Question 1

Give at least five markers of differentiation between acute and chronic ITP.

Accepted Answer

a.	Age of the patient >>> acute: typical

Question 2

A patient is known to be a chronic alcoholic.His blood is drawn,and his platelet count is 72 x 10⁹/L.What is the most likely reason for this occurrence?

Accepted Answer

A) Immune-mediated thrombocytopenia 
B) Acquired hypoplasia resulting from alcohol consumption 
C) Dilutional thrombocytopenia from liver dysfunction 
D) Increased destruction of platelets 
A) Immune-mediated thrombocytopenia 
B) Acquired hypoplasia resulting from alcohol consumption 
C) Dilutional thrombocytopenia from liver dysfunction 
D) Increased destruction of platelets

Question 3

What is the most common cause of thrombocytopenia?

Accepted Answer

A) Increased consumption 
B) Increased destruction 
C) Decreased production 
D) Increased splenic sequestration 
A) Increased consumption 
B) Increased destruction 
C) Decreased production 
D) Increased splenic sequestration

Question 4

Scurvy can lead to vascular defects by which of the following mechanisms?

Accepted Answer

A) Degeneration of ECM 
B) Excessive breakdown of collagen 
C) Insufficient collagen synthesis 
D) Presence of paraproteins directed against collagen 
A) Degeneration of ECM 
B) Excessive breakdown of collagen 
C) Insufficient collagen synthesis 
D) Presence of paraproteins directed against collagen

Question 5

Acquired disorders of the vascular system including senile purpura,Cushing's syndrome,corticosteroid therapy,and scurvy have one condition in common.Which of the following best describes this condition?

Accepted Answer

A) Decreased amount of supportive connective tissue in the blood vessel walls 
B) Presence of abnormal proteins in the vascular system 
C) Inflammation of the small blood vessels 
D) Increased pressure within the lumen of capillaries after intense exercise 
A) Decreased amount of supportive connective tissue in the blood vessel walls 
B) Presence of abnormal proteins in the vascular system 
C) Inflammation of the small blood vessels 
D) Increased pressure within the lumen of capillaries after intense exercise

Question 6

Which of the following best describes the effect of aspirin on platelets,and for how long does the effect last?

Accepted Answer

A) ADP receptor blockade;5 days 
B) Thrombocytosis;7 days 
C) Inactivation of cyclooxygenase;7 days 
D) Thrombocytopenia;7 days 
A) ADP receptor blockade;5 days 
B) Thrombocytosis;7 days 
C) Inactivation of cyclooxygenase;7 days 
D) Thrombocytopenia;7 days

Question 7

Minimum screening test(s)that should be considered in the evaluation of abnormal bleeding is(are)which of the following?

Accepted Answer

A) Thrombin time 
B) Fibrinogen level 
C) Factor studies 
D) Platelet count,PT,APTT 
A) Thrombin time 
B) Fibrinogen level 
C) Factor studies 
D) Platelet count,PT,APTT

Question 8

Thrombocytosis is associated with which of the following?

Accepted Answer

A) Acute leukemia 
B) ITP 
C) HUS 
D) Myeloproliferative disorder 
A) Acute leukemia 
B) ITP 
C) HUS 
D) Myeloproliferative disorder

Question 9

Explain the pathophysiology of the following and why each typically has normal coagulation screening tests.
a.Bernard-Soulier syndrome
b.Glanzmann's thrombasthenia
c.-storage pool disease
d.Gray platelet syndrome

Accepted Answer

Answer regarding pathophysiology:Bernard

Question 10

All of the following are conditions associated with reactive thrombocytosis except:

Accepted Answer

A) Acute hemorrhage 
B) Postsplenectomy 
C) Chronic idiopathic myelofibrosis 
D) Iron deficiency anemia 
A) Acute hemorrhage 
B) Postsplenectomy 
C) Chronic idiopathic myelofibrosis 
D) Iron deficiency anemia

Question 11

A 35-year-old female is hospitalized for knee replacement surgery.Preoperative blood tests reveal a platelet count of 64 x 10⁹/L.The surgery is postponed,and the platelet count is repeated two days later when it is 48 x 10⁹/L.All other labs appear normal.Based on this information,from what is the patient most likely suffering?

Accepted Answer

A) Acute ITP 
B) Chronic ITP 
C) TTP 
D) HUS 
A) Acute ITP 
B) Chronic ITP 
C) TTP 
D) HUS

Question 12

Splenomegaly can cause thrombocytopenia by which of the following mechanisms?

Accepted Answer

A) Impaired production 
B) Platelet sequestration 
C) Immune-mediated 
D) Mechanical destruction 
A) Impaired production 
B) Platelet sequestration 
C) Immune-mediated 
D) Mechanical destruction

Question 13

A patient is exhibiting multiple pinpoint hemorrhages on his upper torso.This would be described as:

Accepted Answer

A) Hematomas 
B) Ecchymoses 
C) Purpura 
D) Petechiae 
A) Hematomas 
B) Ecchymoses 
C) Purpura 
D) Petechiae

Question 14

Which of the following is not a mechanism of inducing thrombocytopenia in a patient?

Accepted Answer

A) Antibody-mediated platelet destruction 
B) Inherited platelet membrane defect 
C) Increased splenic sequestration 
D) Inherited defect in release of ADP and ATP 
A) Antibody-mediated platelet destruction 
B) Inherited platelet membrane defect 
C) Increased splenic sequestration 
D) Inherited defect in release of ADP and ATP

Question 15

Immune complexes induce vasculitis by which of the following processes?

Accepted Answer

A) Inducing aggregation of platelets and activation factor XII 
B) Increasing pressure within the lumen of capillaries 
C) Forming thrombi in the small vessels,inducing necrosis 
D) Releasing enzymes and free oxygen radicals from neutrophils that have migrated to the area to phagocytize the immune complexes 
A) Inducing aggregation of platelets and activation factor XII 
B) Increasing pressure within the lumen of capillaries 
C) Forming thrombi in the small vessels,inducing necrosis 
D) Releasing enzymes and free oxygen radicals from neutrophils that have migrated to the area to phagocytize the immune complexes

Exam 33: Disorders of Primary Hemostasis

Give at least five markers of differentiation between acute and chronic ITP.

A patient is known to be a chronic alcoholic.His blood is drawn,and his platelet count is 72 x 10⁹/L.What is the most likely reason for this occurrence?

What is the most common cause of thrombocytopenia?

Scurvy can lead to vascular defects by which of the following mechanisms?

Acquired disorders of the vascular system including senile purpura,Cushing's syndrome,corticosteroid therapy,and scurvy have one condition in common.Which of the following best describes this condition?

Which of the following best describes the effect of aspirin on platelets,and for how long does the effect last?

Minimum screening test(s)that should be considered in the evaluation of abnormal bleeding is(are)which of the following?

Thrombocytosis is associated with which of the following?

Explain the pathophysiology of the following and why each typically has normal coagulation screening tests. a.Bernard-Soulier syndrome b.Glanzmann's thrombasthenia c.-storage pool disease d.Gray platelet syndrome

All of the following are conditions associated with reactive thrombocytosis except:

Splenomegaly can cause thrombocytopenia by which of the following mechanisms?

A patient is exhibiting multiple pinpoint hemorrhages on his upper torso.This would be described as:

Which of the following is not a mechanism of inducing thrombocytopenia in a patient?

Immune complexes induce vasculitis by which of the following processes?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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