Question 1

Most Ran in the nucleus is bound to ___, and most Ran in the cytosol is bound to ___.

Accepted Answer

A)  GTP; GDP 
B)  GDP; GTP 
C)  GDP; GDP 
D)  GDP; ATP 
E)  ADP; GTP 
A)  GTP; GDP 
B)  GDP; GTP 
C)  GDP; GDP 
D)  GDP; ATP 
E)  ADP; GTP A

Question 2

What is the region immediately upstream from the starting site for RNA polymerization called?

Accepted Answer

A)  promoter 
B)  enhancer 
C)  initiator 
D)  consensus sequence 
E)  TF binding site 
A)  promoter 
B)  enhancer 
C)  initiator 
D)  consensus sequence 
E)  TF binding site A

Question 3

In eukaryotes, mRNAs are synthesized in the cell ______, whereas most translation occurs in
The ______.

Accepted Answer

A)  nucleus, nucleosome. 
B)  nucleus, cytosol. 
C)  cytosol, nucleosome. 
D)  cytosol, nucleus. 
E)  nucleosome, cytosol. 
A)  nucleus, nucleosome. 
B)  nucleus, cytosol. 
C)  cytosol, nucleosome. 
D)  cytosol, nucleus. 
E)  nucleosome, cytosol. B

Question 4

Drugs important to AIDS therapy commonly attack retroviruses, since humans lack ___

Accepted Answer

reverse tr

Question 5

With differential splicing, humans can produce approximately ___ as many proteins as their ___ genes.

Accepted Answer

The answer of With differential splicing, humans can produce approximately...

Question 6

Which of the following allows a gene to give more than one viable protein product?

Accepted Answer

A)  exon suppression 
B)  alternative splicing 
C)  use of RNA interference 
D)  frame shift mutations 
E)  action of the decapping enzyme 
A)  exon suppression 
B)  alternative splicing 
C)  use of RNA interference 
D)  frame shift mutations 
E)  action of the decapping enzyme

Question 7

Ran

Accepted Answer

A)  has GTPase activity 
B)  can be found in both the nucleus and the cytosol 
C)  can be bound to both GTP and GDP 
D)  binds importin and exportin 
E)  all of the above 
A)  has GTPase activity 
B)  can be found in both the nucleus and the cytosol 
C)  can be bound to both GTP and GDP 
D)  binds importin and exportin 
E)  all of the above

Question 8

Amanatin at low concentrations would be most expected to disrupt

Accepted Answer

A)  translation via disruption of the structure of the ribosome 
B)  translation via transfer of amino acids to the ribosome 
C)  transcription in prokaryotes 
D)  transcription of rRNAs 
E)  transcription of mRNAs 
A)  translation via disruption of the structure of the ribosome 
B)  translation via transfer of amino acids to the ribosome 
C)  transcription in prokaryotes 
D)  transcription of rRNAs 
E)  transcription of mRNAs

Question 9

The ___ regulates passage of molecules into and out of the nucleus.

Accepted Answer

nuclear po

Question 10

Which of the following is responsible for RNA splicing?

Accepted Answer

A)  rRNA 
B)  miRNA 
C)  tRNA 
D)  siRNA 
E)  snRNA 
A)  rRNA 
B)  miRNA 
C)  tRNA 
D)  siRNA 
E)  snRNA

Question 11

Which of the following modifications occurs to all eukaryotic mRNA?

Accepted Answer

A)  addition of a poly(
A)  tail to the 3' end of the molecule 
B)  hydrolysis of the terminal phosphate from the 5' triphosphate end of the molecule 
C)  addition of GMP to the 5'end via a 5' to 5'linkage 
D)  methylation of the 2'hydroxyl on the first nucleotide of the molecule 
E)  all of the above 
A)  addition of a poly(
A)  tail to the 3' end of the molecule 
B)  hydrolysis of the terminal phosphate from the 5' triphosphate end of the molecule 
C)  addition of GMP to the 5'end via a 5' to 5'linkage 
D)  methylation of the 2'hydroxyl on the first nucleotide of the molecule 
E)  all of the above

Question 12

Which is involved in differential splicing?
I. exon skipping
II. RNase P endonuclease activity
III. alternative donor sites
IV. multiple poly(A) signals

Accepted Answer

A)  I and II 
B)  I and IV 
C)  I, III and IV 
D)  I only 
E)  III only 
A)  I and II 
B)  I and IV 
C)  I, III and IV 
D)  I only 
E)  III only

Question 13

In prokaryotic transcription, what must be released for the switch from initiation to elongation to occur?

Accepted Answer

A)  TFIIB 
B)  ADP following phosphorylation of the RNA polymerase C-terminal domain 
C)  regulatory subunit bound to the C-terminal domain 
D)  $\sigma$ subunit 
E)  the TATA-binding protein 
A)  TFIIB 
B)  ADP following phosphorylation of the RNA polymerase C-terminal domain 
C)  regulatory subunit bound to the C-terminal domain 
D)  $\sigma$ subunit 
E)  the TATA-binding protein

Question 14

Separation of DNA into a single stranded region around RNA polymerase creates _____.

Accepted Answer

A)  hybridized DNA 
B)  a transcription bubble 
C)  Z-DNA 
D)  DNA bound to single stranded binding proteins 
E)  none of the above 
A)  hybridized DNA 
B)  a transcription bubble 
C)  Z-DNA 
D)  DNA bound to single stranded binding proteins 
E)  none of the above

Question 15

What protein/RNA complex is responsible for the removal of introns?

Accepted Answer

A)  intronase 
B)  RNA processing complex 
C)  spliceosome 
D)  ribozyme 
E)  none of the above 
A)  intronase 
B)  RNA processing complex 
C)  spliceosome 
D)  ribozyme 
E)  none of the above

Question 16

TFIIB

Accepted Answer

A)  is important to the activity of RNA polymerase II 
B)  binds to TBP during initiation of transcription 
C)  orients the polymerase complex, dictates the travel direction of the enzyme 
D)  dictates the strand to be copied 
E)  all of the above 
A)  is important to the activity of RNA polymerase II 
B)  binds to TBP during initiation of transcription 
C)  orients the polymerase complex, dictates the travel direction of the enzyme 
D)  dictates the strand to be copied 
E)  all of the above

Question 17

Nuclear pores are dynamic, varying with

Accepted Answer

A)  type of cell 
B)  organism development 
C)  cell life cycle stage 
D)  significant cell growth 
E)  all of the above 
A)  type of cell 
B)  organism development 
C)  cell life cycle stage 
D)  significant cell growth 
E)  all of the above

Question 18

Which of the following best describes the nucleic acid complex formed during RNA polymerization?

Accepted Answer

A)  two DNA-RNA hybrids since both DNA strands are transcribed simultaneously 
B)  one DNA-RNA hybrid and one single stranded DNA 
C)  one DNA-RNA hybrid with the other DNA strand bound to an RNA molecule on
RNA polymerase 
D)  there is no interaction between the growing RNA and the DNA 
E)  none of the above 
A)  two DNA-RNA hybrids since both DNA strands are transcribed simultaneously 
B)  one DNA-RNA hybrid and one single stranded DNA 
C)  one DNA-RNA hybrid with the other DNA strand bound to an RNA molecule on
RNA polymerase 
D)  there is no interaction between the growing RNA and the DNA 
E)  none of the above

Question 19

The drawing below is needed to answer the following two questions  
-This molecule is found in

Accepted Answer

A)  nascent mRNA 
B)  tRNA 
C)  rRNA 
D)  mature mRNA 
E)  all of the above 
A)  nascent mRNA 
B)  tRNA 
C)  rRNA 
D)  mature mRNA 
E)  all of the above

Question 20

Cargo to be imported into the nucleus through the NPC binds to is associated with

Accepted Answer

A)  GTP 
B)  Ran-GDP 
C)  intranuclear filaments 
D)  importin 
E)  exportin 
A)  GTP 
B)  Ran-GDP 
C)  intranuclear filaments 
D)  importin 
E)  exportin

Exam 15: Rna Synthesis

Most Ran in the nucleus is bound to ___, and most Ran in the cytosol is bound to ___.

What is the region immediately upstream from the starting site for RNA polymerization called?

In eukaryotes, mRNAs are synthesized in the cell ______, whereas most translation occurs in The ______.

Drugs important to AIDS therapy commonly attack retroviruses, since humans lack ___

With differential splicing, humans can produce approximately ___ as many proteins as their ___ genes.

Which of the following allows a gene to give more than one viable protein product?

Ran

Amanatin at low concentrations would be most expected to disrupt

The ___ regulates passage of molecules into and out of the nucleus.

Which of the following is responsible for RNA splicing?

Which of the following modifications occurs to all eukaryotic mRNA?

Which is involved in differential splicing? I. exon skipping II. RNase P endonuclease activity III. alternative donor sites IV. multiple poly(A) signals

In prokaryotic transcription, what must be released for the switch from initiation to elongation to occur?

Separation of DNA into a single stranded region around RNA polymerase creates _____.

What protein/RNA complex is responsible for the removal of introns?

TFIIB

Nuclear pores are dynamic, varying with

Which of the following best describes the nucleic acid complex formed during RNA polymerization?

The drawing below is needed to answer the following two questions -This molecule is found in

Cargo to be imported into the nucleus through the NPC binds to is associated with

The Chemical Foundations of Biochemistry

Nucleic Acids

Proteins I

Proteins Iienzymes

Membranes and an Introduction to Signal Transduction

Carbohydrates I

The Common Catabolic Pathway

Carbohydrates II

Lipids I

Lipids II

Amine Metabolism

Metabolism Integration

Nucleotide Deoxynucleotide Metabolism

Dna Replication, Damage and Repair

Protein

Control of Gene

Determination of Macromolecular Structure

Allosterism and Receptor-Ligand

Designer Proteins and Protein Folding

Biomolecule Purification

Bioinformatics and Omics

Signal

Protein Trafficking

Photosynthesis Nitrogen

Filters

Most Ran in the nucleus is bound to _, and most Ran in the cytosol is bound to _.

In eukaryotes, mRNAs are synthesized in the cell , whereas most translation occurs in The .

With differential splicing, humans can produce approximately _ as many proteins as their _ genes.