Exam 10: Hypersensitivity-And-Autoimmunity

The most commonly identified alleles that are associated with risk for autoimmune diseases encode which type of the following proteins?

Which of the following statements about immune complex-mediated diseases is NOT true?

Which type of hypersensitivity disease is caused by deposition of antigen-antibody complexes in blood vessel walls?

For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. ) -A 5-year-old girl is taken to the emergency department with lethargy ,confusion ,vomiting,abdominal pain ,and flushed skin that is warm to the touch.Respirations are fast and shallow and emanate a strong,fruity odor.The mother notes that the child has been excessively thirsty over the past week and that she began wetting her bed during naps.Urine dipstick testing reveals markedly elevated levels of glucose and ketones.

All of the following are effector mechanisms of antibody-mediated disease EXCEPT:

For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. ) -A 60-year-old man is evaluated for shortness of breath,lightheadedness,diarrhea,abdominal pain,and tingling in his fingers and toes.A blood smear from the patient is shown in the figure.Antibodies to intrinsic factor are detected in his serum.

For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. ) -A 23-year-old medical student is taken to the emergency department because of diffuse facial erythema (redness),tightness of the chest,and difficulty breathing.He reports that the symptoms began shortly after he ate a shellfish dinner at a nearby Thai restaurant.On physical examination,he appears to be in acute distress with elevated heart rate and respiratory rate and a dangerously low blood pressure.He is treated with epinephrine.

The figure shows routine histologic and immunofluorescence images of a kidney biopsy specimen taken from a 53-year-old man with acute-onset renal failure and hemoptysis (coughing up blood).The histologic section is notable for glomerular inflammation in a crescentic distribution.Staining,using fluorescently tagged anti-IgG antibody,shows linear deposits of IgG along the glomerular basement membrane.Urinalysis is positive for moderate proteinuria and red cell casts.A chest radiograph shows pulmonary infiltrates.Which of the following is the most likely diagnosis?

In which of the following disorders is the underlying pathogenic mechanism NOT due to antibody-mediated damage to cells or tissues?

For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. ) -A 29-year-old woman gives birth to an infant who is lethargic,jaundiced,and severely anemic and has an enlarged liver and spleen.The mother is RhD negative and the father is homozygous RhD positive.This is their second child.

Which of the following is NOT associated with increased relative risk of developing systemic lupus erythematosus?