Exam 13: Nucleotide Deoxynucleotide Metabolism

Which of the following are needed to regenerate the reduced form of ribonucleotide reductase? I. glutredoxin disulfide II. reduced glutathiones III. disulfide thioredoxin IV. FADH2

What coenzyme is used when inosine monophosphate is oxidized to xanthosine monophosphate?

The disease gout is characterized by high levels of _____, which forms crystal deposits of _____, resulting in painful joints

Which is NOT true of uric acid?

In the pyrimidine salvage pathway, cytidine is first deaminated to

The conversion of IMP to AMP requires _____; the conversion of IMP to GMP requires _____.

In Lesch-Nyhan syndrome, ___ is not salvaged, so is metabolized to uric acid, which accumulates in tissues.

Important to balancing deoxynucleotide concentrations is control of the enzyme ____.

The following is the structure for acyclovir, an antiviral drug: Similar to methotrexate and aminopterin, acyclovir is a(n) ______________, substituting for the deoxynucleotide ______________ during DNA synthesis.

What step is common to both purine and pyrimidine synthesis?

Which of the following amino acids is a source of both carbon and nitrogen for UMP?

____ is released as adenylosuccinate lyase catalyzes the conversion of adenylosuccinate to AMP.

The substrates of ribonucleotide reductase are

The energy for the conversion of IMP to GMP is supplied by _____.

Recombinant forms of the enzyme urate oxidase are available for therapeutic purposes. Based on the information in this chapter, the condition in which this therapy might be useful is _____

SCID devastating effects are due to ___ in immune cells, which must be ___ to be effective

Gout is treated using the compound ______.

Which of the following steps in purine biosynthesis are regulated by feedback inhibition by ADP and GDP? I. ribose-5-phosphate $\rightarrow$ PRPP II. PRPP $\rightarrow$ 5-phosphoribosame III. glycine ribonucleotide $\rightarrow$ formylglycinamide ribonucleotide IV. FAICAR $\rightarrow$ IMP V. IMP $\rightarrow$ adenylosuccinate

During the turnover of nucleic acids some purines can be reincorporated into nucleotides via _____ pathways.

Which of the following organisms excrete uric acid?