Exam 6: Lymphocyte-Development

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -A segment that encodes Ig domains that form part of the antigen-binding region of an Ig molecule

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Question 1

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A
One variable (V)gene segment,from as many as 45 possible V gene segments,is used in each functional Ig heavy chain gene.This V gene segment encodes an Ig domain that includes complementarity-determining regions (CDRs)1 and 2 of the antigen-binding region of the heavy chain.

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -A type of gene segment involved in somatic recombination events in Ig heavy chain and light chain as well as TCR a and b chain gene loci

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Question 2

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Verified

C
Joining (J)segments are found in all antigen receptor loci.In the first somatic recombination event in Ig heavy chain and TCR $\beta$ chain loci,J segments are joined to D segments.In the only somatic recombination event in the Ig light chain and the TCR $\alpha$ chain loci,J segments are joined to V segments.

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -Encodes the isotype of antibodies made by naive B cells

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Question 3

Correct Answer:

Verified

D
Naive B cells produce IgM and IgD antibody isotypes.The IgM isotype is a characteristic of the heavy chain constant region,encoded by the C $\mu$ gene segment.

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)? -Stem cell to committed B or T lineage precursor

(Multiple Choice)

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Question 4

Which of the following statements about negative selection during lymphocyte development is most accurate?

(Multiple Choice)

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Question 5

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)? -Pro-B cell to pre-B cell

(Multiple Choice)

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Question 6

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)? -CD4+CD8+ thymocyte to single positive CD8+ thymocyte

(Multiple Choice)

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Question 7

Which of the following is NOT a required step in B and T lymphocyte maturation?

(Multiple Choice)

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Question 8

Which of the following is NOT a property of the V(D)J recombinase?

(Multiple Choice)

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Question 9

Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?

(Multiple Choice)

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Question 10

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -This type of gene segment that encodes part of the third complementarity determining region (CDR3)of Ig heavy chains and TCR b chains but not Ig light chains or TCR a chains

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Question 11

Showing 1 - 11 of 11

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -A segment that encodes Ig domains that form part of the antigen-binding region of an Ig molecule

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -Encodes the isotype of antibodies made by naive B cells

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)? -Stem cell to committed B or T lineage precursor

Which of the following statements about negative selection during lymphocyte development is most accurate?

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)? -Pro-B cell to pre-B cell

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F)? -CD4+CD8+ thymocyte to single positive CD8+ thymocyte

Which of the following is NOT a required step in B and T lymphocyte maturation?

Which of the following is NOT a property of the V(D)J recombinase?

Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?

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