Exam 8: Immunodeficiency-Diseases

Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in B cell maturation at the pre-B cell stage caused by mutations in the gene encoding the B cell tyrosine kinase (Btk),resulting in undetectable levels of serum Ig

Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in lymphocyte activation due to mutations in the gene encoding the SAP adapter protein required for inhibition of signaling by the SLAM molecule.Lack of SAP results in uncontrolled B cell proliferation,hypogammaglobulinemia,and B cell lymphoma in the setting of Epstein-Barr virus (EBV)infection.

Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in phagocyte microbicidal activity as a result of defective production of reactive oxygen intermediates,most commonly from a mutation in the gene encoding cytochrome b558

The progression of HIV infection to AIDS is most directly due to which of the following?

Which one of the following is typically NOT associated with T cell immunodeficiencies?

Match each of the following descriptions in questions with the appropriate disease (A-G). -Defect in leukocyte adhesion-dependent functions,resulting from mutations in the gene encoding the CD18 integrin β chain,and leading to recurrent bacterial and fungal infections

A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH)responses,as described in question 3,is called:

All of the following may result in an acquired immunodeficiency EXCEPT:

Which of the following is not a valid explanation for why patients cannot eradicate HIV infections?

In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH)response to a Candida antigen skin challenge?

Which molecules on the T cell surface are directly involved in HIV infection?

Match each of the following descriptions in questions with the appropriate disease (A-G). -Impaired CD4+ T cell development and activation,resulting in defective cell-mediated immunity and impaired T cell-dependent humoral immunity H.