Exam 27: Precursor Lymphoid Neoplasms

A technologist is reviewing a patient's blood smear.She notices that 85% blasts are present but is having a difficult time identifying the lineage.Cytochemical staining is subsequently performed,and the results for MPO,SBB,NSE,and PAS are negative.Based on this information,what is the most likely lineage of the unknown blasts?

Which markers are found on lymphoblasts?

Questions 8-10: Use this case to answer the following questions: A 6-year-old boy was taken to see his pediatrician because of tiny pinpoint spots that had appeared on his upper torso 3 days earlier.A CBC revealed 70% blasts,and a platelet count of 18 × 10⁹/L.A bone marrow aspirate and biopsy indicate a diagnosis of ALL. -Which of the following cytochemical stains would be positive in this case?

A 5-year-old patient has been diagnosed with Pre-B-cell ALL.Routine cytogenetic analysis confirms the presence of the Philadelphia chromosome.What does this mean for the patient?

Define the phases and purposes of chemotherapy for ALL.

Questions 8-10: Use this case to answer the following questions: A 6-year-old boy was taken to see his pediatrician because of tiny pinpoint spots that had appeared on his upper torso 3 days earlier.A CBC revealed 70% blasts,and a platelet count of 18 × 10⁹/L.A bone marrow aspirate and biopsy indicate a diagnosis of ALL. -Cytogenetic analysis confirms the presence of t(1;14).This verifies which of the following types of ALL?

Define acute undifferentiated leukemia and explain why it is difficult to identify.

ALL most often arises from a defect in which of the following?

Which of the following patient populations is most commonly afflicted with ALL?

Which of the following is a positive predictive factor in children with precursor B-ALL?

An immunoglobulin (Ig)gene rearrangement can be identified in all of the following acute lymphoblastic leukemias except:

Summarize and explain why patients develop the clinical signs and symptoms oberserved in patients with ALL.

Which of the following markers would be helpful in differentiating cortical T-cell ALL from medullary T-cell ALL?

Which of the following is a classic morphologic finding in the peripheral blood in ALL?

Which of the following cytochemical stains would be most helpful in differentiating AML from ALL?

A patient has been diagnosed with B-cell ALL.Immunophenotyping has been ordered to confirm the subtype.Which markers would be ideal to help differentiate Pre-B-cell ALL from Pro-B-cell ALL?

The WHO defines acute lymphoblastic leukemia as having a blast count that is which of the following?

B-lymphoblasts in ALL exhibit which one of the following markers that is helpful in their identification?

As part of their disease progression,ALL patients are at risk for developing which of the following?

A peripheral blood smear from a patient with acute leukemia displayed a homogeneous population of small blasts with scanty cytoplasm.Based on this information,which WHO classification is described?