Question 1

A cDNA sequence is the ___________ region of a gene.

Accepted Answer

A)  regulatory 
B)  protein-coding 
C)  untranslated 
D)  epigenetic 
E)  none of the above 
A)  regulatory 
B)  protein-coding 
C)  untranslated 
D)  epigenetic 
E)  none of the above B

Question 2

ExPASy is a bioinformatics website that contains numerous tools. Among them is the Reverse Translate tool at
Http://www.bioinformatics.org/sms2/rev_trans.html. Go to this site, type in the peptide to find the cDNA sequence that encodes it:
  The answer is a ___ base sequence that starts with ______.

Accepted Answer

A)  30; ytngtngar 
B)  30; tcgatcgat 
C)  90; tttgtgaac 
D)  90; cgctgtatc 
E)  60; ctggtggaa 
A)  30; ytngtngar 
B)  30; tcgatcgat 
C)  90; tttgtgaac 
D)  90; cgctgtatc 
E)  60; ctggtggaa C

Question 3

When running cell-based experiments a large number of biochemical processes are taking place simultaneously and can continue after sample collection, confounding the results while additional samples are being harvested. To stabilize the composition of the reaction mixture researchers can ____.

Accepted Answer

A)  add a cocktail of inhibitors to the mixture 
B)  separate the mixture 
C)  evaporate the mixture 
D)  dilute the mixture 
E)  all of the above 
A)  add a cocktail of inhibitors to the mixture 
B)  separate the mixture 
C)  evaporate the mixture 
D)  dilute the mixture 
E)  all of the above A

Question 4

The _____ is an international nucleotide sequence repository maintained jointly by the U.S. National Center for Biotechnology Information (NCBI), the European Molecular Biology Laboratory (EMBL), and the DNA Data Bank of Japan (DDBJ).

Accepted Answer

A)  GenBank 
B)  PDB 
C)  Entrez Gene 
D)  PubMed 
E)  PubChem 
A)  GenBank 
B)  PDB 
C)  Entrez Gene 
D)  PubMed 
E)  PubChem

Question 5

BLAST is a(n) ___________ that uses FASTA format protein sequences or nucleic acid sequences.

Accepted Answer

A)  ionization assignment tool 
B)  molar mass tool 
C)  modeling tool 
D)  local alignment search tool 
E)  none of the above 
A)  ionization assignment tool 
B)  molar mass tool 
C)  modeling tool 
D)  local alignment search tool 
E)  none of the above

Question 6

Biological systems are always in flux. The ________ change the most on a short time scale.

Accepted Answer

A)  proteome and genome 
B)  genome and lipidome 
C)  metabolome and kinome 
D)  transcriptome and proteome 
E)  glycome and interactome 
A)  proteome and genome 
B)  genome and lipidome 
C)  metabolome and kinome 
D)  transcriptome and proteome 
E)  glycome and interactome

Question 7

The kinome is highly transient because it is a collection of ______ modifications of biomolecules made by kinases upon cell stimulation.

Accepted Answer

A)  esterification 
B)  hydrolysis 
C)  condensation 
D)  phosphorylation 
E)  none of the above 
A)  esterification 
B)  hydrolysis 
C)  condensation 
D)  phosphorylation 
E)  none of the above

Question 8

The National Institutes of Health (NIH) is responsible for biomedical and _________ research and it comprises ___ different institutes and centers.

Accepted Answer

The answer of The National Institutes of Health (NIH) is...

Question 9

The genome is consistent across an entire organism, because all the cells of an organism contain ____.

Accepted Answer

the same c

Question 10

The _____ is the collection of all the proteins in an organism, cell, or tissue. The half-lives of proteins vary depending on the cellular treatment during an experiment.

Accepted Answer

A)  metabolome 
B)  kinome 
C)  lipidome 
D)  proteome 
E)  interactome 
A)  metabolome 
B)  kinome 
C)  lipidome 
D)  proteome 
E)  interactome

Question 11

Use the NCBI site (
Https://www.ncbi.nlm.nih.gov/) and search for NP_001278826.1, without choosing a particular database. Click on the protein link. This protein ________.

Accepted Answer

A)  is of human origin 
B)  is 110 amino acids long 
C)  contains three protein segments: insulin B chain, C-peptide and insulin A chain 
D)  has a protein sequence that starts with a methionine 
E)  all of the above 
A)  is of human origin 
B)  is 110 amino acids long 
C)  contains three protein segments: insulin B chain, C-peptide and insulin A chain 
D)  has a protein sequence that starts with a methionine 
E)  all of the above

Question 12

Use the NCBI site (
Https://www.ncbi.nlm.nih.gov/) and search for NP_001278826.1, without choosing a particular database. The answer to your search contains access links to ___________.
I. labratory information
II. the protein sequence of insulin preproprotein
III. the Gene ID: 3630
IV. clinically significant information
V. references

Accepted Answer

A)  I and II 
B)  II and III 
C)  II, III and IV 
D)  II, III and V 
E)  none of the above 
A)  I and II 
B)  II and III 
C)  II, III and IV 
D)  II, III and V 
E)  none of the above

Question 13

________ is used to determine related sequences, to establish phylogenetic information, and to recognize tertiary motifs of proteins.

Accepted Answer

A)  Processing 
B)  Sequence alignment 
C)  Similarity search 
D)  Cross-referencing 
E)  none of the above 
A)  Processing 
B)  Sequence alignment 
C)  Similarity search 
D)  Cross-referencing 
E)  none of the above

Question 14

______ is related to the novel expression of the genes due to environmental factors without changes in the genetic code.

Accepted Answer

The answer of ______ is related to the novel expression...

Question 15

Use the NCBI site (
Https://www.ncbi.nlm.nih.gov/) and search for GI: 631226408, without choosing a particular database. The answer to your search is a ___________.

Accepted Answer

A)  nucleic acid sequence 
B)  protein 
C)  book 
D)  journal citation 
E)  all of the above 
A)  nucleic acid sequence 
B)  protein 
C)  book 
D)  journal citation 
E)  all of the above

Question 16

Protein sample preparation for mass spectrometry analysis, MALDI-TOF, includes (sometimes) ______.
I. protein labeling
II. protein sequencing
III. mixing with a matrix
IV. protein migration
V. protein separation

Accepted Answer

A)  I and II 
B)  II and III 
C)  I, III and V 
D)  III, IV and V 
E)  II, III and IV 
A)  I and II 
B)  II and III 
C)  I, III and V 
D)  III, IV and V 
E)  II, III and IV

Question 17

The most common programming languages used in developing bioinformatics tools are:
I. JavaScript
II. LabVIEW
III. R
IV. Python
V. BASIC-PLUS

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  I, III and IV 
E)  III and V 
A)  I 
B)  II 
C)  III 
D)  I, III and IV 
E)  III and V

Question 18

The National Center for Biotechnology Information (NCBI) site,
Https://www.ncbi.nlm.nih.gov/, can be searched by __________.

Accepted Answer

A)  GeneID 
B)  name of protein 
C)  accession number 
D)  GI number 
E)  all of the above 
A)  GeneID 
B)  name of protein 
C)  accession number 
D)  GI number 
E)  all of the above

Question 19

The National Institutes of Health (NIH) is the largest biomedical research center in the World. It is funded by the US government and its yearly budget is $41.7 billion (fiscal year 2020). This yearly budget is used for funding __________.

Accepted Answer

A)  intramural research 
B)  extramural research 
C)  RO1 grants 
D)  Early-Stage Investigator grants 
E)  all of the above 
A)  intramural research 
B)  extramural research 
C)  RO1 grants 
D)  Early-Stage Investigator grants 
E)  all of the above

Question 20

MALDI-TOF is used to characterize __________.

Accepted Answer

A)  food additives 
B)  proteins 
C)  pesticides 
D)  hydrocarbons 
E)  none of the above 
A)  food additives 
B)  proteins 
C)  pesticides 
D)  hydrocarbons 
E)  none of the above

Exam 22: Bioinformatics and Omics

A cDNA sequence is the ___________ region of a gene.

ExPASy is a bioinformatics website that contains numerous tools. Among them is the Reverse Translate tool at Http://www.bioinformatics.org/sms2/rev_trans.html. Go to this site, type in the peptide to find the cDNA sequence that encodes it: The answer is a ___ base sequence that starts with ______.

When running cell-based experiments a large number of biochemical processes are taking place simultaneously and can continue after sample collection, confounding the results while additional samples are being harvested. To stabilize the composition of the reaction mixture researchers can ____.

The _____ is an international nucleotide sequence repository maintained jointly by the U.S. National Center for Biotechnology Information (NCBI), the European Molecular Biology Laboratory (EMBL), and the DNA Data Bank of Japan (DDBJ).

BLAST is a(n) ___________ that uses FASTA format protein sequences or nucleic acid sequences.

Biological systems are always in flux. The ________ change the most on a short time scale.

The kinome is highly transient because it is a collection of ______ modifications of biomolecules made by kinases upon cell stimulation.

The National Institutes of Health (NIH) is responsible for biomedical and _________ research and it comprises ___ different institutes and centers.

The genome is consistent across an entire organism, because all the cells of an organism contain ____.

The _____ is the collection of all the proteins in an organism, cell, or tissue. The half-lives of proteins vary depending on the cellular treatment during an experiment.

Use the NCBI site ( Https://www.ncbi.nlm.nih.gov/) and search for NP_001278826.1, without choosing a particular database. Click on the protein link. This protein ________.

________ is used to determine related sequences, to establish phylogenetic information, and to recognize tertiary motifs of proteins.

______ is related to the novel expression of the genes due to environmental factors without changes in the genetic code.

Use the NCBI site ( Https://www.ncbi.nlm.nih.gov/) and search for GI: 631226408, without choosing a particular database. The answer to your search is a ___________.

Protein sample preparation for mass spectrometry analysis, MALDI-TOF, includes (sometimes) ______. I. protein labeling II. protein sequencing III. mixing with a matrix IV. protein migration V. protein separation

The most common programming languages used in developing bioinformatics tools are: I. JavaScript II. LabVIEW III. R IV. Python V. BASIC-PLUS

The National Center for Biotechnology Information (NCBI) site, Https://www.ncbi.nlm.nih.gov/, can be searched by __________.

The National Institutes of Health (NIH) is the largest biomedical research center in the World. It is funded by the US government and its yearly budget is $41.7 billion (fiscal year 2020). This yearly budget is used for funding __________.

MALDI-TOF is used to characterize __________.

The Chemical Foundations of Biochemistry

Nucleic Acids

Proteins I

Proteins Iienzymes

Membranes and an Introduction to Signal Transduction

Carbohydrates I

The Common Catabolic Pathway

Carbohydrates II

Lipids I

Lipids II

Amine Metabolism

Metabolism Integration

Nucleotide Deoxynucleotide Metabolism

Dna Replication, Damage and Repair

Rna Synthesis

Protein

Control of Gene

Determination of Macromolecular Structure

Allosterism and Receptor-Ligand

Designer Proteins and Protein Folding

Biomolecule Purification

Signal

Protein Trafficking

Photosynthesis Nitrogen

Filters

ExPASy is a bioinformatics website that contains numerous tools. Among them is the Reverse Translate tool at Http://www.bioinformatics.org/sms2/rev_trans.html. Go to this site, type in the peptide to find the cDNA sequence that encodes it: The answer is a _ base sequence that starts with ____.

The National Institutes of Health (NIH) is responsible for biomedical and _______ research and it comprises _ different institutes and centers.