Question 1

Aplastic anemia is most often caused by:

Accepted Answer

A) Drugs 
B) Radiation 
C) Unknown causes 
D) Infectious agents 
A) Drugs 
B) Radiation 
C) Unknown causes 
D) Infectious agents

Question 2

Which of the following tests would help differentiate TEC from DBA?

Accepted Answer

A) RBC count and RBC indices 
B) Bone marrow cellularity and M:E ratio 
C) Fetal erythrocyte characteristics 
D) Ham test 
A) RBC count and RBC indices 
B) Bone marrow cellularity and M:E ratio 
C) Fetal erythrocyte characteristics 
D) Ham test

Question 3

The cytopenias associated with MDS are caused by:

Accepted Answer

A) Dyshematopoiesis 
B) Bone marrow replacement 
C) Hypoplasia of the bone marrow 
D) Decreased cytokine production 
A) Dyshematopoiesis 
B) Bone marrow replacement 
C) Hypoplasia of the bone marrow 
D) Decreased cytokine production

Question 4

A 55-year-old male is undergoing dialysis to treat his renal failure.Routine blood examination shows a low RBC count,low H&H,and a normal MCV.What is the most important factor contributing to this anemia?

Accepted Answer

A) Ineffective erythropoiesis 
B) Hemolysis 
C) Decreased erythropoietin production 
D) Presence of cytotoxic antibodies to erythropoietin-sensitive cells 
A) Ineffective erythropoiesis 
B) Hemolysis 
C) Decreased erythropoietin production 
D) Presence of cytotoxic antibodies to erythropoietin-sensitive cells

Question 5

What CBC parameter would help differentiate Fanconi's syndrome from Diamond-Blackfan anemia?

Accepted Answer

A) MCV 
B) WBC and PLT counts 
C) RBC counts 
D) Differential 
A) MCV 
B) WBC and PLT counts 
C) RBC counts 
D) Differential

Question 6

Which of the following contributes to the production of hypocellular bone marrow?

Accepted Answer

A) Damage to the stem or progenitor cells in the bone marrow 
B) Iron storage disease 
C) Gene mutations 
D) Hemoglobinopathy 
A) Damage to the stem or progenitor cells in the bone marrow 
B) Iron storage disease 
C) Gene mutations 
D) Hemoglobinopathy

Question 7

How can infection with the Epstein-Barr virus (EBV)lead to aplastic anemia?

Accepted Answer

A) EBV causes defects in precursor cells. 
B) EBV infects stem cells,and an immune response to destroy the stem cells is initiated. 
C) EBV creates immune complexes on the surface of the stem cell that damages it. 
D) Infection with the virus shuts down cytokine production by macrophages. 
A) EBV causes defects in precursor cells. 
B) EBV infects stem cells,and an immune response to destroy the stem cells is initiated. 
C) EBV creates immune complexes on the surface of the stem cell that damages it. 
D) Infection with the virus shuts down cytokine production by macrophages.

Question 8

Acquired chronic pure red cell aplasia is a rare disorder encountered in association with several autoimmune disorders.What does the mechanism appear to be?

Accepted Answer

A) B cell-mediated immunosuppression of neutrophils 
B) T cell-mediated immunosuppression of erythropoiesis 
C) Cytokine-mediated immunosuppression of erythropoiesis 
D) Increased serum erythropoietin 
A) B cell-mediated immunosuppression of neutrophils 
B) T cell-mediated immunosuppression of erythropoiesis 
C) Cytokine-mediated immunosuppression of erythropoiesis 
D) Increased serum erythropoietin

Question 9

Chronic renal disease is a common cause of anemia.Which of the following is one of the possible causes of anemia in chronic renal disease?

Accepted Answer

A) Increased erythropoietin production 
B) Increased erythrocyte survival 
C) Blood loss 
D) Iron production 
A) Increased erythropoietin production 
B) Increased erythrocyte survival 
C) Blood loss 
D) Iron production

Question 10

Patients with renal disease are at risk for developing megaloblastic anemia because of:

Accepted Answer

A) Decreased EPO production and utilization 
B) Increased NADPH production 
C) Folate deficiency 
D) Acute blood loss 
A) Decreased EPO production and utilization 
B) Increased NADPH production 
C) Folate deficiency 
D) Acute blood loss

Question 11

What congenital defects are found in Fanconi's syndrome?

Accepted Answer

A) Hypergonadism 
B) Skin hypopigmentation 
C) Mental retardation 
D) Thrombocytic purpura 
A) Hypergonadism 
B) Skin hypopigmentation 
C) Mental retardation 
D) Thrombocytic purpura

Question 12

A 5-year-old boy with malformed thumbs and microcephaly has been suffering from prolonged bleeding episodes,extreme fatigue,and persistent repetitive infections.Cytogenetic analysis shows increased chromosome breakage with the addition of diepoxybutane.Based on these findings,what is the patient most likely suffering from?

Accepted Answer

A) CDA II 
B) Pure red cell aplasia 
C) Diamond-Blackfan anemia 
D) Fanconi's syndrome 
A) CDA II 
B) Pure red cell aplasia 
C) Diamond-Blackfan anemia 
D) Fanconi's syndrome

Exam 16: Hypoproliferative Anemias

Aplastic anemia is most often caused by:

Which of the following tests would help differentiate TEC from DBA?

The cytopenias associated with MDS are caused by:

A 55-year-old male is undergoing dialysis to treat his renal failure.Routine blood examination shows a low RBC count,low H&H,and a normal MCV.What is the most important factor contributing to this anemia?

What CBC parameter would help differentiate Fanconi's syndrome from Diamond-Blackfan anemia?

Which of the following contributes to the production of hypocellular bone marrow?

How can infection with the Epstein-Barr virus (EBV)lead to aplastic anemia?

Acquired chronic pure red cell aplasia is a rare disorder encountered in association with several autoimmune disorders.What does the mechanism appear to be?

Chronic renal disease is a common cause of anemia.Which of the following is one of the possible causes of anemia in chronic renal disease?

Patients with renal disease are at risk for developing megaloblastic anemia because of:

What congenital defects are found in Fanconi's syndrome?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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