Question 1

Which of the following is NOT a rule for HLA nomenclature?

Accepted Answer

A)  Capital letters indicate a specific gene. 
B)  All class II genes are prefixed by the letter D 
C)  The allele group is designated by the fourth numeric field. 
D)  The second numeric field defines the specific allele protein. 
A)  Capital letters indicate a specific gene. 
B)  All class II genes are prefixed by the letter D 
C)  The allele group is designated by the fourth numeric field. 
D)  The second numeric field defines the specific allele protein.

Question 2

What is the main purpose of crossmatching before transplantation?

Accepted Answer

A)  To identify antibody in the potential donor to antigen present on recipient cells 
B)  To identify antibody in the serum of the potential recipient to antigens present on donor tissues 
C)  To identify antigen in the recipient cells to antibody present in donor serum 
D)  To identify antigen present on donor tissues to antibody present in recipient serum 
A)  To identify antibody in the potential donor to antigen present on recipient cells 
B)  To identify antibody in the serum of the potential recipient to antigens present on donor tissues 
C)  To identify antigen in the recipient cells to antibody present in donor serum 
D)  To identify antigen present on donor tissues to antibody present in recipient serum

Question 3

What is the purpose of washing the cells after the initial cell-serum incubation in the Amos-modified antibody screen procedure?

Accepted Answer

A)  To identify previously undefined alleles 
B)  To identify antibodies in the serum of the donor 
C)  To remove aggregated immunoglobulin in the serum 
D)  None of the above 
A)  To identify previously undefined alleles 
B)  To identify antibodies in the serum of the donor 
C)  To remove aggregated immunoglobulin in the serum 
D)  None of the above

Question 4

Recipient lymphocytotoxic HLA-antibody to donor antigens is associated with:

Accepted Answer

A)  accelerated graft rejection. 
B)  platelet refractoriness. 
C)  respiratory distress. 
D)  both A and B. 
A)  accelerated graft rejection. 
B)  platelet refractoriness. 
C)  respiratory distress. 
D)  both A and B.

Question 5

What is the linkage disequilibrium in reference to the HLA antigens?

Accepted Answer

A)  Occurrence of HLA genes more frequently in the same haplotype than would be expected by chance alone 
B)  Displacement of HLA genes on different chromosomes 
C)  Occurrence of HLA genes less frequently in the same haplotype than would be expected by chance alone 
D)  Crossover of HLA genes 
A)  Occurrence of HLA genes more frequently in the same haplotype than would be expected by chance alone 
B)  Displacement of HLA genes on different chromosomes 
C)  Occurrence of HLA genes less frequently in the same haplotype than would be expected by chance alone 
D)  Crossover of HLA genes

Question 6

What does the "R" signify in the HLA-DR locus?

Accepted Answer

A)  Recessive gene 
B)  Red cell predominance 
C)  RNA 
D)  Subregion of D 
A)  Recessive gene 
B)  Red cell predominance 
C)  RNA 
D)  Subregion of D

Question 7

The HLA-A locus antigens A2, A23, A24, and A28 make up the:

Accepted Answer

A)  A4-CREG 
B)  A3-CREG 
C)  A2-CREG 
D)  A8-CREG 
A)  A4-CREG 
B)  A3-CREG 
C)  A2-CREG 
D)  A8-CREG

Question 8

Why are monoclonal antibodies able to detect a broad range of epitopes?

Accepted Answer

A)  They are derived through alloimmunization. 
B)  They are derived through xenoimmunization. 
C)  They have both IgM and IgG specificity. 
D)  None of the above 
A)  They are derived through alloimmunization. 
B)  They are derived through xenoimmunization. 
C)  They have both IgM and IgG specificity. 
D)  None of the above

Question 9

When the entire set of A, B, C, DR, DQ, and DP antigens are located on one chromosome, it is called a:

Accepted Answer

A)  phenotype. 
B)  genotype. 
C)  haplotype. 
D)  karyotype. 
A)  phenotype. 
B)  genotype. 
C)  haplotype. 
D)  karyotype.

Question 10

HLA testing is useful in what other area of study?

Accepted Answer

A)  Paternity testing 
B)  Disease correlation 
C)  Anthropology 
D)  All of the above 
A)  Paternity testing 
B)  Disease correlation 
C)  Anthropology 
D)  All of the above

Question 11

What is meant by the term public as applied to HLA antibodies?

Accepted Answer

A)  Antibodies that detect a single HLA gene product 
B)  Binding to an epitope unique to one HLA gene product 
C)  Binding to epitopes shared by more than one HLA gene product 
D)  All of the above 
A)  Antibodies that detect a single HLA gene product 
B)  Binding to an epitope unique to one HLA gene product 
C)  Binding to epitopes shared by more than one HLA gene product 
D)  All of the above

Which of the following is NOT a rule for HLA nomenclature?

What is the main purpose of crossmatching before transplantation?

What is the purpose of washing the cells after the initial cell-serum incubation in the Amos-modified antibody screen procedure?

Recipient lymphocytotoxic HLA-antibody to donor antigens is associated with:

What is the linkage disequilibrium in reference to the HLA antigens?

What does the "R" signify in the HLA-DR locus?

The HLA-A locus antigens A2, A23, A24, and A28 make up the:

Why are monoclonal antibodies able to detect a broad range of epitopes?

When the entire set of A, B, C, DR, DQ, and DP antigens are located on one chromosome, it is called a:

HLA testing is useful in what other area of study?

What is meant by the term public as applied to HLA antibodies?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters

Exam 23: The Hla System

Which of the following is NOT a rule for HLA nomenclature?

What is the main purpose of crossmatching before transplantation?

What is the purpose of washing the cells after the initial cell-serum incubation in the Amos-modified antibody screen procedure?

Recipient lymphocytotoxic HLA-antibody to donor antigens is associated with:

What is the linkage disequilibrium in reference to the HLA antigens?

What does the "R" signify in the HLA-DR locus?

The HLA-A locus antigens A2, A23, A24, and A28 make up the:

Why are monoclonal antibodies able to detect a broad range of epitopes?

When the entire set of A, B, C, DR, DQ, and DP antigens are located on one chromosome, it is called a:

HLA testing is useful in what other area of study?

What is meant by the term public as applied to HLA antibodies?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Apheresis

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Filters