Question 1

Which of the following physical symptoms are associated with scurvy?

Accepted Answer

A) Hemangiomas 
B) Ecchymoses 
C) Bleeding into joints and muscles 
D) Purpura fulminans 
A) Hemangiomas 
B) Ecchymoses 
C) Bleeding into joints and muscles 
D) Purpura fulminans B

Question 2

What laboratory tests are used to assess disorders of primary hemostasis and secondary hemostasis?

Accepted Answer

•Primary hemostasis: bleeding time, platelet count
•Secondary hemostasis: prothrombin time (PT) and activated partial thromboplastin time (APTT)

Question 3

Predict the typical expected results of clot-based PT in a patient with a platelet defect.

Accepted Answer

A) Prolonged 
B) Normal 
C) Shortened 
D) Cannot be predicted 
A) Prolonged 
B) Normal 
C) Shortened 
D) Cannot be predicted B

Question 4

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Accepted Answer

A) Platelets will show diminished activity with selected agonists. 
B) Platelets will show normal activity with all agonists. 
C) Platelets will show increased activity with selected agonists. 
D) Platelets will show variable activity with all agonists. 
A) Platelets will show diminished activity with selected agonists. 
B) Platelets will show normal activity with all agonists. 
C) Platelets will show increased activity with selected agonists. 
D) Platelets will show variable activity with all agonists.

Question 5

A patient has a splitting headache prior to his blood draw.He takes two aspirin,and his blood is drawn.Platelet aggregation studies are performed,and one comes back abnormal.Based on this information,which agonist will show a normal aggregation pattern?

Accepted Answer

A) Arachidonic acid 
B) Epinephrine 
C) Collagen 
D) Ristocetin 
A) Arachidonic acid 
B) Epinephrine 
C) Collagen 
D) Ristocetin

Question 6

An instrument report has a platelet count of 850 x 10⁹/L.This would be interpreted as:

Accepted Answer

A) Normal platelet count 
B) Thrombocytosis 
C) Thrombocytopenia 
D) Cannot be interpreted 
A) Normal platelet count 
B) Thrombocytosis 
C) Thrombocytopenia 
D) Cannot be interpreted

Question 7

Which hemostatic disorder usually is represented by a decreased platelet count,normal PT,normal APTT,and abnormal bleeding time?

Accepted Answer

A) Thrombocytosis 
B) Thrombocytopenia 
C) Vascular disorder 
D) Platelet dysfunction 
A) Thrombocytosis 
B) Thrombocytopenia 
C) Vascular disorder 
D) Platelet dysfunction

Question 8

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

Accepted Answer

Malignancies contribute to ins

Question 9

A patient's peripheral blood smear reveals many giant platelets.All platelet function tests show normal aggregation with the exception of ristocetin.From what is the patient most likely suffering?

Accepted Answer

A) Glanzmann's thrombasthenia 
B) Bernard-Soulier syndrome 
C) Storage pool disease 
D) Wiskott-Aldrich syndrome 
A) Glanzmann's thrombasthenia 
B) Bernard-Soulier syndrome 
C) Storage pool disease 
D) Wiskott-Aldrich syndrome

Question 10

A patient visits a physician because of unexplained bruising and prolonged bleeding from a recent tooth extraction.The physician orders a prothrombin time (PT)and an APTT.Results are within normal reference ranges.What other tests could the physician order to investigate the patient's symptoms?

Accepted Answer

A) Platelet count and platelet function assays 
B) Platelet function assays 
C) Platelet count only 
D) Repetition of the PT and the APTT after the beginning of treatment 
A) Platelet count and platelet function assays 
B) Platelet function assays 
C) Platelet count only 
D) Repetition of the PT and the APTT after the beginning of treatment

Question 11

What would be the expected laboratory results in a patient with thrombocytopenia?

Accepted Answer

A) Platelet counts <50 × 10⁹/L 
B) Normal bleeding time 
C) Abnormally prolonged PT and APTT 
D) Decreased fibrinogen 
A) Platelet counts <50 × 10⁹/L 
B) Normal bleeding time 
C) Abnormally prolonged PT and APTT 
D) Decreased fibrinogen

Question 12

Which of the following characteristics of chronic ITP differentiates it from acute ITP?

Accepted Answer

A) Platelet count of < 20 × 10⁹/L 
B) Gender predilection in females of 3:1 
C) Duration of 2-6 weeks 
D) Lymphocytosis 
A) Platelet count of < 20 × 10⁹/L 
B) Gender predilection in females of 3:1 
C) Duration of 2-6 weeks 
D) Lymphocytosis

Question 13

Increased risk of bleeding into the central nervous system occurs with a platelet count of:

Accepted Answer

A) 800 x 10⁹/L 
B) 200 x 10⁹/L 
C) 150 x 10⁹/L 
D) 30 x 10⁹/L 
A) 800 x 10⁹/L 
B) 200 x 10⁹/L 
C) 150 x 10⁹/L 
D) 30 x 10⁹/L

Question 14

Describe the following,and indicate whether they are typically seen in disorders of primary or secondary hemostasis.
a.Petechiae
b.Purpura
c.Ecchymoses
d.Hematomas

Accepted Answer

Petechiae: purple pinpoint hemorrhages b

Question 15

A patient is experiencing pinpoint petechial bruising on her upper torso.Her history revealed frequent nosebleeds during her childhood.Clot-based screening assays are within normal reference ranges,and platelet function assays are abnormal.Based on this information,what appears to be defective in this patient?

Accepted Answer

A) Coagulation factors 
B) Platelets 
C) The vasculature 
D) Fibrinolytic system 
A) Coagulation factors 
B) Platelets 
C) The vasculature 
D) Fibrinolytic system

Question 16

Aspirin affects platelet aggregation because it interferes with:

Accepted Answer

A) Cyclooxygenase activity 
B) Platelet adhesion to collagen 
C) Development of platelets 
D) Binding of fibrinogen to platelets 
A) Cyclooxygenase activity 
B) Platelet adhesion to collagen 
C) Development of platelets 
D) Binding of fibrinogen to platelets

Question 17

A patient has a platelet count of 80 x 10⁹/L and a bleeding time of 15 minutes.From what is the patient most likely suffering?

Accepted Answer

A) A platelet function disorder 
B) A quantitative platelet disorder 
C) A combined platelet disorder 
D) von Willebrand disease
Question: Is it good practice to perform a bleeding time on a thrombocytopenic patient? No.Also Bleeding Times are being replaced in many labs by TEG (thromboelastography)and platelet function analyzers (i.e.PFA 100) 
A) A platelet function disorder 
B) A quantitative platelet disorder 
C) A combined platelet disorder 
D) von Willebrand disease
Question: Is it good practice to perform a bleeding time on a thrombocytopenic patient? No.Also Bleeding Times are being replaced in many labs by TEG (thromboelastography)and platelet function analyzers (i.e.PFA 100)

Question 18

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

Accepted Answer

A) Abnormal glycoprotein Ib/IX complex 
B) Abnormal glycoprotein IIb/IIIa 
C) High platelet count 
D) Low fibrinogen level 
A) Abnormal glycoprotein Ib/IX complex 
B) Abnormal glycoprotein IIb/IIIa 
C) High platelet count 
D) Low fibrinogen level

Question 19

What is a common etiology of ITP in children?

Accepted Answer

A) Tooth extraction 
B) Easy bruising syndrome 
C) Vasculitis 
D) Chickenpox 
A) Tooth extraction 
B) Easy bruising syndrome 
C) Vasculitis 
D) Chickenpox

Question 20

What is the condition when petechiae and ecchymoses are found in a higher-than-normal number with less-than-usual trauma?

Accepted Answer

A) Hematoma 
B) Purpura 
C) Easy bruisability 
D) Excess bleeding 
A) Hematoma 
B) Purpura 
C) Easy bruisability 
D) Excess bleeding

Exam 33: Disorders of Primary Hemostasis

Which of the following physical symptoms are associated with scurvy?

What laboratory tests are used to assess disorders of primary hemostasis and secondary hemostasis?

Predict the typical expected results of clot-based PT in a patient with a platelet defect.

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

A patient has a splitting headache prior to his blood draw.He takes two aspirin,and his blood is drawn.Platelet aggregation studies are performed,and one comes back abnormal.Based on this information,which agonist will show a normal aggregation pattern?

An instrument report has a platelet count of 850 x 10⁹/L.This would be interpreted as:

Which hemostatic disorder usually is represented by a decreased platelet count,normal PT,normal APTT,and abnormal bleeding time?

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

A patient's peripheral blood smear reveals many giant platelets.All platelet function tests show normal aggregation with the exception of ristocetin.From what is the patient most likely suffering?

A patient visits a physician because of unexplained bruising and prolonged bleeding from a recent tooth extraction.The physician orders a prothrombin time (PT)and an APTT.Results are within normal reference ranges.What other tests could the physician order to investigate the patient's symptoms?

What would be the expected laboratory results in a patient with thrombocytopenia?

Which of the following characteristics of chronic ITP differentiates it from acute ITP?

Increased risk of bleeding into the central nervous system occurs with a platelet count of:

Describe the following,and indicate whether they are typically seen in disorders of primary or secondary hemostasis. a.Petechiae b.Purpura c.Ecchymoses d.Hematomas

Aspirin affects platelet aggregation because it interferes with:

A patient has a platelet count of 80 x 10⁹/L and a bleeding time of 15 minutes.From what is the patient most likely suffering?

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

What is a common etiology of ITP in children?

What is the condition when petechiae and ecchymoses are found in a higher-than-normal number with less-than-usual trauma?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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