Exam 19: Transplantation

For each of the descriptions in questions ,choose the blood group antigen (A-E)that best matches it. -The blood group of a red blood cell blood donor than can be transfused to any recipient.

Which type of molecules are the most frequent target of allogeneic immune responses against transplanted organs and why?

For each of the descriptions in questions ,choose the blood group antigen (A-E)that best matches it. -Antibodies specific for this blood group found in a person with type A blood.

For each of the descriptions in questions ,choose the blood group antigen (A-E)that best matches it. -Blood group of a person whose red blood cells can only transfused to a person with the same blood group

Which of the following is a correct description of direct T cell recognition of allogeneic MHC molecules by graft recipients?

For each of the descriptions in questions ,choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I)that best matches it. -Inhibits macrophage cytokine secretion

For each of the descriptions in questions ,choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I)that best matches it. -Blocks calcineurin-dependent activation of NFAT

For each of the descriptions in questions ,choose the blood group antigen (A-E)that best matches it. -Nonglycosylated red cell membrane protein missing or mutated in 15% of humans

For each of the descriptions in questions ,choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I)that best matches it. -Can induce anergy in T cells through inhibition of costimulatory signaling

Allogeneic immune responses lead to graft rejection.Which of the following best defines an allogeneic immune response in human-to-human transplantation?

For each of the descriptions in questions ,choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I)that best matches it. -Inhibits mTOR,and thereby inhibits IL-2 driven cell cycle progression in T cells

For each of the descriptions in questions ,choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I)that best matches it. -Inhibits a lymphocyte-specific isoform of inosine monophosphate dehydrogenase,an enzyme that is required for the synthesis of guanine nucleotides

A kidney is transplanted into a patient with renal failure to diabetes,and within 15 minutes after the recipient blood supply to the graft is established,the graft becomes pale,and stops functioning.Microscopic analysis of the failed graft shows death of cells due to lack of blood flow ("ischemic necrosis").What is the most likely cause of this graft failure?