Exam 27: Precursor Lymphoid Neoplasms

The WHO classification of subgroups of ALL uses which of these criteria to help define the categories?

Name the classifications of ALL,and explain how they differ in molecular analysis and immunophenotype.

A laboratory professional notices many immature blasts exhibiting prominent cytoplasmic basophilia and vacuolization on a peripheral blood smear.Cytogenetic analysis performed on the patient identified a translocation between chromosomes 8 and 14.Based on this information,from what is the patient most likely suffering?

Contrast the clinical and laboratory findings of ALL to LBL.

Which leukemia reveals the laboratory findings of TdT+,CD7+,and CD3+?

The most common form of ALL relapse in children is:

Which phase of leukemia treatment is considered to induce complete remission of the disease,eradicating the leukemic blast population?

A patient,2 years of age,presents with general fatigue,pallor,fever,and weight loss.The morphological exam reveals a normal leukocyte count,marked neutropenia,and thrombocytopenia with 35% blasts.A bone marrow smear reveals hypercellularity with neoplastic lymphoid cells.What immunophenotypic testing would be indicated for this patient?

B-cell ALL/LBL with recurrent genetic abnormalities includes all of the following translocations except:

A patient with ALL underwent chemotherapy.Results from hematologic,cytogenetic,and molecular analyses indicated that the patient entered complete remission.Four years later,on routine follow-up,the peripheral blood results for the patient were in the normal range,and cytogenetic analysis revealed no abnormalities,but molecular analysis showed BCR/ABL1 transcripts that were found in the blasts at diagnosis 4 years ago.This patient can be said to:

Which of the following is an expected finding in the peripheral blood smear of an ALL patient?

A phenotype workup is performed on a patient suspected to have ALL.The results indicate that some of the leukemic cells express myeloid markers ,whereas others express T-cell markers.What is the most likely reason for this occurrence?

Questions 8-10: Use this case to answer the following questions: A 6-year-old boy was taken to see his pediatrician because of tiny pinpoint spots that had appeared on his upper torso 3 days earlier.A CBC revealed 70% blasts,and a platelet count of 18 × 10⁹/L.A bone marrow aspirate and biopsy indicate a diagnosis of ALL. -Which of the following sets of markers would be useful for follow-up testing to differentiate B-cell ALL from T-cell ALL?

What cytochemical stains are negative in ALL but positive in AML?