Question 1

Provide the reagents necessary to prepare 1-bromo-3-isobutylbenzene benzene.

Accepted Answer

1. @#IMG-DLM& 2. Br₂

Question 2

Provide the structure of the major products formed in the following reaction sequence.

Accepted Answer

The answer of Provide the structure of the major products...

Question 3

Provide the reagents necessary to carry out the following conversion.

Accepted Answer

1. CH₃CH₂Cl/AlCl₃ 2. Fu

Question 4

Provide the structure of the major product when anisole is treated with the following reagents:

Accepted Answer

1. Br₂, FeB

Question 5

Which one of the following reactions is most likely to give a polysubstituted product?

Accepted Answer

A)  Friedel-Crafts alkylation 
B)  Friedel-Crafts acylation 
C)  Nitration 
D)  Sulfonation 
E)  Halogenation 
A)  Friedel-Crafts alkylation 
B)  Friedel-Crafts acylation 
C)  Nitration 
D)  Sulfonation 
E)  Halogenation

Question 6

Which of the following compounds will not undergo nucleophilic aromatic substitution?

Accepted Answer

A)  1-chloro-2,4-dinitrobenzene 
B)  1-bromo-4-nitrobenzene 
C)  o-chloronitrobenzene 
D)  m-chloronitrobenzene 
E)  p-chloronitrobenzene 
A)  1-chloro-2,4-dinitrobenzene 
B)  1-bromo-4-nitrobenzene 
C)  o-chloronitrobenzene 
D)  m-chloronitrobenzene 
E)  p-chloronitrobenzene

Question 7

Provide the reagents necessary to carry out the following conversion.

Accepted Answer

1. (CH₃)₂CHCl /AlCl₃ 2.

Question 8

Aryl and vinyl halides cannot be used in the Friedel-Crafts alkylation reaction, because they do not __________.

Accepted Answer

form stabl

Question 9

Provide the reagents necessary to carry out the following conversion.

Accepted Answer

1. (CH₃)<

Question 10

Predict the structure of the product for the following reaction.

Accepted Answer

The answer of Predict the structure of the product for...

Question 11

The electrophile in the sulfonation reaction of benzene is:

Accepted Answer

A)  SO2+ 
B)  H2SO4 
C)  SO3+ 
D)  H2SO3 
E)  SO3 
A)  SO2+ 
B)  H2SO4 
C)  SO3+ 
D)  H2SO3 
E)  SO3

Question 12

Predict the major product for the following reaction.

Accepted Answer

The answer of Predict the major product for the following...

Question 13

Which of the following substituents will direct the incoming group to the ortho/para position during electrophilic aromatic substitution?

Accepted Answer

A)  -NO2 
B)  -CF3 
C)  -Br 
D)  -COOCH3 
E)  none of these 
A)  -NO2 
B)  -CF3 
C)  -Br 
D)  -COOCH3 
E)  none of these

Question 14

Predict the major product for the following reaction.

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
E)  none of these 
A)  I 
B)  II 
C)  III 
D)  IV 
E)  none of these

Question 15

Predict the major product for the following reaction.

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
E)  no reaction 
A)  I 
B)  II 
C)  III 
D)  IV 
E)  no reaction

Question 16

Provide the reagent(s) necessary to carry out the following conversion.

Accepted Answer

The answer of Provide the reagent(s) necessary to carry out...

Question 17

Provide the reagents necessary to carry out the following conversion.

Accepted Answer

1. CH₃CH₂Cl/

Question 18

Provide the curved arrow mechanism for the following reaction.

Accepted Answer

The answer of Provide the curved arrow mechanism for the...

Question 19

Predict the major product for the following reaction.

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
E)  V 
A)  I 
B)  II 
C)  III 
D)  IV 
E)  V

Question 20

Predict the major product for the following reaction.

Accepted Answer

The answer of Predict the major product for the following...

Exam 19: Aromatic Substitution Reactions

Provide the reagents necessary to prepare 1-bromo-3-isobutylbenzene benzene.

Provide the structure of the major products formed in the following reaction sequence.

Provide the reagents necessary to carry out the following conversion.

Provide the structure of the major product when anisole is treated with the following reagents:

Which one of the following reactions is most likely to give a polysubstituted product?

Which of the following compounds will not undergo nucleophilic aromatic substitution?

Provide the reagents necessary to carry out the following conversion.

Aryl and vinyl halides cannot be used in the Friedel-Crafts alkylation reaction, because they do not __________.

Provide the reagents necessary to carry out the following conversion.

Predict the structure of the product for the following reaction.

The electrophile in the sulfonation reaction of benzene is:

Predict the major product for the following reaction.

Which of the following substituents will direct the incoming group to the ortho/para position during electrophilic aromatic substitution?

Predict the major product for the following reaction.

Predict the major product for the following reaction.

Provide the reagent(s) necessary to carry out the following conversion.

Provide the reagents necessary to carry out the following conversion.

Provide the curved arrow mechanism for the following reaction.

Predict the major product for the following reaction.

Predict the major product for the following reaction.

A Review of General Chemistry: Electrons, Bonds, and Molecular Properties

Molecular Representations

Acids and Bases

Alkanes and Cycloalkanes

Stereoisomerism

Chemical Reactivity and Mechanisms

Substitution Reactions

Alkenes: Structure and Preparation Via Elimination Reactions

Addition Reactions of Alkenes

Alkynes

Radical Reactions

Synthesis

Alcohols and Phenols

Ethers and Epoxides; Thiols and Sulfides

Infrared Spectroscopy and Mass Spectrometry

Nuclear Magnetic Resonance Spectroscopy

Conjugated Pi Systems and Pericyclic Reactions

Aromatic Compounds

Aldehydes and Ketones

Carboxylic Acids and Their Derivatives

Alpha Carbon Chemistry: Enols and Enolates

Amines

Carbohydrates

Amino Acids, Peptides, and Proteins

Lipids

Synthetic Polymers

Filters