane Lipids

Lipid Transport

Amino Acid Metabolism

Heme Metabolism

The Metabolism of Purines and Pyrimidines

Vitamins and Minerals

Integration of Metabolism

Filters