Question 1

Matching

-When unstable hemoglobin is degraded;degradation products often cause cell lysis,leading to a condition called ______.

Accepted Answer

A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial 
A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial

Question 2

The primary structure of mammalian hemoglobin,an $\alpha$2$\beta$2 tetramer,is approximately _____ identical to myoglobin.

Accepted Answer

A) 2% 
B) 18% 
C) 50% 
D) 78% 
E) 98% 
A) 2% 
B) 18% 
C) 50% 
D) 78% 
E) 98%

Question 3

Matching

-An increase in pCO2 causes hemoglobin's affinity for oxygen to ______.

Accepted Answer

A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial 
A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial

Question 4

How many antigen-binding sites are present on an IgG molecule?

Accepted Answer

A) 1 
B) 2 
C) 3 
D) 4 
E) 5 
A) 1 
B) 2 
C) 3 
D) 4 
E) 5

Question 5

Some abnormal hemoglobins have Hill coefficients that are ______ that of normal hemoglobin,indicating that their ability to bind oxygen cooperatively has been compromised.

Accepted Answer

A) less than 
B) greater than 
C) much greater than 
D) about equal to 
E) The correct answer cannot be determined from the information given. 
A) less than 
B) greater than 
C) much greater than 
D) about equal to 
E) The correct answer cannot be determined from the information given.

Question 6

Matching

-The conversion of hemoglobin from the T to the R state requires breaking of ______ involving C-terminal residues.

Accepted Answer

A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial 
A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial

Question 7

Which of the following statements about the symmetry model of allosterism is not true?

Accepted Answer

A) the protein is an oligomer of symmetrically (or pseudosymmetrically)related subunits. 
B) the oligomer can exist in two conformational states,which are in equilibrium. 
C) the ligand can bind to a subunit in either conformation. 
D) the molecular symmetry of the protein is conserved during the conformational change. 
E) none of the above. 
A) the protein is an oligomer of symmetrically (or pseudosymmetrically)related subunits. 
B) the oligomer can exist in two conformational states,which are in equilibrium. 
C) the ligand can bind to a subunit in either conformation. 
D) the molecular symmetry of the protein is conserved during the conformational change. 
E) none of the above.

Question 8

How many different classes of antibodies are produced by the human immune system?

Accepted Answer

A) 1 
B) 2 
C) 3 
D) 4 
E) 5 
A) 1 
B) 2 
C) 3 
D) 4 
E) 5

Question 9

Matching

-In the ______ state of hemoglobin,the iron ion is out of the plane of the porphyrin ring.

Accepted Answer

A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial 
A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial

Question 10

BPG stands for

Accepted Answer

A) biphenylglycine. 
B) boronylphenylglutamate. 
C) bisphosphoglycerate. 
D) bisphenylglycerol. 
E) betapropylglutamine. 
A) biphenylglycine. 
B) boronylphenylglutamate. 
C) bisphosphoglycerate. 
D) bisphenylglycerol. 
E) betapropylglutamine.

Question 11

Matching

-When oxygen binds to heme,the oxygen forms a hydrogen bond with ______.

Accepted Answer

A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial 
A)  positively cooperative 
B)  cyanosis 
C)  His E7 
D)  decrease 
E)  R
F) hydrogen bonds
G) increase
H) symmetry
I) His F8
J) ion pairs
K) T
L) hemolytic anemia
M) sequencial

Question 12

The oxygen binding by hemocyanins is mediated by

Accepted Answer

A) an iron ion 
B) a pair of iron ions 
C) a heme group 
D) a copper atom 
E) a pair of copper atoms 
A) an iron ion 
B) a pair of iron ions 
C) a heme group 
D) a copper atom 
E) a pair of copper atoms

Question 13

Which of the statements about muscle contraction is correct?

Accepted Answer

A) During muscle contraction the sarcomere becomes shorter. 
B) During muscle contraction the I band becomes shorter. 
C) During muscle contraction the H zone becomes shorter. 
D) During muscle contraction the distance between the Z disk and the M disk becomes shorter. 
E) All of the answers above are correct. 
A) During muscle contraction the sarcomere becomes shorter. 
B) During muscle contraction the I band becomes shorter. 
C) During muscle contraction the H zone becomes shorter. 
D) During muscle contraction the distance between the Z disk and the M disk becomes shorter. 
E) All of the answers above are correct.

Question 14

Which of the following increases the affinity of hemoglobin for O2?

Accepted Answer

A) an increase in BPG concentration 
B) the formation of N-terminal carbamates 
C) an increase in pH 
D) a decrease in pH 
E) an increase in CO2 concentration 
A) an increase in BPG concentration 
B) the formation of N-terminal carbamates 
C) an increase in pH 
D) a decrease in pH 
E) an increase in CO2 concentration

Exam 7: Protein Function Part I: Myoglobin and Hemoglobin

Matching -When unstable hemoglobin is degraded;degradation products often cause cell lysis,leading to a condition called ______.

The primary structure of mammalian hemoglobin,an α\alphaα 2 β\betaβ 2 tetramer,is approximately _____ identical to myoglobin.

Matching -An increase in pCO2 causes hemoglobin's affinity for oxygen to ______.

How many antigen-binding sites are present on an IgG molecule?

Some abnormal hemoglobins have Hill coefficients that are ______ that of normal hemoglobin,indicating that their ability to bind oxygen cooperatively has been compromised.

Matching -The conversion of hemoglobin from the T to the R state requires breaking of ______ involving C-terminal residues.

Which of the following statements about the symmetry model of allosterism is not true?

How many different classes of antibodies are produced by the human immune system?

Matching -In the ______ state of hemoglobin,the iron ion is out of the plane of the porphyrin ring.

BPG stands for

Matching -When oxygen binds to heme,the oxygen forms a hydrogen bond with ______.

The oxygen binding by hemocyanins is mediated by

Which of the statements about muscle contraction is correct?

Which of the following increases the affinity of hemoglobin for O2?

Introduction to the Chemistry of Life

Water

Nucleotides, nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glucose Catabolism

Glycogen Metabolism and Gluconeogenesis

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

DNA Replication, repair and Recombination

Transcription and Rna Processing

Protein Synthesis

Regulation of Gene Expression

Filters

The primary structure of mammalian hemoglobin,an $\alpha$ ₂ $\beta$ ₂ tetramer,is approximately _____ identical to myoglobin.

Matching -An increase in pCO₂ causes hemoglobin's affinity for oxygen to ______.

Which of the following increases the affinity of hemoglobin for O₂?