Exam 3: Neurogenesis and Migration

In the developing neural tube, migrating postmitotic cells shinny outward on _______ toward their destination.

Cell adhesion molecules (CAMs) play an important role in neural crest cell migration. Describe how migrating neural crest cells change their expression of two adhesion molecules, and how this change influences their movement at each of the following points along their migration: initially leaving the neural tube, migrating along the pathway toward their target, and settling down at their final target.

If adult neurogenesis occurs in a certain region of the brain, why might that area not continue to grow larger?

When researchers wanted to know whether mitotic lineage played a role in whether vertebrate neural cells develop into neurons or glia, they infected a single cell with the reporter gene lacZ, which allowed them to track every cell that descended from that one original parent cell. They found that the single infected cell ended up dividing to produce many different types of cells. What do these results suggest?

If BrDU is injected into an adult rat, and one month later, the rat's brain is examined and found to have BrDU in the nucleus of neurons in the dentate gyrus. What can be concluded about the BrDU-stained neurons?

In adults, newly born interneurons in the olfactory bulb arise from cells in the

In the developing cerebral cortex, the _______ is the layer of postmitotic cells that expands to form cortical layers II-IV.

Neurons that develop from the ganglionic eminences migrate _______ along glia and become _______.

In the developing cerebral cortex, the cortical intermediate zone eventually forms what is called the white matter of the brain. Explain why the white matter appears white.

The tangled threads of chromosomes that are in the process of separating are called

In cerebellar development, the cell bodies of granule neurons migrate along _______ to settle into their adult placement in the _______ granule layer.

In the cerebral cortex, how does cell division in the ventricular zone differ from that in the subventricular zone?

To determine what specific cells will end up migrating to the hypothalamus from a point in development just after the telencephalon has formed, the best experimental design would be to use immunohistochemistry directed at

GnRH-releasing neurons in the hypothalamus migrate during development from the

Abnormal cerebellum development characterized by a missing granule cell layer results from a mutation in which gene?