Question 1

One difference between cancer cells and normal cells is that cancer cells

Accepted Answer

A)  are unable to synthesise DNA. 
B)  are arrested at the S phase of the cell cycle. 
C)  continue to divide even when they are tightly packed together. 
D)  cannot function properly because they are affected by density-dependent inhibition. 
A)  are unable to synthesise DNA. 
B)  are arrested at the S phase of the cell cycle. 
C)  continue to divide even when they are tightly packed together. 
D)  cannot function properly because they are affected by density-dependent inhibition. C

Question 2

What would you expect to happen if MPF (maturation-promoting factor) is introduced into immature frog oocytes that are arrested in G2?

Accepted Answer

A)  The cells would remain arrested in G2. 
B)  The cells would enter G0. 
C)  The cells would enter mitosis. 
D)  The cells would begin DNA synthesis. 
A)  The cells would remain arrested in G2. 
B)  The cells would enter G0. 
C)  The cells would enter mitosis. 
D)  The cells would begin DNA synthesis. C

Question 3

Eukaryotic chromosomes are composed of which of the following macromolecules?

Accepted Answer

A)  DNA and RNA 
B)  DNA only 
C)  DNA and proteins 
D)  DNA and phospholipids 
A)  DNA and RNA 
B)  DNA only 
C)  DNA and proteins 
D)  DNA and phospholipids C

Question 4

In a diploid cell with 5 chromosome pairs (2n = 10), how many sister chromatids will be found in a nucleus at prophase of mitosis?

Accepted Answer

A)  5 
B)  10 
C)  20 
D)  40 
A)  5 
B)  10 
C)  20 
D)  40

Question 5

During which phase of mitosis do the chromatids become chromosomes?

Accepted Answer

A)  telophase 
B)  anaphase 
C)  prophase 
D)  metaphase 
A)  telophase 
B)  anaphase 
C)  prophase 
D)  metaphase

Question 6

What two components constitute an active MPF?

Accepted Answer

A)  a growth factor and mitotic factor 
B)  ATP synthetase and a protease 
C)  cyclin and tubulin 
D)  cyclin and a cyclin-dependent kinase 
A)  a growth factor and mitotic factor 
B)  ATP synthetase and a protease 
C)  cyclin and tubulin 
D)  cyclin and a cyclin-dependent kinase

Question 7

A group of cells is assayed for DNA content immediately following mitosis and is found to have an average of 8 picograms of DNA per nucleus. How many picograms of DNA would be found in a nucleus at prophase of mitosis?

Accepted Answer

A)  4 
B)  8 
C)  16 
D)  24 
A)  4 
B)  8 
C)  16 
D)  24

Question 8

FtsZ is a bacterial cytoskeletal protein that forms a contractile ring involved in binary fission. Its function is analogous to ________.

Accepted Answer

A)  the cleavage furrow of eukaryotic animal cells 
B)  the cell plate of eukaryotic plant cells 
C)  the mitotic spindle of eukaryotic cells 
D)  the microtubule-organising centre of eukaryotic cells 
A)  the cleavage furrow of eukaryotic animal cells 
B)  the cell plate of eukaryotic plant cells 
C)  the mitotic spindle of eukaryotic cells 
D)  the microtubule-organising centre of eukaryotic cells

Question 9

Once a cell enters mitosis, the molecules that activate division must be turned off. What happens to MPF during mitosis?

Accepted Answer

A)  It is completely degraded. 
B)  It is phosphorylated by a Cdk, which inactivates it. 
C)  The cyclin component of MPF is degraded. 
D)  The Cdk component of MPF is degraded. 
A)  It is completely degraded. 
B)  It is phosphorylated by a Cdk, which inactivates it. 
C)  The cyclin component of MPF is degraded. 
D)  The Cdk component of MPF is degraded.

Question 10

Cell A has half as much DNA as cells B, C, and D in a mitotically active tissue. Cell A is most likely in

Accepted Answer

A)  G1. 
B)  G2. 
C)  prophase. 
D)  metaphase. 
A)  G1. 
B)  G2. 
C)  prophase. 
D)  metaphase.

Question 11

Through a microscope, you can see a cell plate beginning to develop across the middle of a cell and nuclei forming on either side of the cell plate. This cell is most likely ________.

Accepted Answer

A)  an animal cell in the process of cytokinesis 
B)  an animal cell in anaphase of mitosis 
C)  a plant cell in the process of cytokinesis 
D)  a plant cell in metaphase of mitosis 
A)  an animal cell in the process of cytokinesis 
B)  an animal cell in anaphase of mitosis 
C)  a plant cell in the process of cytokinesis 
D)  a plant cell in metaphase of mitosis

Question 12

The unlettered circle at the top of the figure shows a diploid nucleus with four chromosomes that have not yet replicated. There are two pairs of homologous chromosomes, one long and the other short. One haploid set is black, and the other is grey. The circles labelled A to E show various combinations of these chromosomes.  
-
What is the correct chromosomal condition at prometaphase of mitosis?

Accepted Answer

A)  B 
B)  C 
C)  D 
D)  E 
A)  B 
B)  C 
C)  D 
D)  E

Question 13

The drug cytochalasin B blocks the function of actin. Which of the following aspects of the animal cell cycle would be most disrupted by cytochalasin B?

Accepted Answer

A)  spindle formation 
B)  spindle attachment to kinetochores 
C)  cell elongation during anaphase 
D)  cleavage furrow formation and cytokinesis 
A)  spindle formation 
B)  spindle attachment to kinetochores 
C)  cell elongation during anaphase 
D)  cleavage furrow formation and cytokinesis

Question 14

-In the figure, G1 is represented by which numbered part(s) of the cycle?

Accepted Answer

A)  I and V 
B)  II 
C)  III 
D)  IV 
A)  I and V 
B)  II 
C)  III 
D)  IV

Question 15

- In the figure, which number represents DNA synthesis?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 16

At what stage of the cell cycle is the cyclin component of MPF destroyed?

Accepted Answer

A)  in late G1 
B)  at mid-S phase 
C)  in early G2 
D)  in late M 
A)  in late G1 
B)  at mid-S phase 
C)  in early G2 
D)  in late M

Question 17

Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to

Accepted Answer

A)  disruption of mitotic spindle formation. 
B)  suppression of cyclin production. 
C)  myosin denaturation and inhibition of cleavage furrow formation. 
D)  inhibition of DNA synthesis. 
A)  disruption of mitotic spindle formation. 
B)  suppression of cyclin production. 
C)  myosin denaturation and inhibition of cleavage furrow formation. 
D)  inhibition of DNA synthesis.

Question 18

G1 is associated with which of the following cellular events?

Accepted Answer

A)  normal growth and cell function 
B)  DNA replication 
C)  the beginning of mitosis 
D)  break down of the nuclear membrane 
A)  normal growth and cell function 
B)  DNA replication 
C)  the beginning of mitosis 
D)  break down of the nuclear membrane

Question 19

How is plant cell cytokinesis different from animal cell cytokinesis?

Accepted Answer

A)  The contractile filaments found in plant cells are structures composed of carbohydrates; the cleavage furrow in animal cells is composed of contractile proteins. 
B)  Plant cells deposit vesicles containing cell wall building blocks on the metaphase plate; animal cells form a cleavage furrow. 
C)  The structural proteins of plant cells separate the two cells; in animal cells, a cell membrane separates the two daughter cells. 
D)  Plant cells divide after metaphase but before anaphase; animal cells divide after anaphase. 
A)  The contractile filaments found in plant cells are structures composed of carbohydrates; the cleavage furrow in animal cells is composed of contractile proteins. 
B)  Plant cells deposit vesicles containing cell wall building blocks on the metaphase plate; animal cells form a cleavage furrow. 
C)  The structural proteins of plant cells separate the two cells; in animal cells, a cell membrane separates the two daughter cells. 
D)  Plant cells divide after metaphase but before anaphase; animal cells divide after anaphase.

Question 20

- at which of the numbered regions would you expect to find cells at metaphase?

Accepted Answer

A)  II and IV 
B)  II only 
C)  III only 
D)  IV only 
A)  II and IV 
B)  II only 
C)  III only 
D)  IV only

Exam 12: The Cell Cycle

One difference between cancer cells and normal cells is that cancer cells

What would you expect to happen if MPF (maturation-promoting factor) is introduced into immature frog oocytes that are arrested in G2?

Eukaryotic chromosomes are composed of which of the following macromolecules?

In a diploid cell with 5 chromosome pairs (2n = 10), how many sister chromatids will be found in a nucleus at prophase of mitosis?

During which phase of mitosis do the chromatids become chromosomes?

What two components constitute an active MPF?

A group of cells is assayed for DNA content immediately following mitosis and is found to have an average of 8 picograms of DNA per nucleus. How many picograms of DNA would be found in a nucleus at prophase of mitosis?

FtsZ is a bacterial cytoskeletal protein that forms a contractile ring involved in binary fission. Its function is analogous to ________.

Once a cell enters mitosis, the molecules that activate division must be turned off. What happens to MPF during mitosis?

Cell A has half as much DNA as cells B, C, and D in a mitotically active tissue. Cell A is most likely in

Through a microscope, you can see a cell plate beginning to develop across the middle of a cell and nuclei forming on either side of the cell plate. This cell is most likely ________.

The drug cytochalasin B blocks the function of actin. Which of the following aspects of the animal cell cycle would be most disrupted by cytochalasin B?

-In the figure, G1 is represented by which numbered part(s) of the cycle?

- In the figure, which number represents DNA synthesis?

At what stage of the cell cycle is the cyclin component of MPF destroyed?

Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to

G1 is associated with which of the following cellular events?

How is plant cell cytokinesis different from animal cell cytokinesis?

- at which of the numbered regions would you expect to find cells at metaphase?

Evolution, the Themes of Biology, and Scientific Inquiry

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The Structure and Function of Large Biological Molecules

A Tour of the Cell

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The Molecular Basis of Inheritance

Gene Expression: From Gene to Protein

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What would you expect to happen if MPF (maturation-promoting factor) is introduced into immature frog oocytes that are arrested in G₂?