Question 1

A gene that has been introduced into a cell or an organism is known as a:

Accepted Answer

A)  Polygene 
B)  Cisgene 
C)  Transgene 
D)  Xenogene 
E)  Autogene 
A)  Polygene 
B)  Cisgene 
C)  Transgene 
D)  Xenogene 
E)  Autogene C

Question 2

The genetic cause of Huntington's disease can best be described as a/an:

Accepted Answer

A)  Increased trinucleotide repeat in the huntingtin gene 
B)  Increased trinuclotide repeat in the fibrosin gene 
C)  Decreased trinucleotide repeat in the huntingtin gene 
D)  Decreased trinucleotide repeat in the fibrosin gene 
E)  None of these 
A)  Increased trinucleotide repeat in the huntingtin gene 
B)  Increased trinuclotide repeat in the fibrosin gene 
C)  Decreased trinucleotide repeat in the huntingtin gene 
D)  Decreased trinucleotide repeat in the fibrosin gene 
E)  None of these A

Question 3

Why was the use of the sweat gland cDNA library critical in identifying the CF gene?
1)The CF gene is only expressed in epithelial cells of the lungs,pancreas,salivary glands,sweat glands,intestine,and reproductive tract
2)The CF gene is not expressed in any other tissue than sweat glands
3)The CF gene is not expressed in sweat glands

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these 
A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these A

Question 4

What is the molecular basis for Huntington's Disease? Describe a simple molecular technique that is often used to test for this defect.

Accepted Answer

Huntington's disease is associated with

Question 5

Why is it necessary to examine DNA from a child's mother in order to determine paternity?
1)Approximately half of the bands in the child's DNA print result from maternal DNA sequences,therefore it is necessary to account for the presence of these bands when comparing the DNA to the potential fathers
2)Approximately half of the bands in the child's DNA print result from maternal DNA sequences,and it is in the child's best interest to confirm maternity as well as paternity.
3)Approximately half of the bands in the child's DNA print result from maternal DNA sequences,and it is cheaper to determine maternity than it is paternity.

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these 
A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these

Question 6

How does the CF gene product cause clinical manifestations of the disease Cystic Fibrosis?

Accepted Answer

The CF gene product,called the cystic fi

Question 7

Which of the following is a possible use for DNA fingerprinting?
1)Identifying the father of a child
2)Identifying the presence of a person at a scene of a crime
3)Identifying an unknown soldier

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these 
A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these

Question 8

Currently white blood cells have been used in the somatic cell gene therapy treatment for patients with ADA-SCID,but their short lifespan is prohibitive in the treatment plan.What other type of cell could be used,and is being tested,with better results?

Accepted Answer

A)  Bone marrow stem cells 
B)  Red blood cells 
C)  Epithelial cells 
D)  T lymphocytes 
E)  B lymphocytes 
A)  Bone marrow stem cells 
B)  Red blood cells 
C)  Epithelial cells 
D)  T lymphocytes 
E)  B lymphocytes

Question 9

How can the DNA test for Huntington's disease potentially diminish human suffering because of this disease?

Accepted Answer

While the test for the HD mutation has n

Question 10

When was DNA fingerprinting first used as a forensic application in a court of law?

Accepted Answer

A)  1987 
B)  1988 
C)  1989 
D)  1990 
E)  1991 
A)  1987 
B)  1988 
C)  1989 
D)  1990 
E)  1991

Question 11

How many CAG nucleotide repeats are commonly found in patients with Huntington's disease?

Accepted Answer

A)  1-10 
B)  11-34 
C)  42-100 
D)  200-500 
E)  1000-2000 
A)  1-10 
B)  11-34 
C)  42-100 
D)  200-500 
E)  1000-2000

Question 12

The first use of gene therapy occurred in 1990 on a patient with which of the following diseases?

Accepted Answer

A)  Huntington's disease 
B)  Cystic fibrosis 
C)  ADA-SCID 
D)  AIDS 
E)  Systemic lupus 
A)  Huntington's disease 
B)  Cystic fibrosis 
C)  ADA-SCID 
D)  AIDS 
E)  Systemic lupus

Question 13

Which of the following was the second pharmaceutical protein produced by bacteria approved for human use?

Accepted Answer

A)  Insulin 
B)  hGH 
C)  Erythropoietin 
D)  Rennin 
E)  Interferon 
A)  Insulin 
B)  hGH 
C)  Erythropoietin 
D)  Rennin 
E)  Interferon

Question 14

The characterization of the huntingtin and CF genes has led to which of the following?

Accepted Answer

A)  DNA tests for the mutations which cause the respective diseases 
B)  DNA tests for the protein that is formed in the respective diseases 
C)  Treatments for the respective diseases 
D)  Treatments for all neurological degenerative diseases 
E)  None of these 
A)  DNA tests for the mutations which cause the respective diseases 
B)  DNA tests for the protein that is formed in the respective diseases 
C)  Treatments for the respective diseases 
D)  Treatments for all neurological degenerative diseases 
E)  None of these

Question 15

Totipotency refers to:

Accepted Answer

A)  The ability of a mammalian cell to develop into a differentiated cell. 
B)  The ability of a plant cell to accept foreign DNA. 
C)  The ability of a bacterial cell to express foreign DNA. 
D)  The ability of a plant or animal cell to produce all of the differentiated cells of the mature plant. 
E)  The ability of a mammalian cell to express all of the genes encoded by the genome. 
A)  The ability of a mammalian cell to develop into a differentiated cell. 
B)  The ability of a plant cell to accept foreign DNA. 
C)  The ability of a bacterial cell to express foreign DNA. 
D)  The ability of a plant or animal cell to produce all of the differentiated cells of the mature plant. 
E)  The ability of a mammalian cell to express all of the genes encoded by the genome.

Question 16

Which of the following types of fragments are commonly used to create DNA fingerprints?

Accepted Answer

A)  VNTRs 
B)  STRs 
C)  ESTs 
D)  VNTRs and STRs 
E)  All of these 
A)  VNTRs 
B)  STRs 
C)  ESTs 
D)  VNTRs and STRs 
E)  All of these

Question 17

The mutation that causes sickle cell anemia can be tested for by:
1)Testing for the presence or absence of a specific restriction enzyme cleavage site in DNA
2)Testing for the presence of a trinucleotide repeat in DNA
3)Testing for the absence of a trinucleotide repeat in DNA

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these 
A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these

Question 18

When testing for the presence of the sickle cell anemia Hbb allele,a Southern blot exhibits two small bands for the Hbb? allele and one band for the Hbb allele.What do these results mean?

Accepted Answer

A)  The subject is homozygous for the sickle cell allele 
B)  The subject is heterozygous 
C)  The subject is homozygous for the normal allele 
D)  The results are inconclusive and the test will need to be run again 
E)  Southern blots cannot test for the presence of the sickle cell allele 
A)  The subject is homozygous for the sickle cell allele 
B)  The subject is heterozygous 
C)  The subject is homozygous for the normal allele 
D)  The results are inconclusive and the test will need to be run again 
E)  Southern blots cannot test for the presence of the sickle cell allele

Question 19

Which of the following techniques is used to test for unstable trinucleotide repeats associated with Huntington's disease?

Accepted Answer

A)  Positional cloning 
B)  DNA sequencing 
C)  PCR 
D)  In situ hybridization 
E)  Northern blotting 
A)  Positional cloning 
B)  DNA sequencing 
C)  PCR 
D)  In situ hybridization 
E)  Northern blotting

Question 20

Somatic cell gene therapy requires a retroviral vector used.As a result,use of the therapy to treat _____ has led to leukemia.

Accepted Answer

A)  Huntington's disease 
B)  Cystic Fibrosis 
C)  X-linked SCID 
D)  ADA-SCID 
E)  ALS 
A)  Huntington's disease 
B)  Cystic Fibrosis 
C)  X-linked SCID 
D)  ADA-SCID 
E)  ALS

Exam 16: Applications Of Molecular Genetics

A gene that has been introduced into a cell or an organism is known as a:

The genetic cause of Huntington's disease can best be described as a/an:

What is the molecular basis for Huntington's Disease? Describe a simple molecular technique that is often used to test for this defect.

How does the CF gene product cause clinical manifestations of the disease Cystic Fibrosis?

Which of the following is a possible use for DNA fingerprinting? 1)Identifying the father of a child 2)Identifying the presence of a person at a scene of a crime 3)Identifying an unknown soldier

Currently white blood cells have been used in the somatic cell gene therapy treatment for patients with ADA-SCID,but their short lifespan is prohibitive in the treatment plan.What other type of cell could be used,and is being tested,with better results?

How can the DNA test for Huntington's disease potentially diminish human suffering because of this disease?

When was DNA fingerprinting first used as a forensic application in a court of law?

How many CAG nucleotide repeats are commonly found in patients with Huntington's disease?

The first use of gene therapy occurred in 1990 on a patient with which of the following diseases?

Which of the following was the second pharmaceutical protein produced by bacteria approved for human use?

The characterization of the huntingtin and CF genes has led to which of the following?

Totipotency refers to:

Which of the following types of fragments are commonly used to create DNA fingerprints?

The mutation that causes sickle cell anemia can be tested for by: 1)Testing for the presence or absence of a specific restriction enzyme cleavage site in DNA 2)Testing for the presence of a trinucleotide repeat in DNA 3)Testing for the absence of a trinucleotide repeat in DNA

When testing for the presence of the sickle cell anemia Hbb allele,a Southern blot exhibits two small bands for the Hbb? allele and one band for the Hbb allele.What do these results mean?

Which of the following techniques is used to test for unstable trinucleotide repeats associated with Huntington's disease?

Somatic cell gene therapy requires a retroviral vector used.As a result,use of the therapy to treat _____ has led to leukemia.

The Science Of Genetics

Cellular Reproduction

Mendelism The Basic Principles Of Inheritance

Extensions Of Mendelism

The Chromosomal Basis Of Mendelism

Variation In Chromosome Number And Structure

Linkage,Crossing Over,And Chromosome Mapping In …

The Genetics Of Bacteria And Their Viruses

DNA And The Molecular Structure Of Chromosomes

Replication Of DNA And Chromosomes

Transcription And RNA Processing

Translation And The Genetic Code

Mutation,DNA Repair,And Recombination

The Techniques Of Molecular Genetics

Genomics

Transposable Genetics Elements

Regulation Of Gene Expression In Prokaryotes

Regulation Of Gene Expression In Eukaryotes

The Genetic Control Of Animal Development

The Genetic Basis Of Cancer

Inheritance Of Complex Traits

Population Genetics

Evolutionary Genetics

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