Question 1

During metastasis,cells may undergo an epithelial-to-mesenchymal transition whereby there is a(n):

Accepted Answer

A) increase in cell polarity. 
B) loss of cell-cell-adhesion. 
C) down-regulation in the expression of the Snail and Twist transcription factors. 
D) all of the above 
A) increase in cell polarity. 
B) loss of cell-cell-adhesion. 
C) down-regulation in the expression of the Snail and Twist transcription factors. 
D) all of the above B

Question 2

Burkitt's lymphoma results from the overproduction of:

Accepted Answer

A) Fos. 
B) Myc. 
C) Ras. 
D) Src. 
A) Fos. 
B) Myc. 
C) Ras. 
D) Src. B

Question 3

Transgenic mice that express an activated oncogene like rasᴰ under the control of the TetOFF system are likely to undergo which of the following events when tetracycline is given?

Accepted Answer

A) growth of tumors 
B) shrinkage of tumors 
C) no effect on tumors 
D) tumors become metastatic 
A) growth of tumors 
B) shrinkage of tumors 
C) no effect on tumors 
D) tumors become metastatic B

Question 4

What is the multi-hit model of cancer? What data support this model?

Accepted Answer

The multi-hit model proposes that multip

Question 5

Which of the following is(are)a tumor suppressor gene?

Accepted Answer

A) APC 
B) ras 
C) Rb 
D) APC and Rb 
A) APC 
B) ras 
C) Rb 
D) APC and Rb

Question 6

How can DNA microarrays be used to detect gene amplifications in cancer cells?

Accepted Answer

Using genomic DNA from cancer cells as p

Question 7

Explain how the chemotherapeutic drug Gleevec works in the treatment of myelogenous leukemia.

Accepted Answer

Gleevec specifically targets the fusion

Question 8

MicroRNAs are a new class of oncogenic factors because they function:

Accepted Answer

A) as tumor suppressors. 
B) as oncogenes. 
C) to induce errors during DNA replication. 
D) as tumor suppressors and as oncogenes. 
A) as tumor suppressors. 
B) as oncogenes. 
C) to induce errors during DNA replication. 
D) as tumor suppressors and as oncogenes.

Question 9

Ras is a:

Accepted Answer

A) growth factor. 
B) kinase. 
C) phosphatase. 
D) none of the above 
A) growth factor. 
B) kinase. 
C) phosphatase. 
D) none of the above

Question 10

What renders erbB and her2 oncogenic? What are their normal proto-oncogene counterparts?

Accepted Answer

ErbB and her2 both encode constitutively

Question 11

Cancer genome analysis has been utilized for all the following applications,except:

Accepted Answer

A) to identify which patients are good candidates for molecularly targeted drugs. 
B) to identify cancerous cells in a biopsy based on morphological characteristics. 
C) to identify driver mutations. 
D) to identify the link between chromothripsis and aggressive neuroblastoma. 
A) to identify which patients are good candidates for molecularly targeted drugs. 
B) to identify cancerous cells in a biopsy based on morphological characteristics. 
C) to identify driver mutations. 
D) to identify the link between chromothripsis and aggressive neuroblastoma.

Question 12

Name the six fundamental properties of malignant tumors.Which of these properties are amenable to study in a cell culture model of cancer?

Accepted Answer

Malignant tumors exhibit (1)self-suffici

Question 13

The human papillomavirus E7 protein inhibits the function of:

Accepted Answer

A) p53. 
B) Rb. 
C) PDGF receptor. 
D) all of the above 
A) p53. 
B) Rb. 
C) PDGF receptor. 
D) all of the above

Question 14

Which of the following is a characteristic of malignant tumors?

Accepted Answer

A) localized to tissue of origin 
B) metastatic 
C) well differentiated 
D) sense signals that restrict cell division 
A) localized to tissue of origin 
B) metastatic 
C) well differentiated 
D) sense signals that restrict cell division

Question 15

A gain-of-function mutation in _____ will bypass restriction point controls.

Accepted Answer

A) cyclin D 
B) p16 
C) Rb 
D) cyclin D and p16 
A) cyclin D 
B) p16 
C) Rb 
D) cyclin D and p16

Question 16

If colon cancers could be prevented by intervening in the earliest molecular changes during multi-hit progression,the molecule you would target for intervention would be:

Accepted Answer

A) p53. 
B) Ras. 
C) APC. 
D) VEGF. 
A) p53. 
B) Ras. 
C) APC. 
D) VEGF.

Question 17

Gain-of-function mutations in which of the following genes typify colorectal carcinomas?

Accepted Answer

A) APC 
B) p53 
C) K-ras 
D) all of the above 
A) APC 
B) p53 
C) K-ras 
D) all of the above

Question 18

Which of the following is NOT a microscopic characteristic of tumor cells?

Accepted Answer

A) high nuclear to cytoplasmic ratio 
B) greater percentage of mitotic cells 
C) larger size 
D) few specialized structures 
A) high nuclear to cytoplasmic ratio 
B) greater percentage of mitotic cells 
C) larger size 
D) few specialized structures

Question 19

Which of the following proteins belong to the control system that regulates cells past a certain point in late G₁ (START)?

Accepted Answer

A) CDK4 
B) cyclin B 
C) Rb 
D) CDK4 and Rb 
A) CDK4 
B) cyclin B 
C) Rb 
D) CDK4 and Rb

Question 20

Describe the Warburg effect and how it applies to cancer cells.

Accepted Answer

Otto Warburg described how can

Exam 23: Cancer

During metastasis,cells may undergo an epithelial-to-mesenchymal transition whereby there is a(n):

Burkitt's lymphoma results from the overproduction of:

Transgenic mice that express an activated oncogene like rasᴰ under the control of the TetOFF system are likely to undergo which of the following events when tetracycline is given?

What is the multi-hit model of cancer? What data support this model?

Which of the following is(are)a tumor suppressor gene?

How can DNA microarrays be used to detect gene amplifications in cancer cells?

Explain how the chemotherapeutic drug Gleevec works in the treatment of myelogenous leukemia.

MicroRNAs are a new class of oncogenic factors because they function:

Ras is a:

What renders erbB and her2 oncogenic? What are their normal proto-oncogene counterparts?

Cancer genome analysis has been utilized for all the following applications,except:

Name the six fundamental properties of malignant tumors.Which of these properties are amenable to study in a cell culture model of cancer?

The human papillomavirus E7 protein inhibits the function of:

Which of the following is a characteristic of malignant tumors?

A gain-of-function mutation in _____ will bypass restriction point controls.

If colon cancers could be prevented by intervening in the earliest molecular changes during multi-hit progression,the molecule you would target for intervention would be:

Gain-of-function mutations in which of the following genes typify colorectal carcinomas?

Which of the following is NOT a microscopic characteristic of tumor cells?

Which of the following proteins belong to the control system that regulates cells past a certain point in late G₁ (START)?

Describe the Warburg effect and how it applies to cancer cells.

Chemical Foundations

Molecular Genetic Techniques

Protein Structure and Function

Culturing and Visualizing Cells

Fundamental Molecular Genetic Mechanisms

Bio-membrane Structure

Genes Genomics and Chromosomes

Transcriptional Control of Gene Expression

Post-Transcriptional Gene Control

Transmembrane Transport of Ions and Small Molecules

Cellular Energetics

Moving Proteins Into Membranes and Organelles

Vesicular Traffic, Secretion, and Endocytosis

Signal Transduction and G-Protein Coupled Receptors

Signaling Pathways That Control Gene Activity

Cell Organization and Movement I: Microfilaments

Cell Organization and Movement II: Microtubules and Intermediate Filaments

Regulating the Eukaryotic Cell Cycle

Integrating Cells Into Tissues

Cell Birth, Lineage, and Death

Nerve Cells

Immunology

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