Question 1

The first step in pyrimidine biosynthesis is the formation of

Accepted Answer

A) carbamoyl phosphate. 
B) carbamoyl aspartate. 
C) β-aminoisobutyrate. 
D) dihydroorotate. 
E) none of the above 
A) carbamoyl phosphate. 
B) carbamoyl aspartate. 
C) β-aminoisobutyrate. 
D) dihydroorotate. 
E) none of the above

Question 2

The amino group added to the C6 position of IMP to form AMP is derived from

Accepted Answer

A) aspartate. 
B) asparagine. 
C) glutamine. 
D) ($\alpha$-ketoglutarate.) 
E) arginine. 
A) aspartate. 
B) asparagine. 
C) glutamine. 
D) ($\alpha$-ketoglutarate.) 
E) arginine.

Question 3

Which of the following is not required for purine biosynthesis?
I.aspartate
II.glycine
III.glutamine
IV.formyl addition to tetrahydrofolate

Accepted Answer

A) I only 
B) II, IV 
C) II, III 
D) IV only 
E) All of the above are required. 
A) I only 
B) II, IV 
C) II, III 
D) IV only 
E) All of the above are required.

Question 4

Which of the following is correct regarding pyrimidine synthesis?

Accepted Answer

A) carbamoyl phosphate + PRPP  aspartate + Pi + dihydroorotate 
B) carbamoyl phosphate + aspartate +   Orotate + Pi + H2O + reduced quinone 
C) dihydroorotate + quinone  orotate + reduced quinine 
D) A and C 
E) None of the above 
A) carbamoyl phosphate + PRPP  aspartate + Pi + dihydroorotate 
B) carbamoyl phosphate + aspartate +   Orotate + Pi + H2O + reduced quinone 
C) dihydroorotate + quinone  orotate + reduced quinine 
D) A and C 
E) None of the above

Question 5

Myoadenylate deaminase deficiency is most evident in ______ tissue.

Accepted Answer

A) liver 
B) connective 
C) neural 
D) muscle 
E) brain 
A) liver 
B) connective 
C) neural 
D) muscle 
E) brain

Question 6

Hydroxylation of IMP to form GMP occurs in conjunction with the ________ of _______.

Accepted Answer

A) oxidation; NADH 
B) reduction; NAD+ 
C) oxidation; NADPH 
D) reduction; NADP+ 
E) none of the above 
A) oxidation; NADH 
B) reduction; NAD+ 
C) oxidation; NADPH 
D) reduction; NADP+ 
E) none of the above

Question 7

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-______ compounds are effective anticancer agents.

Accepted Answer

A) fumarate 
B) NADPH 
C) salvage 
D) uric acid 
E) oxidation
F)XMP
G)iron
H)allopurinol
I)IMP
J)Oxidation
K)therapeutic
L)suicide
M)molybdenum
N)FADH
O)Malonyl-CoA
P)reduction
Q)antifolate 
A) fumarate 
B) NADPH 
C) salvage 
D) uric acid 
E) oxidation
F)XMP
G)iron
H)allopurinol
I)IMP
J)Oxidation
K)therapeutic
L)suicide
M)molybdenum
N)FADH
O)Malonyl-CoA
P)reduction
Q)antifolate

Question 8

What category of reaction converts orotate monophosphate (OMP)into uracil monophosphate (UMP)?

Accepted Answer

A) a transamination 
B) a methylation 
C) a decarboxylation 
D) a carboxylation 
E) none of the above 
A) a transamination 
B) a methylation 
C) a decarboxylation 
D) a carboxylation 
E) none of the above

Question 9

Which of the following sequences for uric acid catabolism is correct for marine invertebrates?

Accepted Answer

A) uric acid $\rarr$ allantoin$\rarr$ allantoic acid$\rarr$ urea$\rarr$ NH4+ 
B) uric acid $\rarr$  allantoic acid$\rarr$ urea$\rarr$ NH4+ 
C) uric acid $\rarr$ allantoin$\rarr$  urea$\rarr$ NH4+ 
D) uric acid $\rarr$ allantoin$\rarr$ allantoic acid$\rarr$ urea 
E) none of the above 
A) uric acid $\rarr$ allantoin$\rarr$ allantoic acid$\rarr$ urea$\rarr$ NH4+ 
B) uric acid $\rarr$  allantoic acid$\rarr$ urea$\rarr$ NH4+ 
C) uric acid $\rarr$ allantoin$\rarr$  urea$\rarr$ NH4+ 
D) uric acid $\rarr$ allantoin$\rarr$ allantoic acid$\rarr$ urea 
E) none of the above

Question 10

Which of the following statements about nucleotide synthesis is (are)true?
I.Most dietary nucleotides are salvaged and used in DNA synthesis.
II.Most nucleotides in cells are from de novo pathways.
III.Most nucleotides in cells are salvaged and used in RNA synthesis.

Accepted Answer

A) I, II 
B) I only 
C) II only 
D) II, IV 
E) III only 
A) I, II 
B) I only 
C) II only 
D) II, IV 
E) III only

The first step in pyrimidine biosynthesis is the formation of

The amino group added to the C6 position of IMP to form AMP is derived from

Which of the following is not required for purine biosynthesis? I.aspartate II.glycine III.glutamine IV.formyl addition to tetrahydrofolate

Which of the following is correct regarding pyrimidine synthesis?

Myoadenylate deaminase deficiency is most evident in ______ tissue.

Hydroxylation of IMP to form GMP occurs in conjunction with the __ of _.

Matching Choose the correct answer from the list. Not all the answers will be used. -______ compounds are effective anticancer agents.

What category of reaction converts orotate monophosphate (OMP)into uracil monophosphate (UMP)?

Which of the following sequences for uric acid catabolism is correct for marine invertebrates?

Which of the following statements about nucleotide synthesis is (are)true? I.Most dietary nucleotides are salvaged and used in DNA synthesis. II.Most nucleotides in cells are from de novo pathways. III.Most nucleotides in cells are salvaged and used in RNA synthesis.

Introduction to the Chemistry of Life

Water

Nucleotides, Nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, Inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glycogen Metabolism and Gluconeogenesis

Glucose Catabolism

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleic Acid Structure

Dna Replication, Repair and Recombination

Transcription and Rna Processing

Translation

Regulation of Gene Expression

Filters

Exam 23: Nucleotide Metabolism

The first step in pyrimidine biosynthesis is the formation of

The amino group added to the C6 position of IMP to form AMP is derived from

Which of the following is not required for purine biosynthesis? I.aspartate II.glycine III.glutamine IV.formyl addition to tetrahydrofolate

Which of the following is correct regarding pyrimidine synthesis?

Myoadenylate deaminase deficiency is most evident in ______ tissue.

Hydroxylation of IMP to form GMP occurs in conjunction with the ________ of _______.

Matching Choose the correct answer from the list. Not all the answers will be used. -______ compounds are effective anticancer agents.

What category of reaction converts orotate monophosphate (OMP)into uracil monophosphate (UMP)?

Which of the following sequences for uric acid catabolism is correct for marine invertebrates?

Which of the following statements about nucleotide synthesis is (are)true? I.Most dietary nucleotides are salvaged and used in DNA synthesis. II.Most nucleotides in cells are from de novo pathways. III.Most nucleotides in cells are salvaged and used in RNA synthesis.

Introduction to the Chemistry of Life

Water

Nucleotides, Nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, Inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glycogen Metabolism and Gluconeogenesis

Glucose Catabolism

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleic Acid Structure

Dna Replication, Repair and Recombination

Transcription and Rna Processing

Translation

Regulation of Gene Expression

Filters

Hydroxylation of IMP to form GMP occurs in conjunction with the __ of _.