Exam 4: Properties of Drugs

Drug A has a pKa of 8 and Drug B has a pKa of 10.The pH of the local environment is 7.Which drug will diffuse through membranes more effectively?

If a vesicular transporter for a neurotransmitter is blocked,then all of the following could occur except:

Finding that chronic administration of a psychostimulant reduced dopamine receptors in the brain would be an example of:

_____________ refers to an adaption that requires a user to take greater doses of a drug to achieve similar effects.

List and describe three types of neurotoxicity that can occur.

A drug with a Kd=1 nM has a greater binding affinity that an drug with a Kd=100 nM.

__________ tolerance occurs when tolerance for a drug carries over to another drug with similar biological actions.

You are a pharmacologist who recently developed a new therapeutic drug for a brain disorder.Unfortunately,the drug has poor bioavailability.List and describe three potential reasons why the drug had poor bioavailability.

The achievement of a steady-state for a drugs implies the following except:

If a physician informed a patient that she was a poor metabolizer for an anxiolytic drug (drug for treating anxiety),this implies that:

Bioavailabilty reduced specifically for drugs orally administered may be due to:

Passive diffusion is most effective for _____________ drug molecules.

If a pharmacologist needed to develop a drug with a rapid absorption time,which if the following routes might she choose?

A(n)_______________ is a substance that binds to site on a protein and causes a conformational change in the protein,but neither activates nor prevents activation of the protein.

In order to passively diffuse through the blood-brain barrier,a drug must:

__________________ refers to a drug's strength of binding to a receptor .

The drug entacapone inhibits the enzyme catechol-O-methyltransferase (COMT),which causes:

The functions of an antagonist imply that:

In the study by Siegel in the textbook,_____________ tolerance likely occurred for the effects of heroin.

An agonist mimics the effect of a neurotransmitter at a receptor.