Question 1

Which of the following is targeted by the SCF complex?

Accepted Answer

A) Cdh1 
B) cyclin B 
C) securin 
D) Sic1 
A) Cdh1 
B) cyclin B 
C) securin 
D) Sic1

Question 2

Cyclin D/Cdk4 functions during:

Accepted Answer

A) G₁. 
B) S. 
C) G₂. 
D) M. 
A) G₁. 
B) S. 
C) G₂. 
D) M.

Question 3

The S.cerevisiae homolog of Xenopus MPF is:

Accepted Answer

A) Cdc13-Cdc2. 
B) Cdc25-Cdc2. 
C) Clb1-Cdc28. 
D) Cln3-Cdc28. 
A) Cdc13-Cdc2. 
B) Cdc25-Cdc2. 
C) Clb1-Cdc28. 
D) Cln3-Cdc28.

Question 4

How do chromosome movements differ between meiosis I and meiosis II? Is spindle composition the basis for this distinction?

Accepted Answer

During meiosis I,synapsed homologous chr

Question 5

Exit from mitosis depends upon the degradation of:

Accepted Answer

A) cohesion. 
B) condensin. 
C) cyclin B. 
D) securin. 
A) cohesion. 
B) condensin. 
C) cyclin B. 
D) securin.

Question 6

DNA replication at each origin occurs only once during the cell cycle because of:

Accepted Answer

A) specificity of the origin-recognition complex (OR
C) . 
B) S phase Cdk phosphorylating MCM helicase. 
C) MCM helicase loading by M phase cyclins. 
D) G1 cyclin/cdk activation of E2F. 
A) specificity of the origin-recognition complex (OR
C) . 
B) S phase Cdk phosphorylating MCM helicase. 
C) MCM helicase loading by M phase cyclins. 
D) G1 cyclin/cdk activation of E2F.

Question 7

What is a cdc mutant? What protein is encoded by cdc2 in fission yeast?

Accepted Answer

The abbreviation "cdc" stands for "cell-

Question 8

Centromeric Rec8 becomes cleaved during:

Accepted Answer

A) meiosis I. 
B) meiosis II. 
C) mitosis. 
D) none of the above 
A) meiosis I. 
B) meiosis II. 
C) mitosis. 
D) none of the above

Question 9

Mitotic cyclin levels in early Xenopus embryos are regulated by:

Accepted Answer

A) phosphorylation. 
B) synthesis and degradation of their mRNAs. 
C) degradation by APC. 
D) degradation by MPF. 
A) phosphorylation. 
B) synthesis and degradation of their mRNAs. 
C) degradation by APC. 
D) degradation by MPF.

Question 10

How does p53 function as a tumor-suppressor protein?

Accepted Answer

When p53 becomes stabilized in response

Question 11

After addition of serum to G₀-arrested mammalian cells,two classes of genes are expressed: early-response genes and delayed-response genes.Explain why expression of delayed-response genes is blocked by inhibitors of protein synthesis but expression of early-response genes is not.

Accepted Answer

Transcription of early-response genes af

Question 12

During mitosis,the breakdown of the nuclear envelope depends on the:

Accepted Answer

A) disassembly following proteasomal degradation of intermediate filaments. 
B) disassembly of lamin filaments following phosphorylation by mitotic cyclin/cdk complexes. 
C) ubiquitination of mitotic cyclin proteins. 
D) lamin filament dephosphorylation by cdc14. 
A) disassembly following proteasomal degradation of intermediate filaments. 
B) disassembly of lamin filaments following phosphorylation by mitotic cyclin/cdk complexes. 
C) ubiquitination of mitotic cyclin proteins. 
D) lamin filament dephosphorylation by cdc14.

Question 13

Which of the following inhibit(s)cyclin A/Cdk2 activity?

Accepted Answer

A) INK4 
B) p21ᶜᴵᴾ 
C) Rb 
D) INK4 and Rb 
A) INK4 
B) p21ᶜᴵᴾ 
C) Rb 
D) INK4 and Rb

Question 14

Injection of an immature Xenopus oocyte with MPF induces:

Accepted Answer

A) meiosis. 
B) oocyte maturation. 
C) synthesis of progesterone. 
D) meiosis and oocyte maturation. 
A) meiosis. 
B) oocyte maturation. 
C) synthesis of progesterone. 
D) meiosis and oocyte maturation.

Question 15

How does the presence of unreplicated DNA prevent entry into mitosis?

Accepted Answer

Inter-S phase checkpoint control involve

Question 16

Which of the following S.pombe mutants is(are)larger than normal?

Accepted Answer

A) cdc2ᴰ 
B) cdc25− 
C) wee1− 
D) cdc25− and wee1− 
A) cdc2ᴰ 
B) cdc25− 
C) wee1− 
D) cdc25− and wee1−

Question 17

Compare cohesin function during mitosis and meiosis.

Accepted Answer

During mitosis,sister chromatids are ini

Question 18

What is START? How does nutritional status determine whether S.cerevisiae cells will pass START?

Accepted Answer

START defines the point in the cell cycl

Question 19

What is the difference between a kinetochore and a centromere?

Accepted Answer

The kinetochore is a multiprotein comple

Question 20

Separation of spindle poles during spindle formation and anaphase B most likely depends on which of the following?

Accepted Answer

A) (+)end-directed microtubule motors at the cell cortex 
B) (+)end-directed microtubule motors at the kinetochore 
C) (−)end-directed microtubule motors in the microtubule overlap zone 
D) (+)end-directed microtubule motors in the microtubule overlap zone 
A) (+)end-directed microtubule motors at the cell cortex 
B) (+)end-directed microtubule motors at the kinetochore 
C) (−)end-directed microtubule motors in the microtubule overlap zone 
D) (+)end-directed microtubule motors in the microtubule overlap zone

Exam 18: Regulating the Eukaryotic Cell Cycle

Which of the following is targeted by the SCF complex?

Cyclin D/Cdk4 functions during:

The S.cerevisiae homolog of Xenopus MPF is:

How do chromosome movements differ between meiosis I and meiosis II? Is spindle composition the basis for this distinction?

Exit from mitosis depends upon the degradation of:

DNA replication at each origin occurs only once during the cell cycle because of:

What is a cdc mutant? What protein is encoded by cdc2 in fission yeast?

Centromeric Rec8 becomes cleaved during:

Mitotic cyclin levels in early Xenopus embryos are regulated by:

How does p53 function as a tumor-suppressor protein?

After addition of serum to G₀-arrested mammalian cells,two classes of genes are expressed: early-response genes and delayed-response genes.Explain why expression of delayed-response genes is blocked by inhibitors of protein synthesis but expression of early-response genes is not.

During mitosis,the breakdown of the nuclear envelope depends on the:

Which of the following inhibit(s)cyclin A/Cdk2 activity?

Injection of an immature Xenopus oocyte with MPF induces:

How does the presence of unreplicated DNA prevent entry into mitosis?

Which of the following S.pombe mutants is(are)larger than normal?

Compare cohesin function during mitosis and meiosis.

What is START? How does nutritional status determine whether S.cerevisiae cells will pass START?

What is the difference between a kinetochore and a centromere?

Separation of spindle poles during spindle formation and anaphase B most likely depends on which of the following?

Chemical Foundations

Molecular Genetic Techniques

Protein Structure and Function

Culturing and Visualizing Cells

Fundamental Molecular Genetic Mechanisms

Bio-membrane Structure

Genes Genomics and Chromosomes

Transcriptional Control of Gene Expression

Post-Transcriptional Gene Control

Transmembrane Transport of Ions and Small Molecules

Cellular Energetics

Moving Proteins Into Membranes and Organelles

Vesicular Traffic, Secretion, and Endocytosis

Signal Transduction and G-Protein Coupled Receptors

Signaling Pathways That Control Gene Activity

Cell Organization and Movement I: Microfilaments

Cell Organization and Movement II: Microtubules and Intermediate Filaments

Integrating Cells Into Tissues

Cell Birth, Lineage, and Death

Nerve Cells

Immunology

Cancer

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