Exam 15: Regulation of Gene Expression in Bacteria and Bacteriophages

A point mutation changes a codon from UCG to UAG. What will happen to the resulting polypeptide?

LINEs and SINEs are repetitive sequences in humans that are also retrotransposons that can insert into genes and cause disease.

Base analogs may cause mutations because

Barbara McClintock's contemporaries were hostile to her discovery of mobile genetic elements because

Describe how the Ames test is used to determine whether a particular chemical is mutagenic.

In order for the Ds mutations in corn to be stable,

A mutation during DNA replication causes a G to be inserted after the first base of the codon for tryptophan. How will this affect the growing polypeptide chain?

Dissociation elements (Ds) in plants are examples of

Barbara McClintock discovered that a controlling element was responsible for the mutant spotted phenotype (purple spots on white) in corn kernels. Explain how this works.

What kind of mutation detection procedure can be used to detect the white eye mutation in Drosophila?

A tumor suppressor gene is cloned and mutagenized in vitro, then injected into mouse embryos to create knockout mice. How could you identify the heterozygous knockout mice and create mice susceptible to tumors?

Xeroderma pigmentosum is a human genetic disease caused by

The DNA polymerase proofreading mechanism maintains a low mutation rate in eukaryotic genes.

A transposon is

Somatic mutations may be inherited by the next generation.

Composite transposons contain a central region with genes and repeated sequences at their ends but do not terminate with IS elements.

How does an intercalating agent such as ethidium bromide cause mutations?

Spontaneous mutation rates are greatly reduced by

Explain what a mutator gene is and give an example.

What is conservative transposition?