Question 1

Which of the following poikilocytes would be associated with a hemolytic anemia?

Accepted Answer

A) Oval macrocytes 
B) Echinocytes 
C) Dacryocytes 
D) Spherocytes 
A) Oval macrocytes 
B) Echinocytes 
C) Dacryocytes 
D) Spherocytes D

Question 2

A patient with a bleeding problem is complaining to her physician about excessive fatigue.Physical examination reveals a thin,pale woman with pale mucosal membranes.Significant CBC findings include an MCV of 70 fl.Based on these findings,follow-up testing should be ordered for:

Accepted Answer

A) Iron studies 
B) Vitamin B₁₂ and folate assays 
C) Coagulation screening tests 
D) A bone marrow aspirate 
A) Iron studies 
B) Vitamin B₁₂ and folate assays 
C) Coagulation screening tests 
D) A bone marrow aspirate A

Question 3

An instrument printout indicates that a patient has an RPI of 1.3,hemoglobin of 7 g/dL,and MCV of 112 fl.What can be concluded from this?

Accepted Answer

A) There is acute hemolysis present. 
B) This is the result of iron deficiency. 
C) The anemia is associated with renal disease. 
D) There could be a nuclear maturation defect. 
A) There is acute hemolysis present. 
B) This is the result of iron deficiency. 
C) The anemia is associated with renal disease. 
D) There could be a nuclear maturation defect. D

Question 4

How would you classify an anemic patient whose reticulocyte count is 0.5%?

Accepted Answer

A) Hypoproliferative 
B) Extravascular hemolytic 
C) Maturation defect 
D) Survival defect 
A) Hypoproliferative 
B) Extravascular hemolytic 
C) Maturation defect 
D) Survival defect

Question 5

The finding of a positive direct antiglobulin test (DAT)for a patient is likely to result in which of the following pathologies:

Accepted Answer

A) Increased bone marrow production of erythrocytes 
B) Increased erythrocyte destruction 
C) Decreased bone marrow production of erythrocytes 
D) Liver disease 
A) Increased bone marrow production of erythrocytes 
B) Increased erythrocyte destruction 
C) Decreased bone marrow production of erythrocytes 
D) Liver disease

Question 6

A patient experiencing compensated hemolytic disease would show which of the following lab results?

Accepted Answer

A) RBC count: 2.8 × 10₁₂ /L 
B) MCV: 73 fL 
C) MCHC: 28 g/dL 
D) Hb 15.4 g/dL 
A) RBC count: 2.8 × 10₁₂ /L 
B) MCV: 73 fL 
C) MCHC: 28 g/dL 
D) Hb 15.4 g/dL

Question 7

Blood flow adaptations to anemia are achieved by increasing the respiration rate and _________________

Accepted Answer

A) Increasing the circulation rate. 
B) Decreasing 2,3-BPG 
C) Decreasing cardiac output 
D) Increasing blood viscosity 
A) Increasing the circulation rate. 
B) Decreasing 2,3-BPG 
C) Decreasing cardiac output 
D) Increasing blood viscosity

Question 8

A patient presents with a RPI of >2 and macrocytic morphology of the red blood cells.Which survival defect does this most likely represent?

Accepted Answer

A) B₁₂ deficiency 
B) Folate deficiency 
C) Hemorrhage or hemolysis 
D) Myelodysplasia 
A) B₁₂ deficiency 
B) Folate deficiency 
C) Hemorrhage or hemolysis 
D) Myelodysplasia

Question 9

Which of the following clinical findings is associated with anemia:

Accepted Answer

A) Fatigue 
B) Dyspnea 
C) Skin pallor 
D) All of the above 
A) Fatigue 
B) Dyspnea 
C) Skin pallor 
D) All of the above

Question 10

CBC results on a pregnant patient indicate an MCV of 112 fl.What would be the most appropriate reflex test?

Accepted Answer

A) Iron studies 
B) Bilirubin 
C) LDH 
D) Folate assay 
A) Iron studies 
B) Bilirubin 
C) LDH 
D) Folate assay

Question 11

A patient has hemolytic anemia.An instrument printout reveals a reticulocyte count of 8%,marked polychromasia and moderate schistocytes,and an MCV of 88 fl.What can be concluded about the bone marrow response to this hemolytic anemia?

Accepted Answer

A) It is adequate. 
B) It is not adequate for the degree of hemolysis. 
C) The reticulocyte count indicates that the marrow is responding at its maximum rate. 
D) There is not enough information to determine whether bone marrow response is adequate. 
A) It is adequate. 
B) It is not adequate for the degree of hemolysis. 
C) The reticulocyte count indicates that the marrow is responding at its maximum rate. 
D) There is not enough information to determine whether bone marrow response is adequate.

Question 12

A patient sample had a retic count of 5%.The patient's hematocrit was 25%.Normal hematocrit is 45%.What is the corrected reticulocyte count?

Accepted Answer

A) 3.50% 
B) 2.78% 
C) 5% 
D) 10% 
A) 3.50% 
B) 2.78% 
C) 5% 
D) 10%

Question 13

Which of the following defines hemolysis?

Accepted Answer

A) The destruction of red cells resulting in the release of hemoglobin 
B) The disorder characterized by a decrease in the normal concentration of hemoglobin or erythrocytes 
C) The breakdown product of the heme portion of the hemoglobin molecule 
D) The loss of a large amount of blood either internally or externally 
A) The destruction of red cells resulting in the release of hemoglobin 
B) The disorder characterized by a decrease in the normal concentration of hemoglobin or erythrocytes 
C) The breakdown product of the heme portion of the hemoglobin molecule 
D) The loss of a large amount of blood either internally or externally

Question 14

A patient sample had a retic count of 5% and hematocrit of 25%.Normal hematocrit is 45%.What other bone marrow test(s)could you perform to help determine whether the bone marrow is responding to the pancytopenia?

Accepted Answer

Biopsy specimens cou

Question 15

A bone marrow examination was ordered on a patient with a 6.8 g/dL hemoglobin.The examination revealed an increase in fibrous tissue.This is an indication that the anemia is likely the result of a:

Accepted Answer

A) Proliferation defect 
B) Nuclear maturation defect 
C) Survival defect 
D) Cytoplasmic maturation defect 
A) Proliferation defect 
B) Nuclear maturation defect 
C) Survival defect 
D) Cytoplasmic maturation defect

Question 16

Which of the following is best to measure RBC survival?

Accepted Answer

A) Using conjugated bilirubin 
B) Using urine hemoglobin 
C) Monitoring 51Cr labeled RBCs 
D) Using reticulocyte count 
A) Using conjugated bilirubin 
B) Using urine hemoglobin 
C) Monitoring 51Cr labeled RBCs 
D) Using reticulocyte count

Question 17

Patient results indicate an RPI of 1.8 and an MCV of 10⁹ fl.Do these results make sense?
 Why or why not?

Accepted Answer

Yes,these results make sense.This is the

Question 18

Microcytic hypochromic anemias are associated with which functional abnormality?

Accepted Answer

A) Defective folate utilization 
B) Bone marrow hypoplasia 
C) Fibrotic bone marrow 
D) Defective hemoglobin synthesis 
A) Defective folate utilization 
B) Bone marrow hypoplasia 
C) Fibrotic bone marrow 
D) Defective hemoglobin synthesis

Question 19

The peripheral blood smear of a patient with anemia reveals normochromic RBCs.Which of the following is likely to be the cause of the anemia?

Accepted Answer

A) Thalassemia 
B) Chronic inflammation 
C) Sickle cell anemia 
D) Porphyrias 
A) Thalassemia 
B) Chronic inflammation 
C) Sickle cell anemia 
D) Porphyrias

Question 20

Which of the following represents an example of an intrinsic erythrocyte defect?

Accepted Answer

A) Hb S 
B) Antibody-coated RBCs 
C) Snake venom 
D) Disseminated intravascular coagulation 
A) Hb S 
B) Antibody-coated RBCs 
C) Snake venom 
D) Disseminated intravascular coagulation

Exam 11: Introduction to Anemia

Which of the following poikilocytes would be associated with a hemolytic anemia?

A patient with a bleeding problem is complaining to her physician about excessive fatigue.Physical examination reveals a thin,pale woman with pale mucosal membranes.Significant CBC findings include an MCV of 70 fl.Based on these findings,follow-up testing should be ordered for:

An instrument printout indicates that a patient has an RPI of 1.3,hemoglobin of 7 g/dL,and MCV of 112 fl.What can be concluded from this?

How would you classify an anemic patient whose reticulocyte count is 0.5%?

The finding of a positive direct antiglobulin test (DAT)for a patient is likely to result in which of the following pathologies:

A patient experiencing compensated hemolytic disease would show which of the following lab results?

Blood flow adaptations to anemia are achieved by increasing the respiration rate and _________________

A patient presents with a RPI of >2 and macrocytic morphology of the red blood cells.Which survival defect does this most likely represent?

Which of the following clinical findings is associated with anemia:

CBC results on a pregnant patient indicate an MCV of 112 fl.What would be the most appropriate reflex test?

A patient has hemolytic anemia.An instrument printout reveals a reticulocyte count of 8%,marked polychromasia and moderate schistocytes,and an MCV of 88 fl.What can be concluded about the bone marrow response to this hemolytic anemia?

A patient sample had a retic count of 5%.The patient's hematocrit was 25%.Normal hematocrit is 45%.What is the corrected reticulocyte count?

Which of the following defines hemolysis?

A patient sample had a retic count of 5% and hematocrit of 25%.Normal hematocrit is 45%.What other bone marrow test(s)could you perform to help determine whether the bone marrow is responding to the pancytopenia?

A bone marrow examination was ordered on a patient with a 6.8 g/dL hemoglobin.The examination revealed an increase in fibrous tissue.This is an indication that the anemia is likely the result of a:

Which of the following is best to measure RBC survival?

Patient results indicate an RPI of 1.8 and an MCV of 10⁹ fl.Do these results make sense? Why or why not?

Microcytic hypochromic anemias are associated with which functional abnormality?

The peripheral blood smear of a patient with anemia reveals normochromic RBCs.Which of the following is likely to be the cause of the anemia?

Which of the following represents an example of an intrinsic erythrocyte defect?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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