Question 1

The presence of what poikilocyte would lead to a suspicion of myelophthisic anemia rather than pure red cell aplasia?

Accepted Answer

A) Dacryocyte 
B) Drepanocyte 
C) Schistocyte 
D) Stomatocyte 
A) Dacryocyte 
B) Drepanocyte 
C) Schistocyte 
D) Stomatocyte A

Question 2

Which of the following is among the diagnostic criteria for aplastic anemia?

Accepted Answer

A) Granulocyte count > 0.5 x 10⁹/L B) Platelet count < 20 × 10⁹/L C) Anemia D) Anemia with A) Granulocyte count > 0.5 x 10⁹/L B) Platelet count < 20 × 10⁹/L C) Anemia D) Anemia with B

Question 3

A 3-month-old infant is exhibiting pallor and fatigue.The pediatrician orders a CBC,which displays a low RBC count,H&H,and normal WBC and PLT counts.EPO levels are increased.BM aspirate shows prominent erythroid hypoplasia.Cytogenetic analysis reveals the presence of RPS19 mutation.Based on these findings,what is the patient most likely suffering from?

Accepted Answer

A) CDA II 
B) Pure red cell aplasia 
C) Diamond-Blackfan anemia 
D) Fanconi's syndrome 
A) CDA II 
B) Pure red cell aplasia 
C) Diamond-Blackfan anemia 
D) Fanconi's syndrome C

Question 4

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not?

Accepted Answer

A) Longer life span of some red cells 
B) Superior detoxification 
C) Autoimmune disorders 
D) Lack of exposure 
A) Longer life span of some red cells 
B) Superior detoxification 
C) Autoimmune disorders 
D) Lack of exposure

Question 5

Which of the following describes the bone marrow in a patient with Fanconi's syndrome?

Accepted Answer

A) Hypercellular with erythroid hyperplasia 
B) Hypocellular with normal M:E ratio 
C) Normocellular with decreased M:E ratio 
D) Hypocellular with elevated M:E ratio 
A) Hypercellular with erythroid hyperplasia 
B) Hypocellular with normal M:E ratio 
C) Normocellular with decreased M:E ratio 
D) Hypocellular with elevated M:E ratio

Question 6

Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia.What is the most probable defect causing this rare disorder?

Accepted Answer

A) Deficiency of erythropoietin 
B) Antibodies against erythropoietin 
C) Intrinsic defect of erythroid progenitor cells 
D) Increased reticulocytes 
A) Deficiency of erythropoietin 
B) Antibodies against erythropoietin 
C) Intrinsic defect of erythroid progenitor cells 
D) Increased reticulocytes

Question 7

Which of the following puts a patient taking chloramphenicol at risk for developing aplastic anemia?

Accepted Answer

A) The drug promotes an immune response against stem cells. 
B) The drug is toxic to the bone marrow. 
C) The drug results in stem cell resistance to essential cytokines. 
D) The drug causes decreased cytokine production. 
A) The drug promotes an immune response against stem cells. 
B) The drug is toxic to the bone marrow. 
C) The drug results in stem cell resistance to essential cytokines. 
D) The drug causes decreased cytokine production.

Question 8

Which of the following treatments offers the best prognosis for aplastic anemia?

Accepted Answer

A) Synthetic cytokines 
B) Bone marrow transplant 
C) Immunosuppressive therapy 
D) Stem cell transplant 
A) Synthetic cytokines 
B) Bone marrow transplant 
C) Immunosuppressive therapy 
D) Stem cell transplant

Question 9

Laboratory findings include a blood urea nitrogen >30 mg/dL,serum ferritin levels higher than normal,and a normocytic,normochromic morphology.What cause can be attributed to the anemia?

Accepted Answer

A) Chronic renal disease 
B) Iron deficiency 
C) Diamond-Blackfan anemia 
D) Fanconi's syndrome 
A) Chronic renal disease 
B) Iron deficiency 
C) Diamond-Blackfan anemia 
D) Fanconi's syndrome

Question 10

Define constitutional aplastic anemia,and give an example.

Accepted Answer

Constitutional aplastic anemia

Question 11

Explain how exposure to the following can lead to aplastic anemia.
a.Chloramphenicol
b.Benzene
c.Gamma radiation
d.Starvation

Accepted Answer

a.Bone marrow toxicity
b.Toxicity to com

Question 12

Anemia in hypersplenism differs from anemia found in true hypoproliferative anemias because in hypersplenism,there is:

Accepted Answer

A) Reticulocytosis 
B) Ineffective hematopoiesis 
C) Dyshematopoiesis 
D) Hypoplastic bone marrow 
A) Reticulocytosis 
B) Ineffective hematopoiesis 
C) Dyshematopoiesis 
D) Hypoplastic bone marrow

Question 13

Correlate the prognosis associated with the following treatments for aplastic anemia.
a.Bone marrow transplant
b.Cytokine therapy
c.Stem cell transplant
d.Immunosuppression therapy

Accepted Answer

a.Good prognosis
b.G

Question 14

All of the following are considered diagnostic criteria for aplastic anemia except:

Accepted Answer

A)   
B)   
C)   
D)   
A)   
B)   
C)   
D)

Question 15

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages.What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Accepted Answer

A) Hepatosplenomegaly 
B) Splenomegaly 
C) Lymph node enlargement 
D) Fever 
A) Hepatosplenomegaly 
B) Splenomegaly 
C) Lymph node enlargement 
D) Fever

Question 16

Hypoproliferative anemia is defined as:

Accepted Answer

A) Decreased hematopoiesis in the bone marrow 
B) Decreased hematopoiesis in the liver 
C) Decreased erythropoiesis in the bone marrow 
D) Ineffective erythropoiesis in the bone marrow 
A) Decreased hematopoiesis in the bone marrow 
B) Decreased hematopoiesis in the liver 
C) Decreased erythropoiesis in the bone marrow 
D) Ineffective erythropoiesis in the bone marrow

Question 17

Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:

Accepted Answer

A) Drug exposure 
B) Viral infections 
C) Defective stem cells 
D) Immunologic suppression of hematopoiesis 
A) Drug exposure 
B) Viral infections 
C) Defective stem cells 
D) Immunologic suppression of hematopoiesis

Question 18

Aplastic anemia in the acquired form can result from drugs or chemical agent exposure.If the link cannot be made to any environmental factor,what form of anemia does the client have?

Accepted Answer

A) Pure red cell aplasia 
B) Anemia of chronic renal disease 
C) Idiopathic 
D) Chronic 
A) Pure red cell aplasia 
B) Anemia of chronic renal disease 
C) Idiopathic 
D) Chronic

Question 19

Fanconi's syndrome is an example of:

Accepted Answer

A) Constitutional aplastic anemia 
B) Acquired aplastic anemia 
C) Constitutional anemia from external stimuli 
D) Acquired aplastic anemia from external exposure 
A) Constitutional aplastic anemia 
B) Acquired aplastic anemia 
C) Constitutional anemia from external stimuli 
D) Acquired aplastic anemia from external exposure

Question 20

Which CDA is characterized by a positive Ham test and a negative sucrose lysis test?

Accepted Answer

A) CDA I 
B) CDA II 
C) CDA III 
D) CDA IV 
A) CDA I 
B) CDA II 
C) CDA III 
D) CDA IV

Exam 16: Hypoproliferative Anemias

The presence of what poikilocyte would lead to a suspicion of myelophthisic anemia rather than pure red cell aplasia?

Which of the following is among the diagnostic criteria for aplastic anemia?

What is a viable explanation as to why some individuals suffer stem cell damage when exposed to chemical agents but others do not?

Which of the following describes the bone marrow in a patient with Fanconi's syndrome?

Diamond-Blackfan syndrome anemia is a rare congenital progressive erythrocyte aplasia.What is the most probable defect causing this rare disorder?

Which of the following puts a patient taking chloramphenicol at risk for developing aplastic anemia?

Which of the following treatments offers the best prognosis for aplastic anemia?

Laboratory findings include a blood urea nitrogen >30 mg/dL,serum ferritin levels higher than normal,and a normocytic,normochromic morphology.What cause can be attributed to the anemia?

Define constitutional aplastic anemia,and give an example.

Explain how exposure to the following can lead to aplastic anemia. a.Chloramphenicol b.Benzene c.Gamma radiation d.Starvation

Anemia in hypersplenism differs from anemia found in true hypoproliferative anemias because in hypersplenism,there is:

Correlate the prognosis associated with the following treatments for aplastic anemia. a.Bone marrow transplant b.Cytokine therapy c.Stem cell transplant d.Immunosuppression therapy

All of the following are considered diagnostic criteria for aplastic anemia except:

Aplastic anemia is usually first noted by bleeding and the presence of petechial hemorrhages.What clinical sign in the early stages of the disease should cause doubt on the diagnosis of aplastic anemia?

Hypoproliferative anemia is defined as:

Recent evidence suggests that the pathophysiology of most cases of acquired aplastic anemia is most likely:

Aplastic anemia in the acquired form can result from drugs or chemical agent exposure.If the link cannot be made to any environmental factor,what form of anemia does the client have?

Fanconi's syndrome is an example of:

Which CDA is characterized by a positive Ham test and a negative sucrose lysis test?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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