Question 1

Matching
-Sickle cell hemoglobin does not form fibers in the ______ form.

Accepted Answer

A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial 
A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial E

Question 2

The reaction of carbonic anhydrase catalyzes

Accepted Answer

A) the formation of carbamates with the concomitant release of protons. 
B) the hydration of bicarbonate, resulting in the formation of carbonic acid. 
C) the reduction of carbon dioxide with the concomitant consumption of protons. 
D) the hydration of carbon dioxide, forming bicarbonate and protons. 
E) the hydrolysis of carbamates with the concomitant consumption of protons. 
A) the formation of carbamates with the concomitant release of protons. 
B) the hydration of bicarbonate, resulting in the formation of carbonic acid. 
C) the reduction of carbon dioxide with the concomitant consumption of protons. 
D) the hydration of carbon dioxide, forming bicarbonate and protons. 
E) the hydrolysis of carbamates with the concomitant consumption of protons. D

Question 3

Myoglobin and a single chain of hemoglobin have similar ______ structures.

Accepted Answer

A) primary 
B) secondary 
C) tertiary 
D) quaternary 
E) none of the above 
A) primary 
B) secondary 
C) tertiary 
D) quaternary 
E) none of the above C

Question 4

When the partial pressure of O2 in venous blood is 30 torr, the saturation of myoglobin with O2 is ______ while the saturation of hemoglobin with O2 is ______.

Accepted Answer

A) 0.55, 0.91 
B) 0.91, 0.55 
C) 2.8 torr, 26 torr 
D) 0.91, 0.97 
E) none of the above 
A) 0.55, 0.91 
B) 0.91, 0.55 
C) 2.8 torr, 26 torr 
D) 0.91, 0.97 
E) none of the above

Question 5

Why is the decreased affinity of fetal hemoglobin for BPG advantageous?

Accepted Answer

A) With fewer BPG molecules bound there are more heme residues available for O2 binding. 
B) Decreased BPG binding biases the fetal hemoglobin toward the R state. 
C) More free BPG is available to bind to adult hemoglobin, resulting in a shift to the R state. 
D) BPG is available to bind to fetal myoglobin, helping to release O2 in fetal muscle tissue. 
E) none of the above 
A) With fewer BPG molecules bound there are more heme residues available for O2 binding. 
B) Decreased BPG binding biases the fetal hemoglobin toward the R state. 
C) More free BPG is available to bind to adult hemoglobin, resulting in a shift to the R state. 
D) BPG is available to bind to fetal myoglobin, helping to release O2 in fetal muscle tissue. 
E) none of the above

Question 6

IgG is the most common immunoglobulin in the circulatory system and in the extravascular fluid.It is composed of two light chains and two heavy chains.What is the approximate molecular mass of an IgG molecule?

Accepted Answer

A) 23 kDa 
B) 75 kDa 
C) 150 kDa 
D) 360 kDa 
E) 950 kDa 
A) 23 kDa 
B) 75 kDa 
C) 150 kDa 
D) 360 kDa 
E) 950 kDa

Question 7

IgG is one of five classes of antibodies that can be produced by our immune system.IgGs have a molecular mass of approximately 150 kDa, what is their subunit composition?

Accepted Answer

A) 2 light chains and 2 heavy chains 
B) 2 light chains, 2 heavy chains, and a J chain 
C) 4 light chains, 4 heavy chains, and a J chain 
D) 6 light chains, 6 heavy chains, and a J chain 
E) 10 light chains, 10 heavy chains , and a J chain. 
A) 2 light chains and 2 heavy chains 
B) 2 light chains, 2 heavy chains, and a J chain 
C) 4 light chains, 4 heavy chains, and a J chain 
D) 6 light chains, 6 heavy chains, and a J chain 
E) 10 light chains, 10 heavy chains , and a J chain.

Question 8

During muscle contraction

Accepted Answer

A) myosin pulls actin filaments toward the M disk. 
B) myosin pushes actin filaments toward the Z disk. 
C) actin pulls myosin toward the Z disk. 
D) actin pushes myosin toward the M disk. 
E) All of the answers above are correct. 
A) myosin pulls actin filaments toward the M disk. 
B) myosin pushes actin filaments toward the Z disk. 
C) actin pulls myosin toward the Z disk. 
D) actin pushes myosin toward the M disk. 
E) All of the answers above are correct.

Question 9

Matching
-An increase in pCO2 causes hemoglobin's affinity for oxygen to ______.

Accepted Answer

A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial 
A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial

Question 10

Matching
-In the ______ state of hemoglobin, the iron ion is out of the plane of the porphyrin ring.

Accepted Answer

A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial 
A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial

Question 11

The Ig fold can be described as a

Accepted Answer

A) globular fold composed of $\alpha$ helices. 
B) a globular fold composed of a four helix bundle. 
C) a globular fold composed of a $\beta$ sandwich. 
D) a globular fold composed of $\beta$ barrel. 
E) a coiled-coil. 
A) globular fold composed of $\alpha$ helices. 
B) a globular fold composed of a four helix bundle. 
C) a globular fold composed of a $\beta$ sandwich. 
D) a globular fold composed of $\beta$ barrel. 
E) a coiled-coil.

Question 12

Humoral immunity is mediated by soluble molecules.Which cell type produces the soluble molecules that carry out the humoral immunity?

Accepted Answer

A) T cells 
B) B cells 
C) macrophages 
D) neutrophils 
E) monocytes 
A) T cells 
B) B cells 
C) macrophages 
D) neutrophils 
E) monocytes

Question 13

Treadmilling refers to

Accepted Answer

A) myosin heads walking along actin microfilaments. 
B) actin and myosin filaments sliding along each other. 
C) actin monomers moving through a microfilament from the + end to the - end. 
D) synthesis and degradation of actin monomers. 
E) the interactions between actin and tropomyosin. 
A) myosin heads walking along actin microfilaments. 
B) actin and myosin filaments sliding along each other. 
C) actin monomers moving through a microfilament from the + end to the - end. 
D) synthesis and degradation of actin monomers. 
E) the interactions between actin and tropomyosin.

Question 14

Myoglobin is an oxygen binding protein in muscle.Describe in one sentence the overall structure of myoglobin.

Accepted Answer

Myoglobin is a globular protei

Question 15

Which statement about myosin is not true?

Accepted Answer

A) Myosin is a heterohexamer. 
B) Myosin contains two globular heads. 
C) Myosin contains six different polypeptides 
D) Myosin aggregates to form thick filaments 
E) All of the answers above are true of myosin. 
A) Myosin is a heterohexamer. 
B) Myosin contains two globular heads. 
C) Myosin contains six different polypeptides 
D) Myosin aggregates to form thick filaments 
E) All of the answers above are true of myosin.

Question 16

Which of the following statements about the symmetry model of allosterism is not true?

Accepted Answer

A) the protein is an oligomer of symmetrically (or pseudosymmetrically)related subunits. 
B) the oligomer can exist in two conformational states, which are in equilibrium. 
C) the ligand can bind to a subunit in either conformation. 
D) the molecular symmetry of the protein is conserved during the conformational change. 
E) none of the above. 
A) the protein is an oligomer of symmetrically (or pseudosymmetrically)related subunits. 
B) the oligomer can exist in two conformational states, which are in equilibrium. 
C) the ligand can bind to a subunit in either conformation. 
D) the molecular symmetry of the protein is conserved during the conformational change. 
E) none of the above.

Question 17

What is the type of symmetry that relates the protomers in hemoglobin with respect to each other?

Accepted Answer

A) C2 
B) C4 
C) D2 
D) D4 
E) Tetrahedral symmetry 
A) C2 
B) C4 
C) D2 
D) D4 
E) Tetrahedral symmetry

Question 18

Hemoglobin S, the variant responsible for the misshapen red blood cells characteristic of the disease sickle-cell anemia, is potentially advantageous to heterozygotes because it confers some level of resistance to the disease _________.

Accepted Answer

A) rickets 
B) AIDS 
C) cyanosis 
D) polycythemia 
E) malaria 
A) rickets 
B) AIDS 
C) cyanosis 
D) polycythemia 
E) malaria

Question 19

BPG stands for

Accepted Answer

A) biphenylglycine. 
B) boronylphenylglutamate. 
C) bisphosphoglycerate. 
D) bisphenylglycerol. 
E) betapropylglutamine. 
A) biphenylglycine. 
B) boronylphenylglutamate. 
C) bisphosphoglycerate. 
D) bisphenylglycerol. 
E) betapropylglutamine.

Question 20

Matching
-The conversion of hemoglobin from the T to the R state requires breaking of ______ involving C-terminal residues.

Accepted Answer

A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial 
A) positively cooperative 
B) cyanosis 
C) His E7 
D) decrease 
E) R
F)hydrogen bonds
G)increase
H)symmetry
I)His F8
J)ion pairs
K)T
L)hemolytic anemia
M)sequencial

Exam 7: Protein Function Part I: Myoglobin and Hemoglobin

Matching -Sickle cell hemoglobin does not form fibers in the ______ form.

The reaction of carbonic anhydrase catalyzes

Myoglobin and a single chain of hemoglobin have similar ______ structures.

When the partial pressure of O2 in venous blood is 30 torr, the saturation of myoglobin with O2 is ______ while the saturation of hemoglobin with O2 is ______.

Why is the decreased affinity of fetal hemoglobin for BPG advantageous?

IgG is the most common immunoglobulin in the circulatory system and in the extravascular fluid.It is composed of two light chains and two heavy chains.What is the approximate molecular mass of an IgG molecule?

IgG is one of five classes of antibodies that can be produced by our immune system.IgGs have a molecular mass of approximately 150 kDa, what is their subunit composition?

During muscle contraction

Matching -An increase in pCO2 causes hemoglobin's affinity for oxygen to ______.

Matching -In the ______ state of hemoglobin, the iron ion is out of the plane of the porphyrin ring.

The Ig fold can be described as a

Humoral immunity is mediated by soluble molecules.Which cell type produces the soluble molecules that carry out the humoral immunity?

Treadmilling refers to

Myoglobin is an oxygen binding protein in muscle.Describe in one sentence the overall structure of myoglobin.

Which statement about myosin is not true?

Which of the following statements about the symmetry model of allosterism is not true?

What is the type of symmetry that relates the protomers in hemoglobin with respect to each other?

Hemoglobin S, the variant responsible for the misshapen red blood cells characteristic of the disease sickle-cell anemia, is potentially advantageous to heterozygotes because it confers some level of resistance to the disease _________.

BPG stands for

Matching -The conversion of hemoglobin from the T to the R state requires breaking of ______ involving C-terminal residues.

Introduction to the Chemistry of Life

Water

Nucleotides, Nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, Inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glycogen Metabolism and Gluconeogenesis

Glucose Catabolism

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

Dna Replication, Repair and Recombination

Transcription and Rna Processing

Translation

Regulation of Gene Expression

Filters

When the partial pressure of O₂ in venous blood is 30 torr, the saturation of myoglobin with O₂ is while the saturation of hemoglobin with O₂ is .

Matching -An increase in pCO₂ causes hemoglobin's affinity for oxygen to ______.